Composition and method for treatment of depression and psychosis in humans
Compositions and methods tor the treatment of depression and psychoses in humans are disclosed. More particularly, the invention is directed to formulations containing antipsychotic and/or antidepressant medications and also containing an NMDAR antagonist. The present invention is also directed to methods for the treatment of humans suffering from depression and other psychoses, including, schizophrenia, by administration of the inventive compositions in antidepressant and/or antipsychotic effective amounts.
1. A composition for treating depression or psychosis with reduced akathisia side effects in a human in need of such treatment consisting essentially of:
an akathisia-producing effective amount of a first compound consisting of a selective 5-HT2A receptor antagonist/inverse agonist selected from the group consisting of eplivanserin (SR46.349) and pimavanserin (ACP-103); and
an effective amount of a second compound consisting of a selective NMDAR receptor antagonist, selected from the group consisting of D-CPPene and gavestinel,
wherein the composition is formulated as a tablet or capsule for systemic oral administration,
wherein the selective NMDAR receptor antagonist is a full NMDAR receptor antagonist; wherein the effective amount of the selective NMDAR receptor antagonist is sufficient to inhibit the akathisia-producing side effects of the first compound; and
wherein the NMDAR receptor antagonist binds to at least one of the glycine or glutamate binding sites.
2. The composition of claim 1 , wherein the composition is a sustained release formulation.