IP Library › Granted Patent US 9,796,774
Granted Patent B2
US 9,796,774 · App. 15/132,406 · Granted Oct 24, 2017

HIV-1 broadly neutralizing antibodies

Inventors: John Mascola (Rockville, MD); Dennis R. Burton (La Jolla, CA); Wayne Koff (Stony Brook, NY); Peter Kwong (Washington, DC); Gary Nabel (Washington, DC); Sanjay K. Phogat (Edison, NJ); Pascal Raymond Georges Poignard (San Diego, CA); Melissa Danielle De Jean St. Marcel Simek-Lemos (Brooklyn, NY); Xueling Wu (Potomac, MD); Tongqing Zhou (Boyds, MD); Zhi-Yong Yang (Potomac, MD)
Assignees: INTERNATIONAL AIDS VACCINE INITIATIVE; THE SCRIPPS RESEARCH INSTITUTE
C07K16/1063A61K39/42A61K45/06G01N33/56988A61K2039/505C07K2317/21C07K2317/33C07K2317/34C07K2317/76C07K2317/92
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Quick Facts
Patent No.
US 9,796,774
App. No.
15/132,406
Granted
Oct 24, 2017
Kind
B2
Abstract

The present application relates novel HIV-1 broadly neutralizing antibodies. The antibodies of the present invention are further characterized by their ability to bind epitopes from the Env proteins. The invention also provides light and heavy chain variable region sequences. Compositions for prophylaxis, diagnosis and treatment of HIV infection are provided.

Claims (5)

1. An isolated or non-naturally occurring VRC-PG-05 monoclonal antibody comprising a heavy chain sequence of SEQ ID NO: 8 and a light chain sequence of SEQ ID NO: 16.

2. A vector containing and expressing a nucleic acid encoding the VRC-PG-05 monoclonal antibody of claim 1 .

3. A diagnostic composition comprising a labeled antibody of claim 1 or a fragment thereof, to detect the presence of an HIV immunogen, antigen or epitope in a sample.

4. The composition of claim 3 , wherein the sample is a biological sample.

5. The composition of claim 4 , wherein the biological sample is blood, semen or vaginal fluid.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2016
From: KOFF, WAYNE; PHOGAT, SANJAY K.; POIGNARD, PASCAL RAYMOND GEORGES; SIMEK-LEMOS, MELISSA DANIELLE DE JEAN ST. MARCEL
To: INTERNATIONAL AIDS VACCINE INITIATIVE
Reel/Frame 038315/0489 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2016
From: BURTON, DENNIS R.
To: THE SCRIPPS RESEARCH INSTITUTE
Reel/Frame 038315/0558 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2016
From: MASCOLA, JOHN; KWONG, PETER; NABEL, GARY; WU, XUELING; YANG, ZHI-YONG; ZHOU, TONGQING
To: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Reel/Frame 038315/0627 →
Continuity (5)
Continuation 13792098 · Mar 10, 2013
Continuation In Part PCTUS2011052933 · Sep 23, 2011
Provisional Application 61515528 · Aug 5, 2011
Provisional Application 61386211 · Sep 24, 2010
Related Publication 20160289305A1 · Oct 6, 2016