Compositions and methods for treating chronic inflammation and inflammatory diseases
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
1. A pharmaceutical composition comprising:
a) about 10% to 30% of a propionic acid derivative NSAID by weight of the pharmaceutical composition;
b) about 5% to about 15% of a polyethylene glycol (PEG) polymer by weight of the pharmaceutical composition;
c) about 20% to about 50% of a hard fat comprising a triglyceride or a triester of glycerol by weight of the pharmaceutical composition; and
d) about 10% to about 30% of a liquid fat comprising a mono-glyceride by weight of the pharmaceutical composition,
wherein the pharmaceutical composition is formulated to be a solid at a temperature of about 15° C. or lower and have a melting point temperature in the range of about 25° C. or higher.
2. The pharmaceutical composition according to claim 1 , wherein the propionic acid derivative NSAID is about 20% to about 30% by weight of the pharmaceutical composition.
3. The pharmaceutical composition according to claim 2 , wherein the propionic acid derivative NSAID is in an amount from about 25% to about 30% by weight of the pharmaceutical composition.
4. The pharmaceutical composition according to claim 1 , wherein the propionic acid derivative NSAID comprises an Alminoprofen, a Benoxaprofen, a Dexketoprofen, a Fenoprofen, a Flurbiprofen, an Ibuprofen, an Indoprofen, a Ketoprofen, a Loxoprofen, a Naproxen, an Oxaprozin, a Pranoprofen, or a Suprofen.
5. The pharmaceutical composition according to claim 1 , wherein the propionic acid derivative NSAID is a pharmaceutically-acceptable form of an Ibuprofen.
6. The pharmaceutical composition according to claim 1 , wherein the hard fat or the triester of glycerol is in an amount from about 30% to about 50% by weight of the pharmaceutical composition.
7. The pharmaceutical composition according to claim 6 , wherein the hard fat or the triester of glycerol is in an amount from about 35% to about 45% by weight of the pharmaceutical composition.
8. The pharmaceutical composition according to claim 1 , wherein the hard fat or the triester of glycerol has a melting point of about 40° C. to about 46° C.
9. The pharmaceutical composition according to claim 8 , wherein the hard fat comprises a mixture of saturated C 10 -C 18 triglycerides having a melting point of between 41° C. to 45° C.
10. The pharmaceutical composition according to claim 9 , wherein the hard fat comprises a mixture of saturated C 10 -C 18 triglycerides having a melting point of about 43° C.
11. The pharmaceutical composition according to claim 1 , wherein the liquid fat is in an amount from about 15% to about 25% by weight of the pharmaceutical composition.
12. The pharmaceutical composition according to claim 1 , wherein the liquid fat further comprises a diglyceride, a triglyceride, or any combination thereof.
13. The pharmaceutical composition according to claim 1 , wherein the monoglyceride is glyceryl monolinoleate.
14. The pharmaceutical composition according to claim 1 , wherein the PEG polymer is in an amount from about 8% to about 15% by weight of the pharmaceutical composition.
15. The pharmaceutical composition according to claim 14 , wherein the PEG polymer is in an amount from about 7% to about 13% by weight of the pharmaceutical composition.
16. The pharmaceutical composition according to claim 15 , wherein the pharmaceutically-acceptable PEG polymer is in an amount from about 8% to about 12% by weight of the pharmaceutical composition.
17. The pharmaceutical composition according to claim 16 wherein the PEG polymer is in an amount from about 9% to about 11% by weight of the pharmaceutical composition.
18. The pharmaceutical composition according to claim 1 , wherein the PEG polymer is a liquid PEG polymer.
19. The pharmaceutical composition according to claim 18 , wherein the pharmaceutically-acceptable PEG polymer is less than about 2,000 g/mol.
20. The pharmaceutical composition according to claim 19 , wherein the liquid PEG polymer is a PEG 100, a PEG 200, a PEG 300, a PEG 400, a PEG 500, a PEG 600, a PEG 700, a PEG 800, a PEG 900, a PEG 1000, or a combination thereof.