IP Library › Granted Patent US 9,808,475
Granted Patent B2
US 9,808,475 · App. 14/871,577 · Granted Nov 7, 2017

Bovine milk oligosaccharides

Inventors: J. Bruce German (Davis, CA); David Mills (Davis, CA); Carlito B. Lebrilla (Davis, CA); Daniela Barile (Davis, CA); Riccardo LoCascio (Sacramento, CA)
Assignee: The Regents of the University of California
A61K31/702A23L33/135A23L33/28A23L33/40A61K31/715A61K31/726A61K35/741A61K35/745A61K36/062C08B37/0003C08B37/006C08B37/0063C08L5/00C12P19/14C12P19/18A23V2002/00
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Quick Facts
Patent No.
US 9,808,475
App. No.
14/871,577
Granted
Nov 7, 2017
Kind
B2
Abstract

Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

Claims (61)

1. A food product for a human or non-human animal, the food product comprising a powder composition comprising one or more oligosaccharide from bovine milk or bovine milk product and an inoculum of Bifidobacterium longum subsp. infantis or B. breve , wherein the oligosaccharide is from Table 1 and is selected from the group consisting of:

an oligosaccharide consisting of 3 Hexose (Hex) moieties, 4 N-acetyl hexosamine (HexNAc) moieties and 1 fucose (Fuc) moiety;

an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 3 Hex moieties and 6 HexNAc moieties,

an oligosaccharide consisting of 4 Hex moieties and 3 HexNAc moieties;

an oligosaccharide consisting of 3 Hex moieties and 4 HexNAc moieties;

an oligosaccharide consisting of 6 Hex moieties and 2 HexNAc moieties;

an oligosaccharide consisting of 4 Hex moieties and 4 HexNAc moieties;

an oligosaccharide consisting of 3 Hex moieties and 5 HexNAc moieties;

an oligosaccharide consisting of 5 Hex moieties and 4 HexNAc moieties;

an oligosaccharide consisting of 4 Hex moieties and 5 HexNAc moieties; and

a mixture thereof.

2. The food product of claim 1 , comprising at least two oligosaccharides selected from selected from the group consisting of:

an oligosaccharide consisting of 3 Hex moieties, 4 HexNAc moieties and 1 fucose (Fuc) moiety;

an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 3 Hexose (Hex) moieties and 6 N-acetyl hexosamine (HexNAc) moieties,

an oligosaccharide consisting of 4 Hex moieties and 3 HexNAc moieties;

an oligosaccharide consisting of 3 Hex moieties and 4 HexNAc moieties;

an oligosaccharide consisting of 6 Hex moieties and 2 HexNAc moieties;

an oligosaccharide consisting of 4 Hex moieties and 4 HexNAc moieties;

an oligosaccharide consisting of 3 Hex moieties and 5 HexNAc moieties;

an oligosaccharide consisting of 5 Hex moieties and 4 HexNAc moieties; and

an oligosaccharide consisting of 4 Hex moieties and 5 HexNAc moieties.

3. The food product of claim 1 , comprising one or more of

an oligosaccharide consisting of 3 Hex moieties, 4 HexNAc moieties and 1 fucose (Fuc) moiety;

an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety;

an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety; or

an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety.

4. The food product of claim 1 , wherein the concentration of the oligosaccharide in the composition is from 100 micrograms/L to 25 grams/L.

5. The food product of claim 1 , wherein the composition is selected from the group consisting of a tablet, a capsule, a medical food, or a medical product.

6. The food product of claim 1 , wherein said food product is selected from the group consisting of an infant formula, follow-on formula, toddler's beverage, milk, fruit juice, and fruit-based drink.

7. The food product of claim 1 , wherein the oligosaccharide has been purified from bovine milk or a bovine milk product.

8. The food product of claim 1 , further comprising an inoculum of a fungus or yeast.

9. The food product of claim 1 , wherein the inoculum is an inoculum of Bifidobacterium longum subsp. infantis.

10. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties, 4 HexNAc moieties and 1 fucose (Fuc) moiety.

11. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety.

12. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety.

13. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 5 Hex moieties, 4 HexNAc moieties, and 1 Fuc moiety.

14. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties, 5 HexNAc moieties, and 1 Fuc moiety.

15. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties, 6 HexNAc moieties, and 1 Fuc moiety.

16. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties and 6 HexNAc moieties.

17. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties and 3 HexNAc moieties.

18. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties and 4 HexNAc moieties.

19. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 6 Hex moieties and 2 HexNAc moieties.

20. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties and 4 HexNAc moieties.

21. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 3 Hex moieties and 5 HexNAc moieties.

22. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 5 Hex moieties and 4 HexNAc moieties.

23. The food product of claim 1 , wherein the oligosaccharide is an oligosaccharide consisting of 4 Hex moieties and 5 HexNAc moieties.

24. The food product of claim 1 , wherein the food product is an infant cereal or an adult cereal.

25. The food product of claim 1 , wherein the food product is a human food product.

26. The food product of claim 1 , wherein the food product is in dose form and the inoculum of Bifidobacterium longum subsp. infantis or B. breve is present at a level of from 10 4 to 10 12 cfu/dose.

Continuity (3)
Continuation 13809556
Provisional Application 61363432 · Jul 12, 2010
Related Publication 20160143928A1 · May 26, 2016