Methods for treating overweight or obesity
The present invention relates to methods of managing weight, and treating overweight or obesity and treating or preventing diabetes in a subject in need thereof. In one embodiment, the method comprises the steps of (a) orally administering to the subject from about 0.7 g to about 4 g of crosslinked carboxymethylcellulose; and (b) orally administering to the subject at least about 100 mL of water per gram of crosslinked carboxymethylcellulose. Steps (a) and (b) are conducted prior to or with at least one meal per day.
1. A method for treating overweight or obesity in a subject in need thereof, wherein the subject has a fasting blood glucose level of 90 mg/dL, or higher: said method comprising the steps of:
(a) orally administering to the subject from about 1.5 g to about 3 g of a crosslinked carboxymethylcellulose; and
(b) orally administering to the subject at least 100 mL water per gram of the crosslinked carboxymethylcellulose,
wherein said steps (a) and (b) are conducted prior to or with a meal, wherein the carboxymethylcellulose is crosslinked with citric acid and is characterized by:
(a) a tapped density of at least about 0.6 g/mL;
(b) an elastic modulus of at least about 350 Pa, and
(c) a media uptake ratio of at least about 50 in a 1:8 mixture of simulated gastric fluid and water.
2. The method of claim 1 , wherein the amount of crosslinked carboxymethylcellulose administered step (a) is from about 1.75 g to about 2.75 g.
3. The method of claim 2 , wherein the amount of crosslinked carboxymethylcellulose administered in step (a) is about 2.25 g.
4. The method of claim 1 , wherein the subject has a body mass index of 30 or higher.
5. The method of claim 1 , wherein the subject has a fasting blood glucose level of 93 mg/dL or higher.
6. The method of claim 1 , wherein the subject has a fasting blood glucose level of 95 mg/dL or higher.
7. The method of claim 1 , wherein the subject has a fasting blood glucose level in the range of 100 to 125.9 mg/dL.
8. The method of claim 1 , wherein the subject has a fasting blood glucose level from 90 to 125.9 mg/dL.
9. The method of claim 1 , wherein the amount of water administered in step (b) is at least about 125 mL per gram of crosslinked carboxymethylcellulose.
10. The method of claim 1 , wherein the amount of water administered in step (b) is at least about 150 mL per gram of crosslinked carboxymethylcellulose.
11. The method of claim l, wherein the water content of the crosslinked carboxymethylcellulose is 10% wt/wt or less.
12. The method of claim 1 , wherein the crosslinked carboxymethylcellulose is produced by a method comprising the steps of:
(a) providing a solution of carboxymethylcellulose sodium salt and citric acid in water, said solution consisting essentially of about 5% to about 7% carboxymethylcellulose by weight relative to the weight of the water and citric add in an amount of about 0.15% to about 0.35% by weight relative to the weight of the carboxymethylcellulose;
(b) maintaining the solution at a temperature from about 40° C. to about 80° C., to evaporate the water and form a substantially dry solid residue;
(c) grinding the residue to form residue particles; and
(d) heating the residue particles to a temperature from about 80° C. to about 150° C. for a period of time sufficient to crosslink the carboxymethylcellulose.