Antibody that binds murine wise protein
The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to subjects in order to prevent or treat renal degeneration or damage.
1. An isolated antibody that specifically binds to the contiguous amino acids contained in amino acid numbers 50-62 or 68-80 of SEQ ID NO: 216.
2. The isolated antibody of claim 1 , wherein the antibody is selected from the group consisting of a monoclonal antibody, a polyclonal antibody, a Fv fragment of an antibody, a Fab fragment of an antibody, a F(ab′) 2 fragment of an antibody, a recombinant single chain Fv fragment (scFv), a diabody, a triabody, and a tetrabody.
3. The isolated antibody of claim 2 , wherein the antibody is a monoclonal antibody.
4. The isolated antibody of claim 1 , wherein the antibody is a monoclonal antibody.
5. An isolated antibody that specifically binds to amino acid numbers 83-98 of SEQ ID NO: 216.
6. The isolated antibody of claim 5 , wherein the antibody is a monoclonal antibody.