Flexible valve structure for implantable reservoir
In various embodiments, implants including reservoirs, such as intraocular lenses, feature flexible membranes and valves integrated therewith, the valves having apertures that are normally closed.
1. An inflatable intraocular lens (IOL) implantable in a human eye, the intraocular lens including a reservoir configured to receive an optically clear filling fluid and expand in response thereto, the reservoir comprising:
a flexible membrane defining an interior volume; and
a self-sealing valve integrated with the membrane, the valve comprising (i) a plurality of contiguous polymeric segments and (ii) a pre-formed aperture extending through at least one of the segments and into the interior volume,
wherein a first portion of the valve is disposed outside of the interior volume, and a second portion of the valve is disposed within the interior volume,
wherein the aperture is normally closed to prevent fluid flow therethrough but is openable in response to applied pressure from a blunt needle passing through to an interior of the intraocular lens in order to fill or adjust the optically clear fluid within the reservoir,
wherein at least one of the segments has a physical or chemical property affecting self-sealing of the aperture that differs from that of at least one of the other contiguous segments,
wherein a first one of the segments surrounds and fully encapsulates a second one of the segments, the pre-formed aperture extending through both the first and second ones of the segments,
wherein the first one of the segments is made of a higher durometer material to provide improved mechanical support and to enhance self-sealing,
wherein the second one of the segments comprises a pharmaceutical agent disposed therewithin and is made of a lower durometer material to provide short-term release of said pharmaceutical agent, and
wherein the valve is deformable, whereby, in response to fluid pressure within the interior volume, a portion of the aperture experiences compressive force acting to close the aperture.
2. The intraocular lens (IOL) of claim 1 , wherein (i) a first portion of the aperture extends along a first direction through one of the segments, and (ii) a second portion of the aperture extends along a second direction through another one of the segments, the second direction being different from the first direction.
3. The intraocular lens (IOL) of claim 1 , wherein at least two of the segments have different polarities, whereby the at least two of the segments function as a diffusion barrier.
4. The intraocular lens (IOL) of claim 1 , wherein the membrane defines said intraocular lens.
5. The intraocular lens (IOL) of claim 1 , wherein a diameter of the first portion of the valve is greater than a diameter of the second portion of the valve.
6. The intraocular lens (IOL) of claim 1 , wherein (i) the aperture extends through the first portion of the valve, and (ii) the second portion of the valve defines a normally open tunnel fluidly connected to the aperture.
7. The intraocular lens (IOL) of claim 1 , wherein the valve is configured to deform in response to deformation of the flexible membrane.
8. The intraocular lens (IOL) of claim 1 , wherein the valve is configured to deform in response to one or more fill characteristics of the reservoir.
9. The intraocular lens (IOL) of claim 8 , wherein the one or more fill characteristics comprise at least one of fill percentage, fill volume, or reservoir fluid pressure.
10. The intraocular lens (IOL) of claim 1 , wherein the valve defines a recessed indentation leading into the aperture.
11. The intraocular lens (IOL) of claim 1 , wherein the valve is deformable, whereby, in response to fluid pressure within the interior volume, the first portion of the valve experiences tensile force.
12. The intraocular lens (IOL) of claim 1 , wherein the valve is deformable, whereby, in response to fluid pressure within the interior volume, the second portion of the valve experiences compressive force acting to close the aperture.