Magnetic nanostructures as theranostic agents
The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.
1. A method, comprising
a) administering a magnetic nanostructure comprising i) a magnetic nanostructure coated with a non-magnetic coating; and ii) a targeting agent, wherein said targeting agent targets said nanostructure to a Medulloblastoma cell of a subject;
b) detecting the presence of said cancer cell in said subject by identifying said magnetic nanostructure; and
c) destroying said cancer cell by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.
2. The method of claim 1 , wherein said identifying said magnetic nanostructure comprises the use of magnetic resonance imaging.
3. The method of claim 1 , wherein said targeting agent is an antibody.
4. The method of claim 1 , wherein said magnetic nanostructure is present in a stable suspension.
5. A method, comprising
a) administering a magnetic nanostructure comprising i) a magnetic nanostructure coated with a non-magnetic coating; and ii) a targeting agent, wherein said targeting agent targets said nanostructure to a Medulloblastoma cell to a subject; and
b) detecting the presence of said cancer cell in said subject by identifying said magnetic nanostructure.
6. The method of claim 5 , further comprising the step of destroying said cancer cell by exposing said magnetic nanostructure to a radio frequency that causes said magnetic nanostructure to generate heat.
7. The method of claim 5 , wherein said identifying said magnetic nanostructure comprises the use of magnetic resonance imaging.
8. The method of claim 5 , wherein said targeting agent is an antibody.
9. The method of claim 5 , wherein said magnetic nanostructure is present in a stable suspension.