Processes for the preparation of uracil derivatives
The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
1. A process for preparing a compound of structure:
wherein:
R 1a , R 1b and R 1c are the same or different and independently hydrogen, halogen, C 1-4 alkyl, hydroxy or alkoxy;
R 2a and R 2b are the same or different and independently hydrogen, halogen, trifluoromethyl, cyano or —SO 2 CH 3 ;
R 3 is hydrogen or methyl; and
comprising:
reacting a compound of structure (VII):
wherein R 2a , R 2b and R 3 are as defined above;
with a compound of structure (VIII):
wherein R is H or C 1-4 alkyl, R′ is H or C 1-4 alkyl or R and R′ taken together form C 1-6 alkanediyl; and
R 1a , R 1b , and R 1c are as defined above.
2. The process of claim 1 wherein R 1a is halogen, R 1b is methoxy and R 1c is H.