Treatment of corneal neovascularization
There is provided inter alia a compound which is an NK-1 receptor antagonist for use in the treatment or prevention of CNV. There is also provided a compound which is an NK-1 antagonist for use in the treatment of chemical burns of the eye particularly alkali burns of the eye. There is also provided a pharmaceutical composition for topical administration to the eye comprising an NK-1 antagonist and an antibiotic agent.
1. A method of treating corneal neovascularization (“CNV”) which comprises administering to a subject in need thereof a therapeutically effective amount of an NK-1 antagonist wherein the NK-1 antagonist is selected from the group consisting of a fosaprepitant, aprepitant, lanepitant and befetupitant and wherein the NK-1 receptor antagonist is administered topically to the cornea.
2. A method according to claim 1 wherein CNV is concurrent or consequential to an inflammatory condition.
3. A method according to claim 1 wherein CNV is caused by one of the following conditions: bacterial infection, viral infection, Chlamydia trachomatis infection, infectious keratitis including herpes simplex keratitis, viral interstitial keratitis, infections caused by staphylococcus, streptococcus, Pseudomonas or microbial keratoconjunctivitis, Pseudomonas aeruginosa infection, chemical or physical insult of the eye, degenerative and traumatic disorders, dry eye, progressive corneal vascularization caused by graft-versus-host disease, limbal stem cell deficiency (including idiopathic, traumatic, aniridia, autoimmune polyendocrinopathy), Stevens-Johnson syndrome, ocular pemphigoid, recurrent pterygium following surgery, extended wearing of hydrogel contact lenses.
4. A method according to claim 1 wherein the NK-1 antagonist is aprepitant or a pharmaceutically acceptable salt thereof.
5. A method according to claim 1 wherein the NK-1 antagonist is befetupitant or a pharmaceutically acceptable salt thereof.
6. A method according to claim 1 wherein the NK-1 antagonist is lanepitant or a pharmaceutically acceptable salt thereof.
7. A method according to claim 1 wherein the NK-1 antagonist is administered in combination, by the same or a different route, with one or more further therapeutically active agents.
8. A method according to claim 7 wherein at least one of the one or more further therapeutically active agents is administered topically to the eye.
9. A method according to claim 1 wherein the NK-1 antagonist is fosaprepitant or a pharmaceutically acceptable salt thereof.