Polymeric nanocarriers with light-triggered release mechanism
Near infrared radiation at a wavelength that induces resonance in water is used to remotely activate thermal plasticization of polymeric particles to trigger the release of encapsulated molecules from the particles. Nanocarriers formed from biocompatible hydrophilic polymers may be used to deliver encapsulated molecules to tissue with a reversible transition that allows repeated activations for extended release of the payload.
1. A method for delivering a payload, comprising:
encapsulating the payload in a nanocarrier comprising a hydrophilic polymer having no inherent light sensitivity, wherein the polymer is poly(lactic-co-glycolic) (PLGA);
hydrating the polymer to form nanodomains of water; and
exposing the nanocarrier to light having a wavelength corresponding to a water absorption band within the near infrared (NIR) region adapted to induce resonant photon interactions with the water to locally heat the polymer to induce a phase change in the polymer whereby the payload diffuses out of the nanocarrier.
2. The method of claim 1 , wherein the a wavelength is selected from the group consisting of 980 nm, 1200 nm, 1450 nm, and 1950 nm.
3. The method of claim 1 , wherein the PLGA has a lactide:glycolide ratio selected according to a desired release rate.
4. The method of claim 3 , wherein the lactide:glycolide ratio is selected from the group consisting of 50:50, 75:25, and 85:15.
5. The method of claim 3 , wherein the PLGA has a lactide:glycolide ratio selected according to a desired particle size.
6. The method of claim 5 , wherein the lactide:glycolide ratio is selected from the group consisting of 50:50, 75:25, and 85:15.
7. The method of claim 1 , wherein the payload comprises a therapeutic compound.
8. The method of claim 1 , wherein the payload comprises a dye.
9. The method of claim 1 , further comprising forming an aggregation of nanocarriers for delivery of the payload over an extended period of time.