Utility of nematode small molecules
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating an immune and inflammatory disorders disorder by administering a composition comprising a therapeutically effective dosage of an ascaroside compound, or a mixture of ascaroside compounds, or a mixture containing at least one ascaroside.
1. A method of alleviating or treating an inflammatory disorder in a human subject, comprising:
administering to the subject a composition comprising isolated ascr#7
or a salt thereof; and
wherein the inflammatory disorder is asthma, inflammatory bowel disease, or type one diabetes.
2. The method of claim 1 , wherein the method reduces mucus production in the subject.
3. The method of claim 1 , wherein the naturally occurring ascaroside is produced from a Nippostrongylus brasiliensis.
4. The method of claim 1 , wherein the inflammatory disorder is asthma.
5. The method of claim 1 , wherein the inflammatory disorder is inflammatory bowel disease.
6. The method of claim 1 , wherein the inflammatory disorder is type one diabetes.