Methods and compositions for the treatment of proliferative vascular disorders
The technology described herein is directed to methods and compositions for the treatment of proliferative vascular disorders, e.g. hemangioma. In some aspects, the methods and compositions described herein related to a mTOR inhibitor or nifedipine.
1. A method of treating infantile hemangioma, the method comprising:
administering a mTOR inhibitor; and
administering a beta-blocker.
2. The method of claim 1 , wherein the mTOR inhibitor is selected from the group consisting of:
everolimus; temsirolimus; and rapamycin.
3. The method of claim 1 , wherein the beta-blocker is selected from the group consisting of:
atenolol; nadolol; propranolol and timolol.
4. The method of claim 1 , wherein the i) mTOR inhibitor and ii) the beta-blocker are administered concomitantly.
5. The method of claim 1 , wherein one or more of the mTOR inhibitor, or beta-blocker are administered systemically.
6. The method of claim 1 , wherein one or more of the mTOR inhibitor, or beta-blocker are administered orally.
7. The method of claim 1 , wherein one or more of the mTOR inhibitor, or beta-blocker are administered intralesionally.
8. The method of claim 1 , wherein one or more of the mTOR inhibitor, or beta-blocker are administered topically.