Compositions for treatment and/or prevention of autoimmune disorders
The invention provides compositions for treating or preventing T1D (T1D), the compositions comprising one or more antigen presenting cells (APC) that have been pulsed with one or more bacteria and/or components of the bacteria, wherein the bacteria or their components confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells. The subject invention also provides a method of treating or preventing T1D in a subject, the method comprising administering APC that have been pulsed with one or more bacteria and/or components of the bacteria and wherein the bacteria or their components confer upon the APCs the ability to inhibit the generation of diabetes-promoting T cells.
1. A method of treating or preventing type 1 Diabetes (TID), the method comprising administering to a human who has been diagnosed as having diabetes, or at risk for diabetes, an antigen presenting cell (APC) contacted with a suppressor of cytokine signaling-1 (SOCS1) protein peptide or mimetic inhibitor that antagonizes the activity of SOCS1 protein, wherein said contacting confers upon the APC the ability to inhibit the generation of diabetogenic T cells.
2. The method of claim 1 , wherein the APC is a dendritic cell (DC).
3. The method of claim 1 , wherein the peptide is selected from the group consisting of SOCS1-kinase inhibitory region (SOCS1-KIR) peptide, SOCS1-KIR2A, Tyrosine Kinase Inhibitory Peptide (TKIP), SOCS1-KIR dimer, JAK2 (1001-1013), and pJAK2(1001-1013).