Anaerobic blood storage containers
A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.
1. A blood storage device 20 for storing oxygen depleted blood comprising:
outer receptacle 201 substantially impermeable to oxygen;
a mesh spacer 213 ;
a collapsible blood container 202 ; at least one inlet/outlet 30 that is substantially impermeable to oxygen passing through said outer receptacle 201 and that is in fluid communication with said collapsible container 202 ; and
an oxygen and carbon dioxide sorbent 207 situated within said outer receptacle 201 , wherein said at least one inlet/outlet 30 comprises a unitary tube that is substantially impermeable to oxygen comprising tubing 304 , bond 302 , and tubing 205 , wherein said unitary tube is a barrier traversing tube 305 comprising an outer layer 308 , an inner layer 306 , and an oxygen barrier layer 307 .
2. The blood storage device of claim 1 , wherein said outer receptacle 201 that is substantially impermeable to oxygen consists of a heat sealable polyethylene (PE) inner layer, an alumina barrier middle later, and a polyethylene terephthalate (PET) layer.
3. The blood storage device of claim 1 , wherein said outer receptacle that is substantially impermeable to oxygen comprises a polyethylene terephthalate (PET).
4. The blood storage device of claim 3 , wherein said PET further comprises a barrier coating of silica or alumina.
5. The blood storage device of claim 3 , wherein said outer receptacle further comprises a polyolefin inner layer.
6. The blood storage device of claim 1 , wherein said collapsible blood container 202 comprises PVC with DEHP.
7. The blood storage device of claim 1 , wherein said collapsible blood container 202 has a moisture vapor transmission rate (MVTR) of 10 g/m 2 /24 hrs or less when tested at a temperature of 23+2° C.
8. The blood storage device of claim 1 , wherein said oxygen and carbon dioxide sorbent 207 consists of iron powders.
9. The blood storage device of claim 1 , wherein said oxygen and carbon dioxide sorbent 207 has a capacity of at least 100 cc oxygen.
10. The blood storage device of claim 1 , wherein said blood storage device 20 includes from 0.5 to 150 grams of said oxygen and carbon dioxide sorbent 207 in one or more sachets.
11. The blood storage device of claim 10 , wherein said oxygen and carbon dioxide sorbent 207 is provided as a single sachet comprising 8 grams of sorbent, situated outside of said collapsible blood container 202 .
12. The blood storage device of claim 1 , wherein said tubing 205 comprises PVC having a Barrer value of less than 3 Barrer.
13. The blood storage device of claim 1 , wherein said outer layer 308 consists of polythelene (PE), said inner layer 306 consists of PVC, and said oxygen barrier layer 307 consists of EVA.
14. The blood storage device of claim 1 , further comprising a headspace comprising a volume between said outer receptacle 201 and said collapsible blood container 202 is maintained at a partial pressure of oxygen (PO 2 ) of less than 15 mmHg during a storage period of at least 64 days.
15. The blood storage device of claim 1 , further comprising an oxygen indicator.
16. The blood storage device of claim 1 , further comprising hanging feature 203 .
17. The blood storage device of claim 1 , wherein said oxygen depleted blood stored in said collapsible blood container 202 maintains an oxygen saturation level (SO 2 ) during a storage period that increases less than 5% over said oxygen saturation level at the beginning of storage.
18. The blood storage device of claim 1 , wherein said collapsible blood container 202 has an oxygen permeability of between 3 and 350 Barrer.
19. The blood storage device of claim 18 , wherein said collapsible blood container 202 has said oxygen permeability of between 3 and 11 Barrer.
20. The blood storage device of claim 1 , further comprising a locating feature adapted to align said collapsible blood container 202 with the geometry of said outer receptacle 201 .