Peptides and compositions for treatment of joint damage
The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.
1. An isolated polypeptide comprising SEQ ID NO: 28.
2. A pharmaceutical composition comprising the isolated polypeptide of claim 1 .
3. The pharmaceutical composition of claim 2 further comprising a buffer.
4. The pharmaceutical composition of claim 2 further comprising sucrose.
5. The pharmaceutical composition of claim 2 , wherein the composition comprises sucrose and a buffer.
6. An isolated polypeptide consisting of SEQ ID NO: 28.
7. A pharmaceutical composition comprising the isolated polypeptide of claim 6 .
8. The pharmaceutical composition of claim 7 further comprising a buffer.
9. The pharmaceutical composition of claim 7 further comprising sucrose.
10. The pharmaceutical composition of claim 7 , wherein the composition comprises sucrose and a buffer.