Heteroaryls and uses thereof
The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , L 1 , L 2 , m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , which is
or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
6. The pharmaceutical composition of claim 5 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
7. The pharmaceutical composition of claim 5 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
8. The pharmaceutical composition of claim 5 , wherein the compound is
or a pharmaceutically acceptable salt thereof.