IP Library Granted Patent US 9,828,361
Granted Patent B2
US 9,828,361 · App. 15/040,971 · Granted Nov 28, 2017

Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same

Inventors: Hon-Wah Man (Princeton, NJ); Roger Shen-Chu Chen (Edison, NJ); George W. Muller (Rancho Santa Fe, CA); Alexander L. Ruchelman (Cream Ridge, NJ); Ehab M. Khalil (Whitehouse Station, NJ); Weihong Zhang (Highland Park, NJ)
Assignee: Celgene Corporation
C07D401/12C07D401/04C07D401/14C07D407/12C07D407/14C07D409/14C07D413/14C07D417/14C07D471/04C07D487/04C07D491/107C07D493/04C07D495/04
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Quick Facts
Patent No.
US 9,828,361
App. No.
15/040,971
Granted
Nov 28, 2017
Kind
B2
Abstract

Provided are 4′-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.

Claims (13)

1. A compound of the formula:

or a pharmaceutically acceptable salt or stereoisomer thereof.

2. The compound of claim 1 , which is

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 , which is

4. The compound of claim 1 , which is

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 4 , which is

6. A pharmaceutical composition comprising a compound of claim 1 and one or more excipients.

7. A pharmaceutical composition comprising a compound of claim 2 and one or more excipients.

8. A pharmaceutical composition comprising a compound of claim 3 and one or more excipients.

9. A pharmaceutical composition comprising a compound of claim 4 and one or more excipients.

10. A pharmaceutical composition comprising a compound of claim 5 and one or more excipients.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 30, 2016
From: MAN, HON-WAH; MULLER, GEORGE W.; RUCHELMAN, ALEXANDER L.; KHALIL, EHAB M.; CHEN, ROGER SHEN-CHU; ZHANG, WEIHONG
To: CELGENE CORPORATION
Reel/Frame 039057/0618 →
Continuity (4)
Continuation 13952386 · Jul 26, 2013
Division 13025105 · Feb 10, 2011
Provisional Application 61303618 · Feb 11, 2010
Related Publication 20160159768A1 · Jun 9, 2016