Multiplexed electrostatic linear ion trap
Systems and methods are provided for performing multiplex electrostatic linear ion trap mass spectrometry. A first beam of ions is received and the first beam is split into N beams of ions using a beam splitter. N is two or more. Ions are received from only one of the N beams of ions at each entrance aperture of N entrance apertures of an electrostatic linear ion trap (ELIT). Ions from each entrance aperture of the N entrance apertures are trapped in separate linear flight paths using the ELIT, producing N separate linear flight paths. Ion oscillations in the N separate linear flight paths are measured at substantially the same time using the ELIT. The ELIT uses two concentric mirrors with N apertures to trap ions in the N separate linear flight paths. The ELIT uses an image current detector with N apertures to the measure the ion oscillations.
1. A mass analyzer for performing multiplex electrostatic linear ion trap mass spectrometry, comprising:
a beam splitter that receives a beam of ions and splits the beam into N beams of ions, wherein N is two or more; and
an electrostatic linear ion trap with N entrance apertures that
receives ions from only one of the N beams of ions at each entrance aperture of the N entrance apertures,
traps ions from each entrance aperture of the N entrance apertures in separate linear flight paths, producing N separate linear flight paths; and
measures ion oscillations in the N separate linear flight paths at substantially the same time.
2. The mass analyzer of claim 1 , wherein the beam splitter splits the beam into N beams of ions so that the number of ions in each of the N beams of ions is less than the number of ions in the beam.
3. The mass analyzer of claim 1 ,
wherein the electrostatic linear ion trap further includes a first concentric mirror with one or more electrodes, a second concentric mirror with one or more electrodes, and an image current detector between the first concentric mirror and the second concentric mirror and
wherein each electrode of the first concentric mirror includes N apertures, each electrode of the second concentric mirror includes N apertures, and the image current detector includes N apertures.
4. The mass analyzer of claim 3 ,
wherein the N apertures of each electrode of the first concentric mirror, the N apertures of each electrode of the second concentric mirror, and the N apertures of the image current detector are linearly aligned with the N entrance apertures to produce the N separate linear ion flight paths.
5. The mass analyzer of claim 4 ,
wherein the image current detector measures ion oscillations between the first concentric mirror and the second concentric mirror in the N separate linear ion flight paths at substantially the same time.
6. The mass analyzer of claim 1 , wherein the beam splitter is part of the electrostatic linear ion trap.
7. The mass analyzer of claim 1 , wherein the beam splitter comprises a collision cell that includes N quadrupole arrays that eject ions from the collision cell through an exit lens with N apertures.
8. The mass analyzer of claim 3 , wherein the N apertures of each electrode of the first concentric mirror, the N apertures of each electrode of the second concentric mirror, and the N apertures of the image current detector are evenly spaced along and centered on a circumference of a circle.
9. The mass analyzer of claim 3 , wherein the N apertures of each electrode of the first concentric mirror, the N apertures of each electrode of the second concentric mirror, and the N apertures of the image current detector are aligned so the ions in each of the N separate linear ion flight paths have the same phase.
10. A method for performing multiplex electrostatic linear ion trap mass spectrometry, comprising:
receiving a first beam of ions and splitting the first beam into N beams of ions using a beam splitter, wherein N is two or more;
receiving ions from only one of the N beams of ions at each entrance aperture of N entrance apertures of an electrostatic linear ion trap;
trapping ions from each entrance aperture of the N entrance apertures in separate linear flight paths using the electrostatic linear ion trap, producing N separate linear flight paths; and
measuring ion oscillations in the N separate linear flight paths at substantially the same time using the electrostatic linear ion trap.
11. The method of claim 10 , wherein the beam splitter splits the beam into N beams of ions so that the number of ions in each of the N beams of ions is less than the number of ions in the beam.
12. The method of claim 10 , wherein
wherein the electrostatic linear ion trap further includes a first concentric mirror with one or more electrodes, a second concentric mirror with one or more electrodes, and an image current detector between the first concentric mirror and the second concentric mirror and
wherein each electrode of the first concentric mirror includes N apertures, each electrode of the second concentric mirror includes N apertures, and the image current detector includes N apertures.
13. The method of claim 12 , wherein
wherein the N apertures of each electrode of the first concentric mirror, the N apertures of each electrode of the second concentric mirror, and the N apertures of the image current detector are linearly aligned with the N entrance apertures to produce the N separate linear ion flight paths.
14. The method of claim 13 ,
wherein the image current detector measures ion oscillations between the first concentric mirror and the second concentric mirror in the N separate linear ion flight paths at substantially the same time.
15. The method of claim 10 , wherein the beam splitter is part of the electrostatic linear ion trap.
16. The method of claim 10 , wherein the beam splitter comprises a collision cell that includes N quadrupole arrays that eject ions from the collision cell through an exit lens with N apertures.
17. The method of claim 12 , wherein the N apertures of each electrode of the first concentric mirror, the N apertures of each electrode of the second concentric mirror, and the N apertures of the image current detector are evenly spaced along and centered on a circumference of a circle.
18. The method of claim 12 , wherein the N apertures of each electrode of the first concentric mirror, the N apertures of each electrode of the second concentric mirror, and the N apertures of the image current detector are aligned so the ions in each of the N separate linear ion flight paths have the same phase.