Antithrombotic medical materials and medical apparatus using the same materials
A medical material that is excellent in antithrombogenicity even under a severe use condition in which thrombi are easily formed, is provided. The medical material contains a water-insoluble copolymer including a repeating unit (A) (which is derived from acryloylmorpholine, for example) and a repeating unit (B) (which is derived from methoxyethyl acrylate, for example), in which the water-insoluble copolymer has 5 mole % to 20 mole % of the repeating unit (A) with respect to all constituent units of the copolymer.
1. A medical apparatus comprising:
a base material having a stepped surface; and
a coating layer containing a medical material on the surface of the base material, the medical material comprising:
a water-insoluble copolymer comprising:
a repeating unit (A) represented by the following Formula (1):
wherein in Formula (1), R 11 is a hydrogen atom or a methyl group and X is represented by the following Formula (1a):
wherein in Formula (1a), R 12 and R 13 are ethylene groups and Y is an oxygen atom; and
a repeating unit (B) represented by the following Formula (2):
wherein in Formula (2), R 21 is a hydrogen atom or a methyl group, R 22 is an alkylene group having 1 to 4 carbon atoms, and R 23 is an alkyl group having 1 to 4 carbon atoms,
wherein the water-insoluble copolymer has 6 mole % to 19 mole % of the repeating unit (A) with respect to all constituent units of the copolymer.
2. The medical apparatus according to claim 1 , wherein the copolymer has 81 mole % to 94 mole % of the repeating unit (B) with respect to all constituent units of the copolymer.
3. The medical apparatus according to claim 1 , wherein the total amount of the repeating unit (A) and the repeating unit (B) is 100 mole % with respect to all constituent units of the copolymer.
4. The medical apparatus according to claim 1 , wherein in Formula (1), R 11 is hydrogen.
5. The medical material apparatus according to claim 1 , wherein in Formula (2), R 21 is hydrogen.
6. The medical apparatus according to claim 1 , wherein in Formula (2), R 22 is a straight or branched-chain alkylene group having 1 to 3 carbon atoms.
7. The medical apparatus according to claim 1 , wherein in Formula (2), R 23 is a straight or branched-chain alkyl group having 1 to 3 carbon atoms.
8. The medical apparatus according to claim 1 , wherein the copolymer further comprises a third repeating unit in an amount of less than or equal to 15 mole % with respect to all constituent units of the copolymer.
9. The medical apparatus according to claim 2 , wherein in Formula (2), R 21 is hydrogen, R 22 is a straight or branched-chain alkylene group having 1 to 3 carbon atoms, and R 23 is a straight or branched-chain alkyl group having 1 to 3 carbon atoms.
10. The medical apparatus according to claim 9 , wherein in Formula (2), R 22 is an ethylene, and R 23 is a methylene.
11. The medical apparatus according to claim 10 , wherein the total amount of the repeating unit (A) and the repeating unit (B) is 100 mole % with respect to all constituent units of the copolymer.