Methods and devices for drug delivery to ocular tissue using microneedle
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
1. A method, comprising:
inserting a microneedle into a suprachoroidal space of an eye at an insertion site without the microneedle penetrating through the choroid, the microneedle comprising a drug formulation which comprises a drug; and
forming a drug depot at the insertion site in the suprachoroidal space for controlled release of the drug to an ocular tissue.
2. The method of claim 1 , wherein the drug formulation is in the form of a coating on the microneedle.
3. The method of claim 2 , wherein the coating dissolves or detaches from the microneedle upon insertion into the suprachoroidal space.
4. The method of claim 1 , wherein the drug depot comprises microparticles or nanoparticles, the microparticles or nanoparticles comprising the drug.
5. The method of claim 1 , wherein the drug is an anti-inflammatory drug.
6. The method of claim 1 , wherein the insertion site is at about an equator of the eye or between the equator and a limbus of the eye.
7. The method of claim 1 , wherein the inserting the microneedle into the suprachoroidal space of the eye includes inserting the microneedle through a sclera of the eye at an angle of about 90 degrees.
8. The method of claim 1 , wherein the microneedle is a solid microneedle.
9. The method of claim 1 , wherein the microneedle is a hollow microneedle.