IP Library › Granted Patent US 9,796,711

Granted Patent B2

US 9,796,711 · App. 15/287,922 · Granted Oct 24, 2017

Substituted pyrazolo[3,4-

Inventors: Rhalid Akkari (Pantin, FR); Luke Jonathan Alvey (Versailles, FR); Xavier Marie Bock (Roaminville, FR); Pieter Isabelle Roger Claes (Gentbrugge, BE); Marlon D. Cowart (Round Lake Beach, IL); Elsa De Lemos (Paris, FR); Nicolas Desroy (Massy, FR); Béranger Duthion (Paris, FR); Gregory A. Gfesser (Lindenhurst, IL); Romain Luc Marie Gosmini (Savigny-sur-Orge, FR); Christopher Gaëtan Housseman (Montreuil, FR); Koen Karel Jansen (Turnhout, BE); Jianguo Ji (Libertyville, IL); Philip R. Kym (Libertyville, IL); Jean-Michel Lefrancois (Le Raincy, FR); Oscar Mammoliti (Mechelen, BE); Christel Jeanne Marie Menet (Brussels, BE); Gregory John Robert Newsome (Neuilly Plaisance, FR); Adeline Marie Elise Palisse (Brussels, BE); Sachin V Patel (Round Lake, IL); Mathieu Rafaël Pizzonero (Voisins le Bretonneux, FR); Anurupa Shrestha (Vernon Hills, IL); Elizabeth C. Swift (Highland Park, IL); Steven Emiel Van der Plas (Steenhuffel, BE); Xueqing Wang (Northbrook, IL)

Assignees: AbbVie S.á.r.l.; Galapagos NV

C07D471/04 A61K31/437 A61K31/496 A61K31/506 A61K31/5377 A61K31/541 A61K45/06 C07D519/00

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 9,796,711
App. No.: 15/287,922
Granted: Oct 24, 2017
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The present invention provides for compounds of formula (I) wherein R 1 , R 2 , R 3 , and R 4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).

Claims (1079)

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof,

wherein

R 1 is G 1A , -G 1B -G 1C , -G 1B -L 1A -G 1C , C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, —(C 1 -C 6 alkylenyl)-CN, —(C 1 -C 6 alkylenyl)-G 1D , or -G 1D —O-benzyl;

L 1A is —O— or —O—(C 1 -C 3 alkylenyl)-; wherein the left end of the L 1A moiety is attached to G 1B ;

G 1A is phenyl 5-6 membered monocyclic heteroaryl, 4-7 membered monocyclic heterocycle, fused bicyclic heterocycle, or C 3 -C 6 monocyclic cycloalkyl; wherein each G 1A is optionally substituted with 1, 2, 3, or 4 independently selected R 1a groups;

G 1B is phenyl or 5-6 membered monocyclic heteroaryl; wherein each G 1B is optionally substituted with 1, 2, 3, or 4 independently selected R 1b groups;

G 1C is 4-7 membered monocyclic heterocycle which is optionally substituted with 1, 2, 3, or 4 independently selected R 1c groups;

G 1D , at each occurrence, is a 4-7 membered monocyclic heterocycle, 5-6 membered monocyclic heteroaryl, or a C 3 -C 6 monocyclic cycloalkyl; wherein each G 1D is optionally substituted with 1, 2, 3, or 4 independently selected R 1d groups;

R 2 is C 2 -C 4 alkenyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —OR 2xa , —(C 1 -C 6 alkylenyl)-OR 2xb , —(C 1 -C 6 alkylenyl)-N(R 2xb ) 2 , —C(O)OR 2xb , —C(O)N(R 2xb ) 2 , or -G 2A ;

R 2xa is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or G 2B ;

R 2xb , at each occurrence, is independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

G 2A and G 2B are each independently 4-7 membered monocyclic heterocycle or C 3 -C 6 monocyclic cycloalkyl; wherein G 2A and G 2B are each optionally substituted with 1, 2, or 3 independently selected R 2a groups;

R 3 is halogen, G 3A , -G 3B -L 1 -G 3C , -G 3B -L 3 -G 3C -L 4 -G 3F , —(C 1 -C 6 alkylenyl)-G 3E , —OR 3a , —N(R 3a )(R 3b ), —N(R 3b )C(O)G 3D , or —C(O)G 3D ;

R 3a , at each occurrence, is independently G 3E , C 1 -C 6 haloalkyl, or C 1 -C 6 alkyl; wherein the C 1 -C 6 haloalkyl and the C 1 -C 6 alkyl are each optionally substituted with one or two substituents independently selected from the group consisting of G 3E , —OR 3xa , —C(O)G 3D , —N(R 3xb ) 2 , and —S(O) 2 R 3xc ;

R 3xa , R 3xb , and R 3xc , at each occurrence, are each independently hydrogen, C 1 -C 6 haloalkyl, C 1 -C 6 alkyl, G 3E , —(C 1 -C 6 alkylenyl)-OR 3ya , or —(C 1 -C 6 alkylenyl)-N(R 3ya ) 2 ; wherein R 3ya , at each occurrence, is independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

R 3b , at each occurrence, is hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

L 1 is a bond, C 1 -C 6 alkylenyl, (C 1 -C 6 alkylenyl) r -L 2 -(C 1 -C 6 alkylenyl) s , or O—(C 1 -C 6 alkylenyl)-C(O), wherein the left end of the L 1 moiety is attached to G 3B ;

L 2 is O, N(R x ), C(O), N(R x )C(O), or C(O)N(R x ); wherein each R x is independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

L 3 is a bond or C 1 -C 6 alkylenyl;

L 4 is a bond, C 1 -C 6 alkylenyl, O, N(R 2x ), C(O), N(R 2x )C(O), or C(O)N(R 2x ); wherein each R 2x is independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

r is 0 or 1;

s is 0 or 1;

G 3A , G 3B , and G 3C , are each independently C 3 -C 11 cycloalkyl, phenyl, 5-6 membered monocyclic heteroaryl, or 4-11 membered heterocycle, wherein G 3A , G 3B , and G 3C are each optionally substituted with 1, 2, 3, or 4 independently selected R e groups;

G 3D , at each occurrence, is 4-7 membered monocyclic heterocycle which is optionally substituted with 1, 2, 3, or 4 independently selected R e groups;

G 3E , at each occurrence, is independently C 3 -C 8 monocyclic cycloalkyl or 4-11 membered heterocycle; wherein each G 3E is optionally substituted with 1, 2, 3, or 4 substituents independently selected from the group consisting of R e and G 3F ;

G 3F , at each occurrence, is independently a 4-7 membered monocyclic heterocycle or a C 3 -C 6 monocyclic cycloalkyl; wherein each G 3F is optionally substituted with 1, 2, 3, or 4 independently selected R e groups;

R e , at each occurrence, is independently C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halogen, oxo, —CN, —N 3 , NO 2 , —OR f , —OC(O)R g , —OC(O)NR f R h , —SR f , —S(O) 2 R f , —S(O) 2 NR f R h , —C(O)R f , —C(O)OR f , —C(O)NR f R h , —C(O)N(R h )S(O) 2 R f , —N(R f ) 2 , —N(R h )C(O)R f , —N(R h )S(O) 2 R g , —N(R h )C(O)O(R g ), —N(R h )C(O)NR f R h , or —N(R h )S(O) 2 NR f R h ; wherein the C 1 -C 6 haloalkyl and the C 1 -C 6 alkyl are each optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen, —CN, NO 2 , —OR f , —OC(O)R g , —OC(O)NR f R h , —SR f , —S(O) 2 R f , —S(O) 2 NR f R h , —C(O)R, —C(O)OR, —C(O)NR f R h , —C(O)N(R h )S(O) 2 R f , —N(R f ) 2 , —N(R h )C(O)R f , —N(R h )S(O) 2 R g , —N(R h )C(O)O(R g ), —N(R h )C(O)NR f R h , and —N(R h )S(O) 2 NR f R h ;

R f , at each occurrence, is independently hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, —(C 1 -C 6 alkylenyl)-CN, —(C 1 -C 6 alkylenyl)-OR m , —(C 1 -C 6 alkylenyl)-OC(O)R n , —(C 1 -C 6 alkylenyl)-OC(O)N(R m ) 2 , —(C 1 -C 6 alkylenyl)-SR m , —(C 1 -C 6 alkylenyl)-S(O) 2 R m , —(C 1 -C 6 alkylenyl)-S(O) 2 N(R m ) 2 , —(C 1 -C 6 alkylenyl)-C(O)R m , —(C 1 -C 6 alkylenyl)-C(O)OR m , —(C 1 -C 6 alkylenyl)-C(O)N(R m ) 2 , —(C 1 -C 6 alkylenyl)-C(O)N(R m )S(O) 2 R n , —(C 1 -C 6 alkylenyl)-N(R m ) 2 , —(C 1 -C 6 alkylenyl)-N(R m )C(O)R n , —(C 1 -C 6 alkylenyl)-N(R m )S(O) 2 R n , —(C 1 -C 6 alkylenyl)-N(R m )C(O)O(R n ), —(C 1 -C 6 alkylenyl)-N(R m )C(O)N(R m ) 2 , or —(C 1 -C 6 alkylenyl)-N(R m )S(O) 2 N(R m ) 2 ;

R g , at each occurrence, is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, C 1 -C 6 haloalkyl, —(C 1 -C 6 alkylenyl)-CN, —(C 1 -C 6 alkylenyl)-OR m , —(C 1 -C 6 alkylenyl)-OC(O)R n , —(C 1 -C 6 alkylenyl)-OC(O)N(R m ) 2 , —(C 1 -C 6 alkylenyl)-SR m , —(C 1 -C 6 alkylenyl)-S(O) 2 R m , —(C 1 -C 6 alkylenyl)-S(O) 2 N(R m ) 2 , alkylenyl)-C(O)R m , —(C 1 -C 6 alkylenyl)-C(O)OR m , —(C 1 -C 6 alkylenyl)-C(O)N(R m ) 2 , —(C 1 -C 6 alkylenyl)-C(O)N(R m )S(O) 2 R n , —(C 1 -C 6 alkylenyl)-N(R m ) 2 , —(C 1 -C 6 alkylenyl)-N(R m )C(O)R n , —(C 1 -C 6 alkylenyl)-N(R m )S(O) 2 R n , —(C 1 -C 6 alkylenyl)-N(R m )C(O)O(R″), —(C 1 -C 6 alkylenyl)-N(R m )C(O)N(R m ) 2 , or —(C 1 -C 6 alkylenyl)-N(R m )S(O) 2 N(R m ) 2 ;

R h , at each occurrence, is independently hydrogen, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or —(C 1 -C 6 alkylenyl)-OR m ;

R 1a , R 1b , R 1c , R 1d , and R 2a , at each occurrence, are each independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, halogen, C 1 -C 6 haloalkyl, oxo, —CN, NO 2 , —OR m , —OC(O)R n , —OC(O)N(R m ) 2 , —SR m , —S(O) 2 R m , —S(O) 2 N(R m ) 2 , —C(O)R m , —C(O)OR m , —C(O)N(R m ) 2 , —C(O)N(R m )S(O) 2 R n , —N(R m ) 2 , —N(R m )(alkoxyalkyl), —N(alkoxyalkyl) 2 , —N(R m )C(O)R n , —N(R m )S(O) 2 R n , —N(R m )C(O)O(R n ), —N(R m )C(O)N(R m ) 2 , —N(R m )S(O) 2 N(R m ) 2 , —(C 1 -C 6 alkylenyl)-CN, —(C 1 -C 6 alkylenyl)-OR m , —(C 1 -C 6 alkylenyl)-OC(O)R n , —(C 1 -C 6 alkylenyl)-OC(O)N(R m ) 2 , —(C 1 -C 6 alkylenyl)-SR m , —(C 1 -C 6 alkylenyl)-S(O) 2 R m , —(C 1 -C 6 alkylenyl)-S(O) 2 N(R m ) 2 , —(C 1 -C 6 alkylenyl)-C(O)R m , —(C 1 -C 6 alkylenyl)-C(O)OR m , —(C 1 -C 6 alkylenyl)-C(O)N(R m ) 2 , —(C 1 -C 6 alkylenyl)-C(O)N(R m )S(O) 2 R n , —(C 1 -C 6 alkylenyl)-N(R m ) 2 , —(C 1 -C 6 alkylenyl)-N(R m )C(O)R n , —(C 1 -C 6 alkylenyl)-N(R m )S(O) 2 R n , —(C 1 -C 6 alkylenyl)-N(R m )C(O)O(R n ), —(C 1 -C 6 alkylenyl)-N(R m )C(O)N(R n ) 2 , or —(C 1 -C 6 alkylenyl)-N(R m )S(O) 2 N(R n ) 2 ;

R m , at each occurrence, is independently hydrogen, C 1 -C 6 alkyl, or C 1 -C 6 haloalkyl;

R n , at each occurrence, is independently C 1 -C 6 alkyl or C 1 -C 6 haloalkyl; and

R 4 is hydrogen, C 1 -C 3 alkyl, or C 1 -C 3 haloalkyl;

with the proviso that when R 1 is C 1 -C 6 alkyl or G 1A , wherein G 1A is optionally substituted phenyl, optionally substituted 5-6 membered monocyclic heteroaryl, or optionally substituted 4-7 membered monocyclic heterocycle, R 2 is C 1 -C 6 alkyl, and R 3 is G 3A , then G 3A is not optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl.

2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A , -G 1B -G 1C , C 1 -C 6 haloalkyl, or C 1 -C 6 alkyl.

3. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A .

4. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is -G 1B -G 1C .

5. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 2 is C 2 -C 4 alkenyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —OR 2xa , or G 2A .

6. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 2 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or G 2A .

7. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 3 is G 3A , -G 3B -L 1 -G 3C , —OR 3a , or —N(R 3a )(R 3b ).

8. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A or -G 1B -G 1C ; and

R 2 is C 2 -C 4 alkenyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —OR 2xa , or G 2A .

9. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A or G 1B -G 1C ; and

R 3 is G 3A , -G 3B -L 1 -G 3C , —OR 3a , or —N(R 3a )(R 3b ).

10. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A or -G 1B -G 1C ;

R 2 is C 2 -C 4 alkenyl, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, —OR 2xa , or G 2A ; and

R 3 is G 3A , -G 3B -L 1 -G 3C , —OR 3a , or —N(R 3a )(R 3b ).

11. The compound of claim 10 or a pharmaceutically acceptable salt thereof, wherein

G 1A is optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;

R 2 is C 1 -C 6 alkyl; and

G 3A is an optionally substituted 4-11 membered heterocycle.

12. The compound of claim 10 or a pharmaceutically acceptable salt thereof, wherein

G 1A is optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;

R 2 is —OR 2xa or G 2A ; and

R 2xa is G 2B .

13. The compound of claim 12 or a pharmaceutically acceptable salt thereof, wherein

R 2 is G 2A ; and

G 2A is optionally substituted C 3 -C 6 monocyclic cycloalkyl.

14. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A or -G 1B -G 1C ;

R 2 is C 1 -C 6 alkyl or G 2A ; and

R 3 is G 3A , -G 3B -L 1 -G 3C , or —OR 3a .

15. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A ;

G 1A is optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;

R 2 is C 1 -C 6 alkyl;

R 3 is G 3A ; and

G 3A is an optionally substituted 4-7 membered monocyclic heterocycle.

16. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A ;

G 1A is optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;

R 2 is G 2A ;

G 2A is optionally substituted C 3 -C 6 monocyclic cycloalkyl;

R 3 is G 3A ; and

G 3A is optionally substituted phenyl, optionally substituted 5-6 membered monocyclic heteroaryl, or optionally substituted 4-11 membered heterocycle.

17. The compound of claim 16 or a pharmaceutically acceptable salt thereof, wherein

G 3A is an optionally substituted 4-7 membered monocyclic heterocycle.

18. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A ;

G 1A is optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;

R 2 is C 1 -C 6 alkyl or G 2A ;

G 2A is optionally substituted C 3 -C 6 monocyclic cycloalkyl; and

R 3 is -G 3B -L 1 -G 3C .

19. The compound of claim 18 or a pharmaceutically acceptable salt thereof, wherein

L 1 is a bond, C 1 -C 3 alkylenyl, or (C 1 -C 3 alkylenyl) r -L 2 -(C 1 -C 3 alkylenyl) s ;

L 2 is O, N(R x ), or C(O); and

G 3B is optionally substituted phenyl, optionally substituted 5-6 membered monocyclic heteroaryl, or optionally substituted 4-7 membered monocyclic heterocycle.

20. The compound of claim 19 or a pharmaceutically acceptable salt thereof, wherein

L 2 is O or N(R x ); and

G 3B is an optionally substituted 4-7 membered monocyclic heterocycle.

21. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A ;

G 1A is optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;

R 2 is C 1 -C 6 alkyl or G 2A ;

G 2A is optionally substituted C 3 -C 6 monocyclic cycloalkyl;

R 3 is —OR 3a ; and

R 3a is G 3E , C 1 -C 6 haloalkyl, or C 1 -C 6 alkyl; wherein the C 1 -C 6 haloalkyl and the C 1 -C 6 alkyl are each substituted with one or two substituents independently selected from the group consisting of G 3E , —OR 3xa , —C(O)G 3D , —N(R 3xb ) 2 , and —S(O) 2 R 3xc .

22. The compound of claim 21 or a pharmaceutically acceptable salt thereof, wherein

R 3a is C 1 -C 6 haloalkyl or C 1 -C 6 alkyl; wherein the C 1 -C 6 haloalkyl and the C 1 -C 6 alkyl are each substituted with one G 3E .

23. The compound of claim 22 or a pharmaceutically acceptable salt thereof, wherein

G 3E is an optionally substituted 4-7 membered monocyclic heterocycle.

24. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is -G 1B -G 1C ;

R 2 is C 1 -C 6 alkyl or G 2A ; and

R 3 is G 3A , -G 3B -L 1 -G 3C , or —OR 3a .

25. The compound of claim 24 or a pharmaceutically acceptable salt thereof, wherein

R 3 is G 3A ; and

G 3A is optionally substituted phenyl, optionally substituted 5-6 membered monocyclic heteroaryl, or optionally substituted 4-11 membered heterocycle.

26. The compound of claim 24 or a pharmaceutically acceptable salt thereof, wherein

R 3 is G 3A ; and

G 3A is optionally substituted 4-7 membered monocyclic heterocycle.

27. The compound of claim 24 or a pharmaceutically acceptable salt thereof, wherein

R 3 is -G 3B -L 1 -G 3C ; and

G 3B is optionally substituted phenyl, optionally substituted 5-6 membered monocyclic heteroaryl, or optionally substituted 4-7 membered monocyclic heterocycle.

28. The compound of claim 24 or a pharmaceutically acceptable salt thereof, wherein

R 3 is -G 3B -L 1 -G 3C ;

L 1 is a bond, C 1 -C 3 alkylenyl, or (C 1 -C 3 alkylenyl) r -L 2 -(C 1 -C 3 alkylenyl) s ;

L 2 is O or N(R x ); and

G 3B is optionally substituted 4-7 membered monocyclic heterocycle.

29. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 3 is -G 3B -L 3 -G 3C -L 4 -G 3F or —(C 1 -C 6 alkylenyl)-G 3E .

30. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A or -G 1B -G 1C ;

R 2 is C 1 -C 6 alkyl or G 2A ; and

R 3 is -G 3B -L 3 -G 3C -L 4 -G 3F or —(C 1 -C 6 alkylenyl)-G 3E .

31. The compound of claim 30 or a pharmaceutically acceptable salt thereof, wherein

R 1 is G 1A ;

G 1A is optionally substituted phenyl or optionally substituted 5-6 membered monocyclic heteroaryl;

G 2A is optionally substituted C 3 -C 6 monocyclic cycloalkyl; and

L 4 is a bond, —(C 1 -C 6 alkylenyl), N(R 2x ), or C(O).

32. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclopentyl-4-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(2-cyanoethyl)-4-(4-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-phenyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-[5-(trifluoromethyl)-1H-pyrazol-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-[4-(piperidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(4-methylpiperazin-1-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,5-difluorophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-chlorophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-fluorophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-(3-methylphenyl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(1,1-dioxo-1λ 6 ,4-thiazinan-4-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[2-(morpholin-4-yl)pyrimidin-5-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(ethoxycarbonyl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-bromophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(hydroxymethyl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methoxyphenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-(oxan-4-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-phenyl-3-(propan-2-yl)-4-[4-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-[4-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-chloro-4-(morpholin-4-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-fluoropyrrolidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-acetylpiperazin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,5-dimethylphenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-[3-(morpholin-4-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-methoxy-4-(morpholin-4-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclopropyl-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-[3-(trifluoromethoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,4-difluorophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(methanesulfonyl)phenyl]-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-(1-methylpiperidin-4-yl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-tert-butyl-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(2-chloropyridin-4-yl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3,5-dimethyl-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,5-dichlorophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-(3-sulfamoylphenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-(1-methyl-1H-pyrazol-4-yl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-[1-(tert-butoxycarbonyl)azetidin-3-yl]-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-phenyl-3-(prop-1-en-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-cyanophenyl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(2-methoxypyridin-4-yl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-fluoro-5-methoxyphenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(methylcarbamoyl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(1-hydroxy-2-methylpropan-2-yl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(2-fluoropyridin-4-yl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)phenyl]-1-(2-oxo-1,2-dihydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-carbamoylphenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-tert-butylpiperazin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(6-methoxypyridin-3-yl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[2-(dimethylamino)pyrimidin-5-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(2-hydroxypropan-2-yl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-carbamoyl-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-methyl-4-[2-(morpholin-4-yl)pyrimidin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[3-bromo-4-(morpholin-4-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclopentyl-4-[2-(dimethylamino)pyrimidin-5-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-(oxan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclopentyl-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[4-(methoxycarbonyl)piperazin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(1-acetylpiperidin-4-yl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[3-(dimethylamino)azetidin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3,3-dimethylazetidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-methyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[2-(dimethylamino)pyrimidin-5-yl]-3-methyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-[1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclopentyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(1-acetylazetidin-3-yl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(morpholin-4-yl)pyrimidin-5-yl]-1-phenyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[2-(morpholin-4-yl)pyrimidin-5-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-{4-[4-(3,3,3-trifluoropropyl)piperazin-1-yl]phenyl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclopentyl-4-[6-(dimethylamino)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-[2-(morpholin-4-yl)pyrimidin-5-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-[6-(morpholin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-[1-(methoxycarbonyl)azetidin-3-yl]-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-[(dimethylamino)methyl]-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(dimethylamino)pyrimidin-5-yl]-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(dimethylamino)pyridin-3-yl]-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-3-methyl-4-[2-(morpholin-4-yl)pyrimidin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-tert-butyl-1-cyclopentyl-4-[2-(dimethylamino)pyrimidin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(1-hydroxy-2-methylpropan-2-yl)-4-[6-(morpholin-4-yl)pyridin-3-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(dimethylamino)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[1-(cyanomethyl)piperidin-4-yl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(cyclobutylamino)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3,3-difluoroazetidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[4-(cyanomethyl)piperazin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(dimethylamino)pyridin-3-yl]-3-methyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-tert-butyl-1-cyclopentyl-4-[2-(morpholin-4-yl)pyrimidin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-fluorophenyl)-3-methyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-[1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-4-[6-(morpholin-4-yl)pyridin-3-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(2,4-difluorophenyl)-3-methyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(2,4-difluorophenyl)-3-methyl-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclopentyl-3-methyl-4-[6-(morpholin-4-yl)pyridin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4,4-difluoropiperidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{4-[methyl(oxan-4-yl)amino]phenyl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3,3-difluoropyrrolidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{4-[(oxetan-3-yl)amino]phenyl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(3-methyloxetan-3-yl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(2,6-dimethylmorpholin-4-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[cyclobutyl(methyl)amino]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(morpholin-4-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(2,2-dimethylmorpholin-4-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-(oxolan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(morpholin-4-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(methoxymethyl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-(piperidin-1-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-hydroxyazetidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-fluoroazetidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]phenyl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3,6-dihydro-2H-pyran-4-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(1-methylcyclopropyl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-tert-butyl-1-cyclohexyl-4-[4-(dimethylamino)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-acetylpiperazin-1-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[2-(hydroxymethyl)morpholin-4-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(azetidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(cyanomethyl)piperazin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-hydroxypiperidin-1-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(1-acetylpiperidin-4-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[1-(cyanomethyl)piperidin-4-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{4-[methyl(oxetan-3-yl)amino]phenyl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[1-(cyanomethyl)pyrrolidin-3-yl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[1-(methoxycarbonyl)pyrrolidin-3-yl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-methoxypiperidin-1-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-hydroxypiperidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{4-[(oxan-4-yl)amino]phenyl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methanesulfonyl)piperazin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-tert-butyl-1-cyclohexyl-4-[2-(dimethylamino)pyrimidin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-[1-(cyanomethyl)azetidin-3-yl]-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-tert-butyl-1-cyclohexyl-4-[2-(morpholin-4-yl)pyrimidin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(2-oxopiperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(azetidin-1-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(cyclohexylmethoxy)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-hydroxypyrrolidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(2-oxa-7-azaspiro[3.5]nonan-7-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(3S)-3-cyanopyrrolidin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-acetamidopyrrolidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-(piperidine-1-carbonyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4,4-difluorocyclohexyl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(3,3-dimethylazetidin-1-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1-[1-(2,2,2-trifluoroethyl)piperidin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-4-(piperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[(1R,3R)-3-(benzyloxy)cyclohexyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(3-methoxyazetidin-1-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(3-fluoropyrrolidin-1-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[2-(dimethylamino)pyrimidin-5-yl]-3-[1-(methoxycarbonyl)azetidin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(3-fluoroazetidin-1-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-acetamidophenyl)-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-{3-[(2-methoxyethyl)(methyl)amino]phenyl}-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-3-(propan-2-yl)-4-(pyrrolidin-1-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-fluoroazetidin-1-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-1-[3-(dimethylamino)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-[3-(dimethylamino)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(3,3-difluoropyrrolidin-1-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{4-[(2-methoxyethyl)(methyl)amino]phenyl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-3-(oxolan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(2-methoxyethyl)(methyl)amino]phenyl}-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-methoxypiperidin-1-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-cyanopiperidin-1-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-methoxypiperidin-1-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-cyclopropyl-4-[6-(dimethylamino)pyridin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

rac-1-[(1R,3R)-3-hydroxycyclohexyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

rac-1-[(1R,3S)-3-hydroxycyclohexyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(2,6-dimethylmorpholin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(2,2-dimethylmorpholin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-hydroxypiperidin-1-yl)phenyl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-[3-(dimethylamino)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-[2-(morpholin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-4-(2-oxa-7-azaspiro[3.5]nonan-7-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyano-4-methylpiperidin-1-yl)pyridin-3-yl]-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[(1R,3S)-3-methoxycyclohexyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-{4-[methyl(oxan-4-yl)amino]phenyl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[methyl(oxan-4-yl)amino]phenyl}-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(2-methoxyethyl)(methyl)amino]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4,4-difluoropiperidin-1-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-[5-(morpholin-4-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-methoxyazetidin-1-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(hydroxymethyl)piperidin-1-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[(1R,3R)-3-methoxycyclohexyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-3-(propan-2-yl)-4-[3-(trifluoromethyl)pyrrolidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-cyanopyrrolidin-1-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-3-cyclobutyl-1-cyclohexyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-cyclobutyl-1-cyclohexyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(3-fluoropiperidin-1-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[6-(3-methoxypyrrolidin-1-yl)pyridin-3-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(3-hydroxyazetidin-1-yl)phenyl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[5-(cyanomethyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methoxymethyl)piperidin-1-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(2-methoxyethyl)piperidin-1-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-chloropyridin-2-yl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{2-[(2-methoxyethyl)(methyl)amino]pyrimidin-5-yl}-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-1-[3-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[4-(cyanomethyl)piperazin-1-yl]phenyl}-1-(3-methoxyphenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(5-acetylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[1-(tert-butoxycarbonyl)octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{2-[(2-methoxyethyl)(methyl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(2-methoxyethyl)(methyl)amino]phenyl}-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(azetidin-1-yl)phenyl]-4-{6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(azetidin-1-yl)phenyl]-4-{4-[methyl(oxan-4-yl)amino]phenyl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-[4-(morpholin-4-yl)pyridin-2-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-fluorophenyl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,4-difluorophenyl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-[6-(morpholin-4-yl)pyridin-2-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,5-difluorophenyl)-4-{4-[methyl(oxan-4-yl)amino]phenyl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,5-difluorophenyl)-4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-3-cyclobutyl-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-cyclobutyl-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[methyl(oxan-4-yl)amino]phenyl}-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[methyl(oxan-4-yl)amino]phenyl}-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{6-[(2-methoxyethyl)(methyl)amino]pyridin-3-yl}-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{4-[methyl(oxan-4-yl)amino]phenyl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(1-acetyloctahydro-5H-pyrrolo[3,2-c]pyridin-5-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[1-(cyanomethyl)octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methanesulfonyl)piperidin-1-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-4-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-3-(propan-2-yl)-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(propan-2-yl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-3-(propan-2-yl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-4-(8-oxa-2-azaspiro[4.5]decan-2-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-cyanopiperidin-1-yl)-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(4-methoxypiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(piperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[4-(hydroxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[6-(dimethylamino)pyridin-2-yl]-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,5-difluorophenyl)-4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-3-(propan-2-yl)-1-[3-(trifluoromethoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-3-(propan-2-yl)-4-[3-(trifluoromethyl)pyrrolidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(1,1-difluoro-5-azaspiro[2.4]heptan-5-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[3-(methanesulfonyl)pyrrolidin-1-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(2-azaspiro[3.3]heptan-2-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-methylphenyl)-4-(5-oxa-2-azaspiro[3.5]nonan-2-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{6-[bis(2-methoxyethyl)amino]pyridin-3-yl}-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{6-[methyl(oxolan-3-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-1-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,4-difluorophenyl)-4-{4-[methyl(oxan-4-yl)amino]phenyl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-(3,4-difluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-1-(3,5-difluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-fluorophenyl)-4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-fluorophenyl)-4-{4-[methyl(oxan-4-yl)amino]phenyl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-(3-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-1-(3-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{6-[methyl(oxan-4-yl)amino]pyridin-3-yl}-3-(propan-2-yl)-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(4-methyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[3-(methoxymethyl)-3-methylazetidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(3-oxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methoxymethyl)piperidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-acetamidopiperidin-1-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[3-(methoxymethyl)azetidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3R)-3-methoxypyrrolidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3S)-3-methoxypyrrolidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-fluoropiperidin-1-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3R)-3-fluoropyrrolidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3,3-difluoropyrrolidin-1-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3S)-3-fluoropyrrolidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(3-oxotetrahydro-3H-[1,3]oxazolo[3,4-a]pyrazin-7(1H)-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[3-(morpholin-4-yl)azetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(methanesulfonyl)amino]piperidin-1-yl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-azabicyclo[3.1.0]hexan-3-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(6-oxa-2-azaspiro[3.4]octan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(2-azaspiro[3.4]octan-2-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(2-azaspiro[3.5]nonan-2-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(5-azaspiro[2.5]octan-5-yl)-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(1-oxa-7-azaspiro[4.4]nonan-7-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(5-oxa-2-azaspiro[3.5]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(6-oxo-2,7-diazaspiro[4.4]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(1S)-2-(dimethylamino)-1-fluoroethyl]piperidin-1-yl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-(1,4-oxazepan-4-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3-fluorophenyl)-4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(3,5-difluorophenyl)-4-{2-[methyl(oxan-4-yl)amino]pyrimidin-5-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(2-methoxyethoxy)piperidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(dimethylcarbamoyl)piperidin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methanesulfonyl)-1,4-diazepan-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-methoxypropyl)piperazin-1-yl]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholine-4-carbonyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[2-(dimethylamino)-2-oxoethyl]piperazin-1-yl}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(4-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-(2,4-difluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-(2,4-difluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-1-(2,4-difluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-(piperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-cyanopiperidin-1-yl)-1-[3-(dimethylamino)phenyl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-(4-methoxypiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-[4-(hydroxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(1-methylcyclobutyl)-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{[cis-3-(1,1-dioxo-1λ 6 ,4-thiazinan-4-yl)cyclobutyl]oxy}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(1,1-dioxo-1λ 6 ,4-thiazinan-4-yl)ethoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(2S)-2-fluoro-2-(oxan-4-yl)ethoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(2R)-2-fluoro-2-(oxan-4-yl)ethoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{[(3S)-1-methylpyrrolidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{[(3R)-1-methylpyrrolidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[(1-methylpiperidin-4-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{[cis-3-(dimethylamino)cyclobutyl]oxy}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[(oxetan-3-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-[2-(pyrrolidin-1-yl)ethoxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-{[(3R)-1-methylpiperidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[(2-oxaspiro[3.3]heptan-6-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-{[trans-3-(piperidin-1-yl)cyclobutyl]oxy}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-1-phenyl-4-{[cis-3-(piperidin-1-yl)cyclobutyl]oxy}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(3,3-difluorocyclobutyl)ethoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(fluoromethyl)piperidin-1-yl]-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3-fluorophenyl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3,4-difluorophenyl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(1-methyl-1H-pyrrol-3-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(1,3-dimethyl-1H-pyrazol-4-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3,5-difluorophenyl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)phenyl]-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3-fluoro-4-methylphenyl)-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)phenyl]-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-[4-(dimethylamino)phenyl]-4-[4-(morpholin-4-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-methoxypiperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-methyl-2-oxo-1-oxa-3,8-diazaspiro[4.5]decan-8-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-azaspiro[5.5]undecan-3-yl)-1-(3-methylphenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-(propan-2-yl)-4-[1-(propan-2-yl)-1H-pyrazol-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(1-methyl-1H-pyrrol-2-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-(propan-2-yl)-4-(1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(1-oxo-2,3-dihydro-1H-isoindol-5-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-(oxan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(3-cyanopiperidin-1-yl)pyrimidin-5-yl]-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-oxo-2-(pyrrolidin-1-yl)ethoxy]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-[4-(methoxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(propan-2-yl)-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(1-methyl-1H-pyrazol-5-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[(propan-2-yl)oxy]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(methoxymethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(2-{[1-(tert-butoxycarbonyl)piperidin-4-yl](methyl)amino}pyrimidin-5-yl)-1-cyclohexyl-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[(3-methyloxetan-3-yl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(4-methoxycyclohexyl)oxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-fluoro-2-(oxan-4-yl)ethoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3-fluoro-1-methylpyrrolidin-3-yl)methoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(2S)-2-fluoro-2-(1-methylpiperidin-4-yl)ethoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(2R)-2-fluoro-2-(1-methylpiperidin-4-yl)ethoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[3-fluoro-1-(oxetan-3-yl)piperidin-3-yl]methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3,3-difluorocyclopentyl)methoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-methyl-4-[2-oxo-2-(piperidin-1-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[1-(methanesulfonyl)cyclobutyl]methoxy-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{2-[cyclopropyl(2-methylpropyl)amino]ethoxy}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3,3-difluoro-1-methylcyclobutyl)methoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{[1-(fluoromethyl)cyclopropyl]methoxy}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{[1-(2-methoxyethyl)cyclopropyl]methoxy}-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(2,2-difluorocyclopentyl)methoxy]-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(morpholin-4-yl)phenyl]-1-phenyl-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(methoxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyanopiperidin-1-yl)phenyl]-3-(propan-2-yl)-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(4-methoxypiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(hydroxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-butoxypiperidin-1-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(2-methylpropoxy)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(4-methoxy-4-methylpiperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(1-oxa-7-azaspiro[3.5]nonan-7-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[3-(difluoromethyl)piperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(1-oxa-8-azaspiro[4.5]decan-8-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-(propan-2-yl)-4-(2,2,6,6-tetramethyl-3,6-dihydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2-methoxyethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(2-azaspiro[3.4]octan-2-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(methoxymethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-azabicyclo[3.1.0]hexan-3-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(cyclohexylmethoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-(piperidin-1-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(2-azaspiro[3.5]nonan-2-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-cyanopiperidin-1-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(methanesulfonyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-methoxypiperidin-1-yl)-3-(propan-2-yl)-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-cyclobutyl-1-[2-(pyrrolidin-1-yl)pyridin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(oxan-4-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2S)-2-fluoro-2-(oxan-4-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-cyclobutyl-1-[2-(morpholin-4-yl)pyridin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(oxan-4-yl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(methoxymethyl)azetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(5-azaspiro[2.5]octan-5-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(3,3-difluorocyclobutyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(cis-3-methoxycyclobutyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2-methoxyethyl)(methyl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1,1-difluoro-5-azaspiro[2.4]heptan-5-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(5-oxa-2-azaspiro[3.5]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(2-azaspiro[3.3]heptan-2-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(benzyloxy)methyl]piperidin-1-yl}-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(cis-4-methoxycyclohexyl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(trans-4-methoxycyclohexyl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(3,3-dimethylcyclobutyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[4-(methoxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(cis-3-fluorocyclobutyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(trans-3-fluorocyclobutyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2R)-2-fluoro-2-(oxan-4-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3,3-difluorocyclopentyl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(1,1-dioxo-1λ 6 ,4-thiazinan-4-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-[2-(morpholin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(2-methoxypropan-2-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(cis-3-tert-butoxycyclobutyl)(methyl)amino]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-methylazetidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3,3-difluoropyrrolidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[3-(trifluoromethyl)pyrrolidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[4-(pyrrolidin-1-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-fluoropiperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R,4R)-3,4-dihydroxypyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3S,4S)-3,4-dihydroxypyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(dimethylamino)ethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(diethylamino)ethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(cyclopropylmethyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-cyclobutylpiperazin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-fluoro-3-methylazetidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(8-azaspiro[4.5]decan-8-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3,3-difluoro-1-oxa-8-azaspiro[4.5]decan-8-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1′-methyl[4,4′-bipiperidin]-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(1R)-2-(dimethylamino)-1-fluoroethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(1S)-2-(dimethylamino)-1-fluoroethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(1S)-1-fluoro-2-hydroxyethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(1R)-1-fluoro-2-hydroxyethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-fluoro-4-[(2-methoxyethoxy)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(ethoxymethyl)-3-fluoropiperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(ethoxymethyl)-4-fluoropiperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{3-fluoro-3-[(2-methoxyethoxy)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-fluoro-4-(methoxymethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R,4R)-3-fluoro-4-hydroxypiperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R,4R)-4-fluoro-3-hydroxypiperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[3-(piperidin-1-yl)azetidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-(methanesulfonyl)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-methoxypiperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-oxo-1-(propan-2-yl)-1,3,8-triazaspiro[4.5]decan-8-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(3-hydroxypropyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(azepan-1-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(7R,8aS)-7-hydroxyhexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3,3-difluoro-1-methylcyclobutyl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(3,3-difluorocyclobutyl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{2-[(oxetan-3-yl)(propan-2-yl)amino]ethoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(1-acetyl-4-fluoropiperidin-4-yl)methoxy]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(2S)-oxolan-2-yl]methoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(3-methoxyazetidin-1-yl)-2-oxoethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2R)-2-fluoro-2-(1-methylpiperidin-4-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{2-[(oxetan-3-yl)oxy]ethoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{2-[1-(2-methoxyethyl)cyclopropyl]ethoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[1-(2-methoxyethyl)cyclopropyl]methoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2,2-difluorocyclopentyl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(morpholin-4-yl)propoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(1,3-dioxan-2-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-fluoropropoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3-methyloxetan-3-yl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(1,3-dimethoxypropan-2-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[cis-3-(dimethylamino)cyclobutyl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2-methyl-1,3-dioxan-5-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3S)-1-methylpiperidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2-oxaspiro[3.3]heptan-6-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3R)-1-methylpiperidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-[(1-acetylazetidin-3-yl)oxy]-4-[4-(morpholin-4-yl)phenyl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(1-methoxyethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[4-(1,1,1-trifluoro-2-methoxypropan-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(diethylcarbamoyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-hydroxypiperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(1,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)ethyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(4aS,7aR)-4-methyl-3-oxohexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-oxopiperazin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(5 aS,8aS)-2-oxooctahydropyrrolo[3,4-b]azepin-7(1H)-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2R)-4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-fluoro-3-(methoxymethyl)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R,4S)-3-fluoro-4-hydroxypiperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(ethoxymethyl)-3-fluoropyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(hydroxymethyl)-3-methylazetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3S)-3-methoxypyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(2,2-difluoroethoxy)azetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2R,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(7S,8aS)-7-fluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(4aS,7aS)-4-methyl-3-oxohexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-fluoro-4-(hydroxymethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1-oxa-7-azaspiro[4.4]nonan-7-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(methanesulfonyl)amino]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(1-fluoro-2-hydroxyethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(methoxymethyl)-3-methylazetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-methoxypyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(methanesulfonyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{6-[bis(2-methoxyethyl)amino]pyridin-3-yl}-1-[2-(morpholin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methoxymethyl)piperidin-1-yl]-1-[2-(morpholin-4-yl)pyridin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-methoxy-4-(methoxymethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3S)-3-fluoropyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3,3-difluoroazetidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(2-oxo-1,3-oxazolidin-3-yl)azetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-ethyl-3-fluoroazetidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(hydroxymethyl)morpholin-4-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{3-fluoro-3-[(2-methoxyethoxy)methyl]pyrrolidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(cis-3-hydroxycyclobutyl)(methyl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(6-oxa-2-azaspiro[3.4]octan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R,4S)-4-fluoro-3-hydroxypiperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-hydroxy-3-methylazetidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(6-oxo-2,7-diazaspiro[4.4]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(2S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(ethoxycarbonyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(cyclohexylamino)-2-oxoethyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-fluoropyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-methoxyazetidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(2-hydroxy-7-azaspiro[3.5]nonan-7-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-(hydroxymethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1,4-oxazepan-4-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-hydroxy-4-(2-hydroxyethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(cyclobutylmethyl)-4-[4-(methoxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methoxymethyl)piperidin-1-yl]-1-(2-methylpropyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

rac-4-[(3aR,7aS)-1-(tert-butoxycarbonyl)octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-phenyl-3-[(pyrrolidin-3-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-(trans-3-methylcyclobutyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-{[1-(tert-butoxycarbonyl)pyrrolidin-3-yl]oxy}-4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-{[1-(tert-butoxycarbonyl)piperidin-4-yl]oxy}-4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{methyl[(oxan-4-yl)methyl]amino}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[4-(2-propoxyethyl)piperazin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{2-[(piperidin-1-yl)methyl]morpholin-4-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[(pyrrolidin-1-yl)methyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[3-(morpholin-4-yl)propyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(dimethylamino)-2-oxoethyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(2-cyanoethyl)piperazin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{2-[(dimethylamino)methyl]morpholin-4-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-methylpiperazin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(methyl {[1-(2-methylpropyl)piperidin-4-yl]methyl}amino)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{methyl[2-(morpholin-4-yl)ethyl]amino}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2-ethoxyethyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(methylamino)-2-oxoethyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(morpholin-4-yl)acetyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2-methoxyethyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(oxolan-2-yl)methyl]-1,4-diazepan-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{3-[(propan-2-yl)oxy]azetidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(morpholin-4-yl)ethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-([1,4′-bipiperidin]-1′-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-(morpholin-4-yl)pyrrolidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(4,4-difluorocyclohexyl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(oxan-4-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(1S,2S)-2-methoxycyclohexyl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3-ethyloxetan-3-yl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3R)-oxolan-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3S)-oxolan-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-methoxy-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(cyclobutyloxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(2-methoxyethoxy)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3aR,7aS)-1-acetyloctahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3aS,7aR)-1-acetyloctahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(methoxymethyl)piperidin-1-yl]-1-[2-(morpholin-4-yl)pyrimidin-4-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(oxan-4-yl)methyl]amino}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-[(oxolan-3-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[6-(4-cyanopiperidin-1-yl)pyridin-3-yl]-3-[(oxetan-3-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{methyl[(1-methylpiperidin-3-yl)methyl]amino}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4,4-difluoropiperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-fluoro-3-(methoxymethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[2-(trifluoromethyl)morpholin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(cyclopentyloxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{[cis-3-(azetidin-1-yl)cyclobutyl]oxy}-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(1-cyclohexylazetidin-3-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3,3-difluorocyclobutyl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(1-methylazetidin-3-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[3-(dimethylamino)phenyl]-4-[(oxan-4-yl)methoxy]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[(oxan-4-yl)methoxy]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[2-(oxan-4-yl)ethoxy]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2-methoxypropan-2-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[3-(dimethylamino)propoxy]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[3-(morpholin-4-yl)propoxy]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[(3-methyloxetan-3-yl)methoxy]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[(oxolan-2-yl)methoxy]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

rac-3-cyclobutyl-1-phenyl-4-[(3aR,7aS)-1-{[(propan-2-yl)oxy]carbonyl}octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(dimethylamino)butoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(1-acetylpiperidin-4-yl)oxy]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-(2,2,2-trifluoroethoxy)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{2-[2-(dimethylamino)ethoxy]ethoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(2S)-1-(dimethylamino)propan-2-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(4,4-difluorocyclohexyl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(2R)-5-oxopyrrolidin-2-yl]methoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3S)-6-oxopiperidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(5-ethyl-1,3-dioxan-5-yl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3-endo)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]oxy}-1-phenyl-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(5-methyl-1,3-dioxan-5-yl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(diethylamino)propoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{2-[cyclohexyl(oxetan-3-yl)amino]ethoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[4-fluoro-1-(methanesulfonyl)piperidin-4-yl]methoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[4-(methanesulfonyl)oxan-4-yl]methoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[2-(pyrrolidin-1-yl)ethoxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(methanesulfonyl)-2-methylpropoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(1-methylcyclopropyl)methoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(1-methylcyclopropyl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[1-(methanesulfonyl)cyclobutyl]methoxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(2-cyclohexylethoxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(4-methylpiperazin-1-yl)propoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(dimethylamino)propoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(dimethylamino)-2,2-dimethylpropoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(dimethylamino)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{[1,3-bis(dimethylamino)propan-2-yl]oxy}-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[2-(piperidin-1-yl)ethoxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(2-oxoimidazolidin-1-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{[1,3-bis(morpholin-4-yl)propan-2-yl]oxy}-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[3-(piperidin-1-yl)propoxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[2-(azepan-1-yl)ethoxy]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[2-(4-methyl-1,4-diazepan-1-yl)ethoxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(2s,4r)-5-methyl-5-azaspiro[3.4]octan-2-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(1-{3-[(diethylamino)methyl]oxetan-3-yl}azetidin-3-yl)oxy]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{[1-(propan-2-yl)piperidin-4-yl]oxy}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(cycloheptyloxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(cyclooctyloxy)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3R)-1-methylpyrrolidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{[(3S)-1-methylpyrrolidin-3-yl]oxy}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3,3-difluoro-1-methylcyclobutyl)methoxy]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[3-(piperidin-1-yl)propoxy]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(1,3-dimethoxypropan-2-yl)oxy]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-({[(2S)-oxolan-2-yl]methyl}amino)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[4-(methoxymethyl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[(oxan-4-yl)methoxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2-hydroxypropan-2-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(dimethylamino)piperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(1′-methyl[4,4′-bipiperidin]-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(1-acetylpiperidin-4-yl)methoxy]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{[1-(methoxycarbonyl)piperidin-4-yl]methoxy}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[(oxane-4-carbonyl)amino]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(cyanomethyl)-4-hydroxypiperidin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(ethoxymethyl)-4-fluoropiperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-fluoro-4-[(2-methoxyethoxy)methyl]piperidin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3R,4R)-3-fluoro-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-fluoro-4-(methoxymethyl)piperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{3-fluoro-3-[(2-methoxyethoxy)methyl]piperidin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3S)-3-{[(tert-butoxycarbonyl)amino]methyl}pyrrolidin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3R)-3-{[(tert-butoxycarbonyl)amino]methyl}pyrrolidin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1,1-dioxo-1λ 6 ,4-thiazinan-4-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3R)-3-{[(tert-butoxycarbonyl)(methyl)amino]methyl}pyrrolidin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3S)-3-{[(tert-butoxycarbonyl)(methyl)amino]methyl}pyrrolidin-1-yl]-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{(3S)-3-[(methylamino)methyl]pyrrolidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(2,6-dimethylpyridin-4-yl)-4-[4-(methoxymethyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(methoxymethyl)piperidin-1-yl]-1-(2-methoxypyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[3-(pyrrolidin-1-yl)azetidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(oxolan-2-yl)methyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(1-methoxypropan-2-yl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[1-(morpholin-4-yl)ethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(1,3-dioxolan-2-yl)methyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2-methoxyethoxy)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[(piperidin-1-yl)methyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(4-methylpiperidin-1-yl)ethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2,6-dimethylmorpholin-4-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(diethylamino)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[{3-[cyclohexyl(methyl)amino]propyl}(methyl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3aR,6aS)-5-(2-methylpropyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-([1,4′-bipiperidin]-1′-yl)-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[4-(2-methoxyethyl)piperazin-1-yl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(4-methylpiperazin-1-yl)ethyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(ethoxyacetyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-(2-oxopyrrolidin-1-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4′-methyl[1,4′-bipiperidin]-1′-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(2-methylpropoxy)carbonyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-methyl-1,4-diazepan-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-acetylpiperazin-1-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(3-methoxypropyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-cyclopentyl-1,4-diazepan-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(3R)-3-hydroxypiperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-(4-propylpiperazin-1-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(dimethylcarbamoyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(morpholin-4-yl)azetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-butyl-1,4-diazepan-1-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(morpholine-4-carbonyl)[1,4′-bipiperidin]-1′-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-(4-propyl-1,4-diazepan-1-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[(3R)-3-(piperidin-1-yl)pyrrolidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(7-cyano-5-oxa-2-azaspiro[3.4]octan-2-yl)-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[3-(4-methyl-1,4-diazepan-1-yl)-3-oxopropyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(dimethylcarbamoyl)-4-(2-oxopyrrolidin-1-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(cyclohexylmethyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2-hydroxyethyl)piperazin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[3-(4-methylmorpholin-2-yl)azetidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-{4-[methyl(oxetan-3-yl)amino]piperidin-1-yl}azetidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{3-[4-(morpholin-4-yl)piperidin-1-yl]azetidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[1-(2-ethoxyethyl)piperidin-4-yl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[1-(2-hydroxypropyl)piperidin-4-yl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[3-(dimethylamino)propyl]piperazin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[4-(2-ethoxyethyl)piperazin-1-yl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[2-(piperidin-1-yl)ethoxy]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[3-(diethylamino)propyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[3-(piperidin-1-yl)propyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[3-(pyrrolidin-1-yl)propyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[ethyl(oxetan-3-yl)amino]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[methyl(oxetan-3-yl)amino]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[1′-(oxetan-3-yl)[4,4′-bipiperidin]-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(dimethylamino)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(4-methylpiperazine-1-carbonyl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[3-(4-methylmorpholin-2-yl)azetidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[1-(2-ethoxyethyl)piperidin-4-yl]piperazin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[1-(2-hydroxypropyl)piperidin-4-yl]piperazin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(1-cyclopropylpiperidin-4-yl)piperazin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[4-(2-ethoxyethyl)piperazin-1-yl]piperidin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[4-(2-methoxyethyl)piperazin-1-yl]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[3-(diethylamino)propyl]piperidin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[3-(piperidin-1-yl)propyl]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-(propan-2-yl)-4-{4-[3-(pyrrolidin-1-yl)propyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[ethyl(oxetan-3-yl)amino]piperidin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[methyl(oxetan-3-yl)amino]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[1′-(oxetan-3-yl)[4,4′-bipiperidin]-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(4-methylpiperazine-1-carbonyl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(3-{4-[methyl(oxetan-3-yl)amino]piperidin-1-yl}azetidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{3-[4-(morpholin-4-yl)piperidin-1-yl]azetidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[3-(dimethylamino)propyl]piperazin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-methyl-4-(4-methylpiperazin-1-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[2-(piperidin-1-yl)ethoxy]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-5-methyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[4-(4-methylpiperazine-1-carbonyl)phenyl]-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[3-(morpholin-4-yl)azetidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-(propan-2-yl)-4-(4-propyl-1,4-diazepan-1-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-cyclobutyl-1,4-diazepan-1-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-butyl-1,4-diazepan-1-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(4-methyl-1,4-diazepan-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-acetylpiperazin-1-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-ethylpiperazin-1-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(2-hydroxyethyl)piperazin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(dimethylcarbamoyl)piperazin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(ethoxyacetyl)piperazin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(3-methoxypropyl)piperazin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-(propan-2-yl)-4-(4-propylpiperazin-1-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[3-(4-methyl-1,4-diazepan-1-yl)-3-oxopropyl]piperazin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(cyclohexylmethyl)piperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[(3R)-3-hydroxypiperidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(4′-methyl[1,4′-bipiperidin]-1′-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[2-(4-methylpiperazin-1-yl)ethyl]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[(3R)-3-(piperidin-1-yl)pyrrolidin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(diethylamino)piperidin-1-yl]-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-tert-butylpiperazin-1-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-(propan-2-yl)-4-{4-[1-(pyrrolidin-1-yl)ethyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[(piperidin-1-yl)methyl]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[(1-methylpiperidin-3-yl)methyl]piperazin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[(oxolan-2-yl)methyl]piperazin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(1-methoxypropan-2-yl)piperazin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-(propan-2-yl)-4-[3-(pyrrolidin-1-yl)azetidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-(propan-2-yl)-4-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[(3aR,6aS)-5-(2-methylpropyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-ethyl-1,4-diazepan-1-yl)-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(4-hydroxy-4-{[methyl(propan-2-yl)amino]methyl}piperidin-1-yl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[methyl(propan-2-yl)amino]piperidin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[2-(diethylamino)ethyl]piperazin-1-yl}-1-(4-fluorophenyl)-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[(3R)-3-(methoxymethyl)pyrrolidin-1-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[(3R)-3-methoxypyrrolidin-1-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[(3S)-3-(methoxymethyl)pyrrolidin-1-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[1-(morpholin-4-yl)ethyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-{4-[(morpholin-4-yl)methyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-{4-[2-(morpholin-4-yl)ethyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-(cyclobutyloxy)-1-cyclohexyl-4-{4-[(morpholin-4-yl)methyl]phenyl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-[4-(pyridin-4-yl)piperazin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[2-(morpholin-4-yl)ethyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-(propan-2-yl)-4-{4-[(pyrrolidin-1-yl)methyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-{4-[1-(pyrrolidin-1-yl)ethyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-oxo-2,8-diazaspiro[4.5]decan-2-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-{4-[(2-methylpropoxy)carbonyl]piperazin-1-yl}-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(2-methoxypyridin-4-yl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(methoxymethyl)piperidin-1-yl]-1-[2-(oxan-4-yl)pyridin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-phenyl-4-[4-(propan-2-yl)piperazin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-[2-(oxan-4-yl)pyridin-4-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3-methylphenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[(morpholin-4-yl)methyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3-methoxyphenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-[4-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluoro-3-methylphenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3-fluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-[3-(trifluoromethyl)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(3-fluoroazetidin-1-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(3,3-difluoropyrrolidin-1-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(3-methoxyazetidin-1-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(3,3-difluoropiperidin-1-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[3-(methoxymethyl)azetidin-1-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(1,4-oxazepan-4-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[3-(2,2-difluoroethoxy)azetidin-1-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(6-oxa-2-azaspiro[3.5]nonan-2-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(6-oxa-2-azaspiro[3.4]octan-2-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-{[(7S,8aS)-7-fluorohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]methyl}piperidin-1-yl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(4-formyl-1,4-diazepan-1-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(2-oxa-7-azaspiro[3.5]nonan-7-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(4-methoxypiperidin-1-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(2-oxa-6-azaspiro[3.4]octan-6-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(4-formylpiperazin-1-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-{4-[(3-azabicyclo[3.1.0]hexan-3-yl)methyl]piperidin-1-yl}-3-cyclobutyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-{4-[(5-methyl-6-oxo-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)methyl]piperidin-1-yl}-1-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[4-(3-fluoropyrrolidin-1-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-cyanoazetidin-1-yl)piperidin-1-yl]-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[4-(3-methoxypyrrolidin-1-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4-fluoro[1,4′-bipiperidin]-1′-yl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(4,4-difluoro[1,4′-bipiperidin]-1′-yl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(2-cyanomorpholin-4-yl)piperidin-1-yl]-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[4-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[2-(methoxymethyl)morpholin-4-yl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[methyl(oxan-4-yl)amino]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-{2-[(propan-2-yl)oxy]pyridin-4-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-[2-(benzyloxy)pyridin-4-yl]-3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[(morpholin-4-yl)methyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[(4-methylpiperazin-1-yl)methyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{[4-(methoxymethyl)piperidin-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-cyano[1,4′-bipiperidin]-1′-yl)-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{4-[4-(dimethylamino)piperidine-1-carbonyl]phenyl}-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[3-(pyrrolidin-1-yl)-1-oxa-8-azaspiro[4.5]decan-8-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-3-[(propan-2-yl)oxy]-4-{4-[4-(propan-2-yl)piperazin-1-yl]phenyl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-[4-(2-methylpyridin-4-yl)piperazin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-{6-[4-(propan-2-yl)piperazin-1-yl]pyridin-3-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-{4-[1-(morpholin-4-yl)ethyl]phenyl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-{4-[4-(propan-2-yl)piperazin-1-yl]phenyl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-[6-(4-cyclopropylpiperazin-1-yl)pyridin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[3-(trifluoromethyl)pyrrolidin-1-yl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[4-(3-cyanopyrrolidin-1-yl)piperidin-1-yl]-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(3-cyano[1,4′-bipiperidin]-1′-yl)-3-cyclobutyl-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(3-fluoro[1,4′-bipiperidin]-1′-yl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[4-(3-methoxyazetidin-1-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[3-(trifluoromethyl)[1,4′-bipiperidin]-1′-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-(3-methoxy[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(2,2-dimethylmorpholin-4-yl)piperidin-1-yl]-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-{6-[4-(2-methoxyethyl)piperazin-1-yl]pyridin-3-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[4-(propan-2-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-cyclohexyl-4-{4-[4-(propan-2-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3S)-4-benzyl-3-methylpiperazin-1-yl]-3-cyclobutyl-1-cyclohexyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-[(3R)-4-benzyl-3-methylpiperazin-1-yl]-3-cyclobutyl-1-cyclohexyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-[4-(4-methylpiperazin-1-yl)phenyl]-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-{4-[(4-cyclopropylpiperazin-1-yl)methyl]phenyl}-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(2-hydroxypyridin-4-yl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(9-cyclopropyl-3,9-diazaspiro[5.5]undecan-3-yl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[(pyrrolidin-1-yl)methyl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-[2-(difluoromethoxy)pyridin-4-yl]-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[9-(propan-2-yl)-3,9-diazaspiro[5.5]undecan-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid

3-cyclobutyl-4-{4-[4-(ethoxycarbonyl)piperazin-1-yl]piperidin-1-yl}-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-(4-methoxy[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]methyl-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(9-cyclobutyl-3,9-diazaspiro[5.5]undecan-3-yl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[(2-methoxyethyl)(methyl)amino]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[4-(2-methoxyethyl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[9-(2-methoxyethyl)-3,9-diazaspiro[5.5]undecan-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-(4-hydroxy[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[4-(oxetan-3-yl)piperazin-1-yl]piperidin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[1-(propan-2-yl)octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-(1-cyclobutyloctahydro-5H-pyrrolo[3,2-c]pyridin-5-yl)-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[1-(oxetan-3-yl)octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[1-(oxan-4-yl)octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-[9-(oxetan-3-yl)-3,9-diazaspiro[5.5]undecan-3-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3,5-difluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3,4-difluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluoro-3-methoxyphenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-[3-(difluoromethoxy)phenyl]-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(bicyclo[4.2.0]octa-1,3,5-trien-3-yl)-3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3-fluoro-4-methoxyphenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(3-fluoro-5-methoxyphenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-[4-(difluoromethoxy)phenyl]-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-[3-(1,1-difluoroethyl)phenyl]-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(2,5-difluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-[6-(2-fluoroethoxy)pyridin-3-yl]-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-{2-[(oxan-4-yl)oxy]pyridin-4-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-{2-[(oxan-4-yl)methoxy]pyridin-4-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(2,4-difluorophenyl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-4-[4-(morpholin-4-yl)piperidin-1-yl]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

4-(4-cyanophenyl)-1-cyclohexyl-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(morpholin-4-yl)piperidin-1-yl]-1-{6-[(propan-2-yl)oxy]pyridin-2-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-3-hydroxy-4-(4-methoxy[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-(4-fluorophenyl)-4-(4-methoxy[1,4′-bipiperidin]-1′-yl)-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

1-cyclohexyl-4-(4-{[3-(dimethylamino)azetidin-1-yl]methyl}phenyl)-3-[(propan-2-yl)oxy]-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-1-(4-fluorophenyl)-4-(9-methyl-3,9-diazaspiro[5.5]undecan-3-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid;

3-cyclobutyl-4-[4-(ethoxycarbonyl)piperazin-1-yl]-1-(4-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid; and

3-cyclobutyl-1-(4-fluorophenyl)-4-{4-[(2-methylpropoxy)carbonyl]piperazin-1-yl}-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid.

33. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.

34. A method for treating cystic fibrosis in a subject comprising administering a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof, to a subject in need thereof.

35. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, one potentiator, and one or more additional correctors.

36. A method for treating cystic fibrosis in a subject comprising administering a compound of claim 1 or a pharmaceutically acceptable salt thereof, one potentiator, and one or more additional correctors, to a subject in need thereof.

37. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, and one or more additional therapeutic agents.

38. The pharmaceutical composition of claim 37 wherein the additional therapeutic agents are selected from the group consisting of CFTR modulators and CFTR amplifiers.

39. The pharmaceutical composition of claim 37 wherein the additional therapeutic agents are CFTR modulators.

40. A method for treating cystic fibrosis in a subject comprising administering a compound of claim 1 or a pharmaceutically acceptable salt thereof, and one or more additional therapeutic agents.

41. The method of claim 40 wherein the additional therapeutic agents are selected from the group consisting of CFTR modulators and CFTR amplifiers.

42. The method of claim 40 wherein the additional therapeutic agents are CFTR modulators.

Assignments (4)

MERGER Recorded May 13, 2020

From: ABBVIE S.Á.R.L.

To: ABBVIE OVERSEAS S.Á.R.L.

Reel/Frame 052647/0794 →

CORRECTIVE ASSIGNMENT TO CORRECT THE THIRD INVENTOR NAME PREVIOUSLY RECORDED AT REEL: 041182 FRAME: 0350. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Feb 16, 2017

From: AKKARI, RHALID; ALVEY, LUKE JONATHAN; BOCK, XAVIER MARIE; DE LEMOS, ELSA; GOSMIN, ROMAIN LUC MARIE; HOUSSEMAN, CHRISTOPHER GAËTAN; LEFRANCOIS, JEAN MICHEL; NEWSOME, GREGORY JOHN ROBERT; PIZZONERO, MATHIEU RAFAËL; DUTHION, BÉRANGER; CLAES, PIETER ISABELLE ROGER; JANSEN, KOEN KAREL; MAMMOLITI, OSCAR; MENET, CHRISTEL JEANNE MARIE; PALISSE, ADELINE MARIE ELISE; VAN DER PLAS, STEVEN EMIEL; DESROY, NICOLAS; GALAPAGOS SASU

To: GALAPAGOS NV

Reel/Frame 042522/0664 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2017

From: COWRT, MARLON D.; GFESSER, GREGORY A.; KYM, PHILIP R.; PATEL, SACHIN V.; SHRESTHA, ANURUPA; SWIFT, ELIZABETH C.; WANG, XUEQING; JI, JIANGUO

To: ABBVIE S.Á.R.L.

Reel/Frame 041123/0052 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 23, 2016

From: AKKARI, RHALID; ALVEY, LUKE JONATHAN; BOCK, XAIVIER MARIE; DE LEMOS, ELSA; GOSMINI, ROMAIN LUC MARIE; HOUSSEMAN, CHRISTOPHER GAËTAN; LEFRANCOIS, JEAN MICHEL; NEWSOME, GREGORY JOHN ROBERT; PIZZONERO, MATHIEU RAFAËL; DUTHION, BÉRANGER; CLAES, PIETER ISABELLE ROGER; JANSEN, KOEN KAREL; MAMMOLITI, OSCAR; MENET, CHRISTEL JEANNE MARIE; PALISSE, ADELINE MARIE ELISE; VAN DER PLAS, STEVEN EMIEL; DESROY, NICOLAS; GALAPAGOS SASU

To: GALAPAGOS NV

Reel/Frame 041182/0350 →

Continuity (2)

Provisional Application 62239475 · Oct 9, 2015

Related Publication 20170101406A1 · Apr 13, 2017