Imidazole derivatives useful for controlling microbial growth
Disclosure is provided for 1,4,5-substituted amino imidazole compounds useful to control microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.
1. A method of reducing microbial growth on a substrate comprising the step of contacting a compound of Formula (I)(a)(i):
wherein:
R 2 is —(CH 2 ) a R 5 , wherein a is 0, and R 5 is:
wherein one of D 1 , D 2 , D 3 , D 4 or D 5 is alkyl or alkenyl, and the others are H;
R 3 is —(CH 2 ) b R 6 , wherein b is 0, and R 6 is phenyl; and
R 4 is unsubstituted C 1 -C 5 alkyl,
or a pharmaceutically acceptable salt or prodrug thereof,
to said substrate in an amount effective to reduce said microbial growth.
2. The method of claim 1 , wherein said microbial growth is Gram-positive bacterial growth.
3. The method of claim 2 , wherein said bacterial growth is Staphylococcus aureus.
4. The method of claim 2 , wherein said bacterial growth is methicillin-resistant Staphylococcus aureus (MRSA).
5. The method of claim 1 , wherein one of D 1 , D 2 , D 3 , D 4 or D 5 is C 1 -C 15 alkyl, and the others are H,
or a pharmaceutically acceptable salt or prodrug thereof.
6. The method of claim 1 , wherein one of D 1 , D 2 , D 3 , D 4 or D 5 is a C 1 , C 3 , C 5 , C 7 , C 9 or C 11 alkyl, and the others are H,
or a pharmaceutically acceptable salt or prodrug thereof.
7. The method of claim 1 , wherein said compound is:
or a pharmaceutically acceptable salt thereof.
8. The method of claim 1 , wherein said compound is:
or a pharmaceutically acceptable salt thereof.
9. The method of claim 1 , wherein said compound is:
or a pharmaceutically acceptable salt thereof.
10. A method for treating a bacterial infection in a subject in need thereof, comprising administering to said subject a compound of Formula (I)(a)(i):
wherein:
R 2 is —(CH 2 ) a R 5 , wherein a is 0, and R 5 is:
wherein one of D 1 , D 2 , D 3 , D 4 or D 5 is alkyl or alkenyl, and the others are H;
R 3 is —(CH 2 ) b R 6 , wherein b is 0, and R 6 is phenyl; and
R 4 is unsubstituted C 1 -C 5 alkyl,
or a pharmaceutically acceptable salt or prodrug thereof,
in an amount effective to reduce a bacterial component of said infection.
11. The method of claim 10 , wherein said bacterial component is Gram-positive bacteria.
12. The method of claim 10 , wherein said bacterial component is Staphylococcus aureus.
13. The method of claim 10 , wherein bacterial component is methicillin-resistant Staphylococcus aureus (MRSA).
14. The method of claim 10 , wherein a biocide is administered to said subject in combination with said compound.
15. The method of claim 14 , wherein the compound is administered to said subject in an amount effective to enhance the effects of the biocide.
16. The method of claim 10 , wherein one of D 1 , D 2 , D 3 , D 4 or D 5 is C 1 -C 15 alkyl, and the others are H,
or a pharmaceutically acceptable salt or prodrug thereof.
17. The method of claim 10 , wherein one of D 1 , D 2 , D 3 , D 4 or D 5 is a C 1 , C 3 , C 5 , C 7 , C 9 or C 11 alkyl, and the others are H,
or a pharmaceutically acceptable salt or prodrug thereof.
18. The method of claim 10 , wherein said compound is:
or a pharmaceutically acceptable salt thereof.
19. The method of claim 10 , wherein said compound is:
or a pharmaceutically acceptable salt thereof.
20. The method of claim 10 , wherein said compound is:
or a pharmaceutically acceptable salt thereof.