Device for administering cells and cell-therapy methods using said device

1. A device for cell therapy, said device being designed to be applied on a living tissue of a biological conduit or a hollow organ and having at least a biocompatible first wall which forms a cavity between said first wall and said tissue, and further comprising:

means to feed a healing substance into said cavity; and

a second wall comprising at least a porous part, the cavity being provided between said first and second walls, the healing substance being administered through said porous part, wherein the healing substance in the cavity is a suspension of cells, said second wall being bioresorbable; wherein said device comprising a generally tubular shape, the first wall being a tight internal wall, and the second wall being an external wall, and a stent provides a radial expansion of the device to bring an outward radial pressure on the internal wall so as to urge said internal wall toward said external wall, and the internal wall exerts a pressure on the suspension of cells, the pressure being sufficient for the suspension of cells to move through the porous part of the second wall while allowing fluid flow in the biological conduit or the hollow organ during treatment;

wherein said means to feed comprises a valve to connect a feeding catheter to supply the suspension of cells and, after feeding, to prevent the supplied suspension of cells to leak through said means to feed.

2. The device according to claim 1 , wherein the suspension of cells are gingival fibroblasts.

3. A method for treating a patient in need of cell therapy, wherein a therapeutically effective quantity of cells suitable for said cell therapy is administered with a device according to claim 2 .

4. The device according to claim 1 , wherein the stent is autoexpandable.

5. The device according to claim 1 , wherein the means to feed the suspension of cells is in place during treatment.

6. A method for treating defects of biological conduits or of hollow organs in a patient, comprising:

implanting a device according to claim 1 at a site of defect of a biological conduit or of a hollow organ;

filling said device with a suspension of cells suitable to treat said defect; and

maintaining the device in place at least for a time sufficient for a therapeutically effective quantity of cells to have migrated in direction of the defect and/or for the cells to have exerted a therapeutically effective paracrine effect.

7. The method according to claim 6 , wherein the defect is a vascular defect.

8. The method according to claim 6 , wherein the cells suitable to treat the defect are gingival fibroblasts.

9. The method according to claim 6 , wherein a filling of the cavity is made during treatment.