Bioresorbable and biocompatible compounds for surgical use
A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan.
1. A compound comprising a functionalized collagen covalently bonded directly to chitosan without the use of a crosslinking agent, wherein the chitosan has a degree of acetylation from about 35 to 50% and wherein the collagen is functionalized by oxidative cleavage.
2. A compound as in claim 1 wherein the functionalized collagen includes one or more reactive moieties selected from the group consisting of aldehydes, sulfones, vinylsulfones, isocyanates, and acid anhydrides.
3. The compound of claim 1 wherein the functionalized collagen includes one or more reactive moieties selected from the group consisting of —CO 2 N(COCH 2 ) 2 , —CO 2 N(COCH 2 ) 2 , —CO 2 H, —CHO, —CHOCH 2 , —N═C═O, —SO 2 CH═CH 2 , —N(COCH) 2 , and —S—S—(C 5 H 4 N).
4. The compound of claim 1 wherein the functionalized collagen is covalently bonded to at least a second chitosan with a degree of acetylation selected from about 0.5 to 60%.
5. An implant comprising a compound containing a functionalized collagen covalently bonded directly to chitosan without the use of a crosslinking agent, wherein the chitosan has a degree of acetylation from about 35 to 50% and wherein the collagen is functionalized by oxidative cleavage.
6. The implant of claim 5 comprising a sponge containing said compound.
7. The implant of claim 5 comprising a textile containing said compound.
8. The implant of claim 5 comprising a hydrogel containing said compound.
9. The implant of claim 5 comprising threads containing said compound.
10. The implant of claim 5 comprising a non knitted, non woven composite containing said compound.
11. The implant of claim 5 comprising a film containing said compound.
12. The implant of claim 5 comprising a mesh coated with a composition containing said compound.
13. A method of forming a bioresorbable compound comprising contacting a functionalized collagen with a glycosaminoglycan without the use of a crosslinking agent, wherein the glycosaminoglycan is chitosan having a degree of acetylation from about 35% to 50% and wherein the collagen is functionalized by oxidative cleavage, wherein a deionized water solution of functionalized collagen is combined to a deionized water solution of chitosan having a degree of acetylation from about 35% to 50% to allow the functionalized collagen to mix with the chitosan and form said compound.
14. The method of claim 13 , wherein the pH of the solution of functionalized collagen is adjusted between 2 and 7.5.
15. The method of claim 13 , wherein the pH of the solution of glycosaminoglycan is adjusted between 2 and 7.5.
16. The method of claim 14 , wherein the pH of the solution of glycosaminoglycan is adjusted between 2 and 7.5.