Endolysins active against
The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage GRCS.
1. A method of treating a Staphylococcal infection in a subject comprising administering to said subject a therapeutically effective amount of an isolated polypeptide comprising the amino acid sequence of SEQ ID NO: 6.
2. The method of claim 1 , wherein said isolated polypeptide further comprises the amino acid sequence of SEQ ID NO: 7.
3. The method of claim 1 , wherein said isolated polypeptide comprises the amino acid sequence of SEQ ID NO: 5.
4. The method of claim 1 , comprising the further step of administering to said subject a secondary therapeutic agent after or concurrent with said administration of said isolated polypeptide.
5. The method of claim 4 , wherein said secondary therapeutic agent is one or more antibiotic.
6. The method of claim 5 , wherein said antibiotic is selected from the group consisting of a penicillin, a cephalosporin, a polymyxin, an ansamycin, a quinolone, a sulfonamide, a lipopeptide, a glycycline, and an oxazolidinone.
7. The method of claim 5 , wherein said antibiotic is selected from the group consisting of linezolid, daptomycin, and tigecycline, vancomycin, fidaxomicin, and metronidazole.
8. The method of claim 1 , wherein said Staphylococcal infection is caused by strain S. aureus.