Heterocycle analogs of CAI-1 as agonists of quorum sensing in vibrio
A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae . Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.
1. A 3-acyl pyrrole compound having one of the structures of the group consisting of:
2. A pharmaceutical composition comprising one or more compounds of claim 1 and a pharmaceutically acceptable carrier, excipient or diluent.
3. A bacterial biofilm-inhibiting composition comprising two or more compounds of claim 1 .
4. A device that is coated or embedded with one or more compounds of claim 1 to prevent bacterial biofilm formation or bacterial transmission.