Cannabidiol for treatment of severe and refractory graft-versus-host disease
The invention provides methods for preventing, ameliorating and treating the acute and chronic forms of graft-versus-host disease (GVHD) by using Cannabidiol compositions.
1. A method for treating a subject afflicted with acute graft versus host disease (GVHD) or chronic GVHD comprising administering to said subject a therapeutically effective amount of a composition comprising a cannabidiol (CBD), (−)-7-hydroxy-CBD, (−)-CBD-7-oic acid, dimethylheptyl homologue of (−)-7-hydroxy-CBD, or dimethylheptyl homologue of (−)-CBD-7-oic acid, thereby treating a subject afflicted with acute graft versus host disease (GVHD) or chronic GVHD wherein the composition is administered daily in doses of between 5 mg to 600 mg.
2. The method of claim 1 , wherein the acute GVHD is Grade III acute GVHD.
3. The method of claim 1 , wherein the acute GVHD is Grade IV acute GVHD.
4. The method of claim 1 , wherein the acute GVHD, the chronic GVHD, or both is/are refractory to a steroid treatment.
5. The method of claim 1 , wherein the chronic GVHD is severe chronic GVHD.
6. The method of claim 1 , wherein the chronic GVHD is classic or overlap chronic GVHD.
7. The method of claim 1 , wherein the composition is a systemic composition.
8. The method of claim 1 , wherein the composition is an oral composition or a topical composition.
9. The method of claim 1 , further comprising administering to the subject at least one additional GVHD therapeutic agent.
10. The method of claim 1 , wherein the CBD, is administered to the subject prior to or following diagnosis of acute or chronic GVHD in the subject.
11. The method of claim 1 , further comprising administering a steroid to said subject.