Peracid-generating compositions

1. A tooth whitening strip comprising

a hydratable adhesive film with a first side and a second side, the first side having a granular bleaching ingredient attached thereto, wherein the strip comprises, in or on the film or in the form of granules attached to the first side of the film,

(i) a granulated protein having perhydrolase activity which contains the catalytic domain of a member of the carbohydrate esterase family 7; and

(ii) a carboxy donor,

wherein upon use, the peroxide released by the granular bleaching ingredient reacts with the carboxy donor in the presence of the perhydrolase to form a peracid;

wherein the granulated protein having perhydrolase activity comprises an amino acid sequence selected from SEQ ID NO: 1;

wherein the tooth whitening strip comprises a backing layer;

wherein the carboxy donor is 1,2,3-triacetoxypropane;

wherein the hydratable adhesive film comprises hydroxypropylmethylcellulose (HPMC); and

wherein the granules immediately dissolve and become active when exposed to saliva or other sources of water.

2. The tooth whitening strip according to claim 1 , wherein the protein having perhydrolase activity has affinity for oral tissue and further comprises an amino acid sequence selected from

a)

SEQ ID NO: 2

MAFFDLPLEELKKYRPERYEEKDFDEFWEETLAESEKFPLDPVFERMESH

LKTVEAYDVTFSGYRGQRIKGWLLVPKLEEEKLPCVVQYIGYNGGRGFPH

DWLFWPSMGYICFVMDTRGQGSGWLKGDTPDYPEGPVDPQYPGFMTRGIL

DPRTYYYRRVFTDAVRAVEAAASFPQVDQERIVIAGGSQGGGIALAVSAL

SKKAKALLCDVPFLCHFRRAVQLVDTHPYAEITNFLKTHRDKEEIVFRTL

SYFDGVNFAARAKIPALFSVGLMDNISPPSTVFAAYNYYAGPKEIRIYPY

NNHEGGGSFQAVEQVKFLKKLFEKGGPGSGGAGSPGSAGGPGSTKPPRTP

TANTSRPHHNFGSGGGGSPHHHHHH,

and

and

b) an amino acid sequence having at least 80%, sequence identity to SEQ ID NO: 2.

3. The tooth whitening strip according to claim 1 wherein the granular bleaching ingredient is coated with a quickly dissolving material.

4. The tooth whitening strip according to claim 1 wherein the granular bleaching ingredient is selected from solid peroxides and solid peroxide donors.

5. The tooth whitening strip according to claim 1 wherein the granular bleaching ingredient is selected from peroxide salts or complexes, peroxyphosphate, peroxycarbonate, perborate, peroxysilicate, persulphate salts, calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, potassium persulfate, hypochlorites, urea peroxide, hydrogen peroxide polymer complexes, hydrogen peroxide-polyvinyl pyrrolidone polymer complexes, metal peroxides, zinc peroxide, calcium peroxide, peracids, and combinations thereof.

6. The tooth whitening strip according to claim 1 wherein the granular bleaching ingredient comprises urea peroxide.

7. The tooth whitening strip according to claim 1 wherein the particle size (D50) of the granular bleaching ingredient is 10-200 microns.

8. The tooth whitening strip according to claim 7 wherein the granular bleaching ingredient comprises 0.1% or less of the total weight of the hydratable adhesive film and a granular bleaching ingredient attached thereto.

9. The tooth whitening strip according to claim 8 wherein the amount of granular bleaching agent on the first side of the hydratable adhesive film is 0.001-1 mg/cm 2 .

10. The tooth whitening strip according to claim 1 which comprises a peracid or which generates a peracid upon use.

11. The tooth whitening strip according to claim 1 wherein the ingredients are present in amounts sufficient to provide, upon mixing, a bleaching agent in an amount and concentration effective to whiten teeth.

12. The tooth whitening strip according to claim 1 wherein the hydratable adhesive film further comprises one or more water-soluble polymers selected from a hydrophilic cellulose ether, carboxymethyl cellulose, hydroxypropyl cellulose, a polyvinyl acetate, a carbomer, a polysaccharide gum, xanthan gum, a modified food starch, gelatin, animal or fish-based gelatin, a cross-linked carboxyvinyl copolymer, a cross-linked polyvinylpyrrolidone, polyethylene oxide, a polyacrylic acid, a polyacrylate, a polyvinyl alcohol, alginate, casein, pullulan, and a combination of two or more thereof.

13. The tooth whitening strip according to claim 1 , wherein the hydratable adhesive film comprises one or more water-soluble polymers selected from a hydrophilic cellulose ether, a polyvinyl alcohol, a carbomer, and a combination of two or more thereof.

14. The tooth whitening strip according to claim 1 , wherein the hydratable adhesive film further comprises a plasticizer.

15. The tooth whitening strip according to claim 1 , wherein the hydratable adhesive film further comprises propylene glycol.

16. The tooth whitening strip according to claim 1 , wherein the granular bleaching ingredient is coated with a water soluble coating capable of dissolving upon hydration.

17. The tooth whitening strip according to claim 1 , wherein an effective amount of a peracid is generated at a substantially uniform concentration across the surface of the tooth whitening strip.

18. A method of whitening teeth comprising

a) providing a packaging system comprising the tooth whitening strip according to claim 1 ;

b) removing the tooth whitening strip from the packaging system; and

c) contacting the tooth whitening strip directly to the teeth for a period of time sufficient to whiten the teeth; wherein the tooth whitening strip is hydrated by moisture present in the oral cavity or on the tooth surface or is hydrated after step (b) but prior to step (c).