IP Library Granted Patent US 9,931,477
Granted Patent B2
US 9,931,477 · App. 14/519,114 · Granted Apr 3, 2018

Methods and devices for sensing tissues and tissue compartments

Inventors: Erik Bassett (Watertown, MA); Jeffrey M. Karp (Brookline, MA); Robert S. Langer (Newton, MA); Omid C. Farokhzad (Chestnut Hill, MA); Alexander H. Slocum (Bow, NH)
Assignees: The Brigham and Women's Hospital, Inc.; Massachusetts Institute of Technology
A61M5/3287A61B17/3401A61B2090/064
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,931,477
App. No.
14/519,114
Granted
Apr 3, 2018
Kind
B2
Abstract

An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advanced into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus. An inner core may be advanced into the low resistance material for deployment of a gas or a liquid as desired.

Claims (16)

1. An apparatus comprising:

a penetrating medical device having a lumen, a distal tip, and an opening at or near the distal tip; and

a movable membrane positioned within the lumen and having an exposed surface at the opening that is at or near the distal tip, the movable membrane being coupled to a pressurized fluid held within the penetrating medical device by the movable membrane; wherein

the apparatus is configured such that with the fluid pressurized, when the exposed surface of the movable membrane is positioned within a first matter having a first resistance, the movable membrane is in a pressurized state and remains within the lumen, and upon advancement of the exposed surface into a second matter having a second resistance that is sufficiently lower than the first resistance, at least a portion of the movable membrane moves outside the lumen.

2. The apparatus as in claim 1 , further comprising a sensor for measuring a pressure or a flow rate of the fluid.

3. The apparatus of claim 1 , further comprising means for sensing a pressure of the fluid.

4. The apparatus as in claim 1 , wherein the movable membrane comprises a portion of a surface of a balloon containing the fluid.

5. The apparatus as in claim 1 , wherein the penetrating medical device comprises a needle, and further comprising a stylet inserted within the needle, wherein the first movable membrane is a movable membrane disposed on a distal tip of the stylet.

6. An apparatus comprising:

a penetrating medical device having a lumen, a distal tip, and an opening at or near the distal tip; and

a movable membrane positioned within the lumen and having an exposed surface at the opening that is at or near the distal tip, the movable membrane being coupled to a pressurized fluid held within the penetrating medical device by the movable membrane; wherein

the apparatus is configured such that with the fluid pressurized, when the exposed surface of the movable membrane is positioned within a first matter having a first resistance, the movable membrane remains within the lumen, and upon advancement of the exposed surface into a second matter having a second resistance that is sufficiently lower than the first resistance, at least a portion of the movable membrane moves through the opening and outside the lumen.

7. The apparatus as in claim 6 , further comprising a sensor for measuring a pressure or a flow rate of the fluid.

8. The apparatus of claim 6 , further comprising a means for sensing a pressure of the fluid.

9. The apparatus as in claim 8 , wherein the movable membrane comprises a portion of a surface of a balloon containing the fluid.

10. The apparatus as in claim 6 , wherein the penetrating medical device comprises a needle, and further comprising a stylet inserted within the needle, wherein the movable membrane is a movable membrane disposed on a distal tip of the stylet.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jan 6, 2022
From: BRIGHAM AND WOMEN'S HOSPITAL
To: THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY
Reel/Frame 058580/0403 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2014
From: FAROKHZAD, OMID C.
To: THE BRIGHAM & WOMEN'S HOSPITAL
Reel/Frame 034088/0090 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2014
From: SLOCUM, ALEXANDER; BASSETT, ERIK; KARP, JEFFREY M.; LANGER, ROBERT S.
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 034088/0100 →
Continuity (3)
Division 12525931
Provisional Application 60899920 · Feb 7, 2007
Related Publication 20150112261A1 · Apr 23, 2015