Methods and compositions for enhanced transungual delivery of AR-12
Methods and compositions for enhancing transungual delivery of AR-12 comprising administering AR-12 and permeation enhancers are provided.
1. A method of administering AR-12 to a nail comprising administering a composition comprising AR-12 and a permeation enhancer to a nail in an amount sufficient to achieve an AR-12 concentration of at least about 0.02 μg/mg in the nail plate.
2. The method of claim 1 , wherein the permeation enhancer is selected from the group consisting of dexpanthenol and polyethylene glycol 400.
3. The method of claim 2 , wherein the permeation enhancer comprises dexpanthenol and polyethylene glycol 400.
4. A method of administering AR-12 to a nail comprising administering a composition comprising AR-12 and a permeation enhancer to a nail in an amount sufficient to achieve a cumulative amount of AR-12 permeated across the nail plate of at least about 3 μg/cm2.
5. The method of claim 4 , wherein the permeation enhancer is selected from the group consisting of dexpanthenol and polyethylene glycol 400.
6. The method of claim 4 , wherein the permeation enhancer comprises dexpanthenol and polyethylene glycol 400.
7. A composition comprising AR-12 and dexpanthenol.
8. A composition comprising AR-12 polyethylene glycol 400.
9. A composition comprising AR-12 and dexpanthenol and polyethylene glycol 400.
10. The composition of claim 7 , wherein the concentration of dexpanthenol in the composition is about 5%.
11. The composition of claim 8 , wherein the concentration of polyethylene glycol in the composition is about 5%.
12. The composition of claim 9 , wherein the concentration of each of dexpanthenol and polyethylene glycol in the composition is about 5%.