Seal element for anastomosis
A seal element for sealing between tissue lumens includes a first material for allowing tissue ingrowth and a second sealant material.
1. A seal element for positioning between tubular sections of tissue to be joined, the seal element comprising:
a first material that promotes tissue ingrowth, the first material being selected from the group consisting of a foam, a mesh, a non-woven structure, a perforated sheet and combinations thereof; and
a second material comprising a sealant at least partially surrounding the first material, the second material being compressible.
2. The seal element of claim 1 , wherein the first material is a porous material.
3. The seal element of claim 1 , wherein the first material is selected from the group consisting of glycolide, lactide, caprolactone, trimethylene carbonate, dioxanone, polyalkylene oxides, and combinations thereof.
4. The seal element of claim 1 , wherein the first material comprises a porous material having pores ranging in size from about 50 μm to about 200 μm.
5. The seal element of claim 1 , wherein the first material has a thickness ranging from about 0.010 inches to about 0.020 inches.
6. The seal element of claim 1 , wherein the second material is expandable.
7. The seal element of claim 1 , wherein the second material is a hydrophilic material.
8. The seal element of claim 1 , wherein the second material is derived from a monomer selected from the group consisting of methacrylic acid, acrylic acid, n-vinyl pyrrolidone, potassium sulfopropyl acrylate, potassium sulfopropyl methacrylate, acrylamide, dimethylacrylamide, 2-methacryloyloxyethyl phosphorylcholine, hydroxethylmethacrylate, 2-hydroxyethyl methacrylate and combinations thereof.
9. The seal element of claim 1 , wherein the second material is poly(2-hydroxyethyl methacrylate).
10. The seal element of claim 1 , wherein the second material comprises a surface having a pattern formed thereon.
11. The seal element of claim 1 , wherein at least one of the first or second materials further comprises at least one medically useful substance.
12. The seal element of claim 11 , wherein the at least one medically useful substance is selected from the group consisting of drugs, enzymes, growth factors, peptides, proteins, dyes, diagnostic agents, hemostasis agents, antimicrobials, antibiotics, anti-fungals, anti-virals, monoclonal antibodies, polyclonal antibodies, antimicrobial proteins/peptides, enzymes, gene therapy, viral particles, chemotherapeutics, anti-inflammatories, NSAIDS, steroids, telomerase inhibitors, growth factors, extracellular matrix molecules, cell adhesion molecules, polysaccharides and combinations thereof.
13. The seal element of claim 1 , further comprising a generally centrally located aperture.
14. The seal element of claim 1 , wherein the first material is disposed inwardly of the second material and the second material is configured to engage an exterior of the tissue to provide a seal.
15. The seal element of claim 1 , wherein the second material at least partially overlaps the first material.
16. The seal element of claim 1 , wherein the first material is thinner than the second material.
17. A seal element disposable between tissue lumens, the seal element being a disc comprising:
an inner first material that is porous and promotes tissue ingrowth;
an outer second material comprising a sealant at least partially surrounding the inner first material, the second material being poly(2-hydroxyethyl methacrylate); and
a center aperture.