IP Library › Granted Patent US 9,855,293
Granted Patent B2
US 9,855,293 · App. 15/069,684 · Granted Jan 2, 2018

Non-reducing end unsaturated mannuronic acid oligosaccharides and compositions containing same as active ingredient

Inventor: Du Woon Kim (Gwangju, KR)
Assignee: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
A61K31/715A61K31/565
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Quick Facts
Patent No.
US 9,855,293
App. No.
15/069,684
Granted
Jan 2, 2018
Kind
B2
Abstract

Disclosed is a non-reducing end unsaturated mannuronic acid oligosaccharide having a molecular weight of 100-3000 Da, which is obtained by lysing polymannuronate as a substrate with alginate lyase, and provided are: a non-reducing end unsaturated mannuronic acid oligosaccharide; and pharmaceutical compositions for alleviating, preventing, or treating obesity, diabetes, and climacteric syndrome, and probiotics for promoting intestinal beneficial bacteria, the compositions and probiotics containing, as an active ingredient, the non-reducing end unsaturated mannuronic acid oligosaccharide, so that the antiobesity and antidiabetic effects, estrogen activity, and intestinal microflora controlling effect of the non-reducing end unsaturated mannuronic acid oligosaccharides are remarkably excellent as compared with non-reducing end saturated mannuronic acid oligosaccharides.

Claims (4)

1. A pharmaceutical composition comprising a non-reducing end unsaturated alginate oligosaccharide having a molecular weight of 100-3,000 Da, and 17β-estradiol,

wherein the alginate oligosaccharide is obtained by lysing polymannuronate as a substrate with alginate lyase.

2. The composition of claim 1 , wherein the non-reducing end unsaturated alginate oligosaccharide comprises one to ten mannuronic acids or guluronic acids.

3. The composition of claim 1 , wherein the ratio of mannuronic acid:guluronic acid is 1.2-5.0:1.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2022
From: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
To: BIO3S CO.,LTD.
Reel/Frame 058701/0313 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 14, 2016
From: KIM, DU WOON
To: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY
Reel/Frame 037970/0474 →
Priority Claims (1)
KR 10-2015-0043404 · Mar 27, 2015 · national
Continuity (1)
Related Publication 20170065629A1 · Mar 9, 2017