Polymer particles
Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.
1. An embolic system including:
a delivery device; and
an embolic solution including polymer particles, wherein the polymer particles include:
an acrylate, acrylamide, methacrylamide, methyl methacrylate, or a combination thereof, and
a crosslinker,
wherein the polymer particles have a spherical diameter between about 40 μm and about 1,200 μm.
2. The embolic system of claim 1 , wherein the polymer particles are susceptible to degradation through hydrolysis or enzymatic action, and wherein the degradation provides less than about 10% of the polymer particles intact after about 5 days.
3. The embolic system of claim 1 , wherein the spherical diameter is between about 75 μm and about 1,200 μm.
4. The embolic system of claim 1 , wherein the crosslinker includes at least two functional groups.
5. The embolic system of claim 1 , wherein the crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action.
6. The embolic system of claim 1 , wherein the crosslinker is bis-glycidyl amino alcohol,
wherein a, b, c, d, e, and f are each independently 1-20.
7. The embolic system of claim 5 , wherein the at least one linkage is an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, a peptide cleavable by matrix cathepsins, or a combination thereof.
8. The embolic system of claim 1 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.
9. The embolic system of claim 1 , wherein the crosslinker is bis-glycidyl amino alcohol or bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate.
10. The embolic system of claim 1 , wherein the delivery device is a catheter.
11. The embolic system of claim 1 , wherein the delivery device is a microcatheter.
12. The embolic system of claim 1 , wherein the delivery device is a needle.
13. The embolic system of claim 1 , wherein the delivery device and the embolic solution are sterilized.
14. The embolic system of claim 1 , wherein the embolic solution includes a monomer including an ionizable functional group.
15. The embolic system of claim 14 , wherein the ionizable functional group is basic or acidic.
16. The embolic system of claim 1 , wherein the embolic solution includes a radiopaque contrast agent.
17. The embolic system of claim 1 , wherein the embolic solution includes a dye.
18. The embolic system of claim 1 , wherein the embolic solution is provided in a vial.
19. The embolic system of claim 1 , wherein the embolic solution is provided in a syringe.
20. The embolic system of claim 1 , wherein the polymer particles have a circularity greater than about 0.9.