Enhanced nuclear spin polarization
View Patent ↗The polarization of nuclear spins of a material may be enhanced by encapsulating the material within a reverse micelle.
1. A method comprising:
hydrating a material;
encapsulating the hydrated material within a reverse micelle, the reverse micelle comprising a radical;
dissolving the reverse micelle in a low dielectric solvent adapted to avoid and/or mitigate dielectric loss;
exposing the reverse micelle to a magnetic field; and
concurrent with exposing the reverse micelle to the magnetic field, imparting energy from the radical to the material by applying electromagnetic radiation to the reverse micelle so as to enhance detection of characteristics of the material without causing catastrophic heating of the material.
2. The method of claim 1 , wherein the radical has an electron spin.
3. The method of claim 1 , wherein the material comprises a water-soluble molecule having a nuclear spin.
4. The method of claim 1 , wherein the reverse micelle is shuttled from a first magnetic field to a second magnetic field.
5. The method of claim 1 , wherein a second magnetic field having a field strength less than a field strength of the magnetic field is applied to the reverse micelle concurrent with imparting energy from the radical to the material by applying electromagnetic radiation to the reverse micelle.
6. The method of claim 1 , wherein a frequency of the electromagnetic radiation is greater than 1 GHz.
7. The method of claim 1 , wherein the reverse micelle increases a residence time of water on a surface of the encapsulated material.
8. The method of claim 1 , wherein the material comprises a water soluble molecule.
9. The method of claim 3 , wherein the water-soluble molecule comprises at least one of a protein, polysaccharide, polypeptide, or a polynucleotide.
10. The method of claim 2 , wherein the radical is embedded in the reverse micelle.
11. The method of claim 2 , wherein the radical is embedded in a surfactant layer of the reverse micelle.
12. The method of claim 2 , wherein the radical is located in a water core of the reverse micelle.
13. The method of claim 2 , wherein the radical is attached to the hydrated material.
14. A method comprising:
hydrating a material;
encapsulating the hydrated material within a reverse micelle, the reverse micelle comprising a radical;
dissolving the reverse micelle in a low dielectric solvent;
exposing the reverse micelle to a magnetic field; and
concurrent with exposing the reverse micelle to the magnetic field, imparting energy from the radical to the material by applying electromagnetic radiation to the reverse micelle,
wherein the reverse micelle comprises a surfactant mixture including 1-decanoyl-rac-glycerol (10MAG) and lauryldimethylamine-N-oxide (LDAO).
15. The method of claim 2 , wherein the radical comprises a nitroxide radical.