Oxygen generating biomaterial
View Patent ↗Certain embodiments include materials that carry oxygen and emit molecular oxygen upon heating. The approach reported here uses thermal decomposition of organic endoperoxide compounds to produce singlet oxygen. In certain aspects the oxygen carrier comprises an organic compound either alone or contained in a polymeric carrier or other carrier material that is used to form a coating, layer, or bulk substance that can be a solid, a gel or a fluid. The oxygen-carrier is most conveniently prepared by oxidation of a precursor compound, the structure of which determines its thermal stability and thus how rapidly oxygen is released at any given temperature.
1. A method of treating a wound comprising:
contacting the wound with a material of with a material comprising a thermolytic compound that generates singlet oxygen, wherein said thermolytic compound is a polycyclic aromatic endoperoxide.
2. The method of claim 1 , wherein said polycyclic aromatic endoperoxide is a methyl substituted naphthalene endoperoxide.
3. The method of claim 2 , wherein said methyl substituted naphthalene endoperoxide is trimethyl or tetramethyl naphthalene endoperoxide.
4. The method of claim 3 , wherein said methyl substituted naphthalene is selected from the group consisting of: 1,4-dimethylnaphthalene-1,4-endoperoxide; 1,8-dimethylnaphthalene-1,4-endoperoxide; 1,2,4-trimethylnaphthalene-1,4-endoperoxide; 1,4,5-trimethylnaphthalene-1,4-endoperoxide; and 1,2,3,4-tetramethylnaphthalene 1 , 4 -endoperoxide.
5. The method of claim 1 , wherein said polycyclic aromatic endoperoxide is rubrene endoperoxide.
6. The method of claim 1 , wherein said material comprises a combination of 2 or more polycyclic aromatic endoperoxides.
7. The method of claim 6 , wherein said material comprises a methyl substituted naphthalene endoperoxide and rubrene endoperoxide.
8. The method of claim 1 , wherein said material further comprises a singlet oxygen quencher.
9. The method of claim 8 , wherein said singlet oxygen quencher is beta-carotene or 1,3-diphenylisobenzofuran.
10. The method of claim 1 , further comprising a carrier.
11. The method of claim 10 , wherein the carrier is a solid, gel, hydrogel, or semisolid.
12. The method of claim 11 , wherein the carrier is a tissue scaffold.
13. The method of claim 12 , wherein the tissue scaffold is comprised in a dental implant.
14. The method of claim 13 , wherein the dental implant is a sub-gingival implant.