Methods of colchicine administration
The invention provides improved methods for coadministration of colchicine with drugs metabolized by CYP3A4 (anciently referred to as cytochrome P450 isozyme 3A4) or the P-glycoprotein transporter, but not both. The method enables non-toxic coadministration of colchicine and the second drug at their ordinary levels safely and effectively without reducing the dose or frequency for either drug.
1. A method of administering a fixed maintenance dose of colchicine in a patient concomitantly administered voriconazole without dose reduction of colchicine, comprising inducing in said patient a pharmacokinetic profile of colchicine selected from:
a) a pharmacokinetic profile of colchicine comprising a mean C max of 2058.2±44.9% pg/mL, a median T max of 1.5±35.4% hours, a mean AUC T of 20730.8±36.9% pg·h/mL where T equals 72 hours, a mean AUC ∞ of 24100.1±37.3% pg·h/mL, and a mean elimination half life of 31.30 hours±17.0%; and
b) a pharmacokinetic profile of colchicine comprising a C max of 1834.9±30.8% pg/mL (geometric least squares means), an AUC T of 19502.6±28.0% pg·h/mL (geometric least squares mean) where T equals 72 hours, and an AUC ∞ of 22663.5±27.2% pg·h/mL (geometric least squares mean);
wherein the mean AUC T or AUC T (geometric least squares mean) of colchicine in the pharmacokinetic profile of the patient is about the same as a mean AUC T or AUC T (geometric least squares mean) of colchicine, respectively, in a pharmacokinetic profile in the patient when colchicine is administered in the same fixed maintenance dose without concomitant administration of voriconazole.
2. The method of claim 1 , comprising inducing in said patient a pharmacokinetic profile of colchicine comprising a mean C max of 2058.2 pg/mL, a median T max of 1.5 hours, a mean AUC T of 20730.8 pg·h/mL where T equals 72 hours, a mean AUC ∞ of 24100.1 pg·h/mL, and a mean elimination half life of 31.30 hours.
3. The method of claim 1 , comprising inducing in said patient a pharmacokinetic profile of colchicine comprising a C max of 1834.9 pg/mL (geometric least squares mean), an AUC T of 19502.6 pg·h/mL (geometric least squares mean) where T equals 72 hours, and an AUC ∞ of 22663.5 pg·h/mL (geometric least squares mean).
4. The method of claim 1 for the prevention of gout.
5. The method of claim 1 , wherein the fixed maintenance dose of colchicine is 0.6 mg/day.
6. The method of claim 1 , wherein the voriconazole is administered in a dose of 200 mg/day to 400 mg/day.
7. A method of administering a fixed maintenance dose of colchicine to a patient concomitantly administered voriconazole, comprising inducing in the patient following concomitant administration of colchicine and voriconazole a pharmacokinetic profile comprising an AUC T of colchicine that is about 104% to about 110% of an AUC T of colchicine in a pharmacokinetic profile of the patient following administration of the same fixed maintenance dose of colchicine without concomitant administration of voriconazole.
8. The method of claim 7 , wherein the pharmacokinetic profile in the patient following concomitant administration of colchicine and voriconazole comprises a mean C max of colchicine that is less than the mean C max of colchicine in the patient following administration of colchicine without concomitant administration of voriconazole.
9. The method of claim 7 , wherein the pharmacokinetic profile in the patient following concomitant administration of colchicine and voriconazole comprises a mean C max of colchicine of about 2100 pg/mL.
10. The method of claim 7 , wherein the pharmacokinetic profile in the patient following concomitant administration of colchicine and voriconazole comprises a T max of colchicine of about 1.5 hours.
11. The method of claim 7 , wherein the pharmacokinetic profile in the patient following concomitant administration of colchicine and voriconazole comprises an AUC T of colchicine of about 21000 pg·h/mL.
12. The method of claim 7 , wherein the pharmacokinetic profile in the patient following concomitant administration of colchicine and voriconazole comprises an elimination half-life of colchicine of about 31 hours.
13. The method of claim 7 , wherein the fixed maintenance dose of colchicine is 0.6 mg/day to 1.2 mg/day and wherein the voriconazole is administered at a dose of from 200 mg/day to 400 mg/day.
14. The method of claim 13 , wherein the fixed maintenance dose of colchicine is 0.6 mg/day and the voriconazole is administered at a dose of 400 mg/day.
15. A method of administering a fixed maintenance dose of colchicine to a patient concomitantly administered voriconazole, comprising inducing in the patient following concomitant administration of colchicine and voriconazole a pharmacokinetic profile comprising a geometric least squares mean AUC T of colchicine that is 89% to 133% of the geometric least squares mean AUC T of colchicine in the pharmacokinetic profile of the patient following administration of the same fixed maintenance dose of colchicine without concomitant administration of voriconazole.
16. The method of claim 15 , wherein the pharmacokinetic profile in the patient following concomitant administration of colchicine and voriconazole comprises a geometric least squares mean AUC ∞ of colchicine that is 91% to 135% of the geometric least squares mean AUC ∞ of colchicine in the pharmacokinetic profile of the patient following administration of colchicine without concomitant administration of voriconazole.
17. The method of claim 15 , wherein the pharmacokinetic profile in the patient following concomitant administration of colchicine and voriconazole comprises a geometric least squares mean C max of colchicine that is 64% to 99% of the geometric least squares mean C max of colchicine in the pharmacokinetic profile of the patient following administration of colchicine without concomitant administration of voriconazole.
18. A method of administering a fixed maintenance dose of colchicine in a patient concomitantly administered a second compound selected from fluconazole and cimetidine without dose reduction of colchicine, comprising inducing in said patient a pharmacokinetic profile of colchicine selected from:
(i) when the second compound is fluconazole:
a) a pharmacokinetic profile of colchicine comprising a mean C max of 2299.2±57.6% pg/mL, a median T max of 1.38±25.4% hours, a mean AUC T of 21270.7±33.6% pg·h/mL where T equals 72 hours, and a mean elimination half life of 34.51±14.8% hours; and
b) a pharmacokinetic profile of colchicine comprising a C max of 2046.3±27.1% pg/mL (geometric least squares means), an AUC T of 20364.2±22.4% pg·h/mL (geometric least squares mean) where T equals 72 hours, and an AUC ∞ of 24386.8±22.5% pg·h/mL (geometric least squares mean); and
(ii) when the second compound is cimetidine:
a) a pharmacokinetic profile of colchicine comprising a mean C max of 2108.7±50.2% pg/mL, a median T max of 1.03±30.2% hours, a mean AUC T of 18082.1±41.6% pg·h/mL where T equals 72 hours, and a mean elimination half life of 31.54±11.1% hours; and
b) a pharmacokinetic profile of colchicine comprising a C max of 1878.1±29.3% pg/mL (geometric least squares means), an AUC T of 16719.0±18.7% pg·h/mL (geometric least squares mean) where T equals 72 hours, and an AUC ∞ of 19334.3±19.4% pg·h/mL (geometric least squares mean);
wherein the mean AUC T or AUC T (geometric least squares mean) of colchicine in the pharmacokinetic profile of the patient is about the same as a mean AUC T or AUC T (geometric least squares mean) of colchicine, respectively, in a pharmacokinetic profile in the patient when colchicine is administered in the same fixed maintenance dose without concomitant administration of the second compound.