Methods of modulating cytokine activity; related reagents
Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.
1. A method of treating an immune disorder of asthma or allergy in a subject, comprising administering a therapeutically effective amount of an antibody or antigen binding fragment that specifically binds to IL-33 to the subject in need thereof.
2. The method of claim 1 , wherein the immune disorder comprises a TH2-type response.
3. The method of claim 2 , wherein the TH2-type response comprises an early event in a TH2-type response.
4. The method of claim 1 , wherein the antibody or antigen binding fragment is:
a) a polyclonal antibody;
b) a monoclonal antibody;
c) a humanized antibody, or a fragment thereof; or
d) a Fab, Fv, or F(ab′) 2 fragment.
5. The method of claim 1 , wherein the immune disorder is asthma.
6. The method of claim 1 , wherein the immune disorder is allergy.
7. The method of claim 5 , wherein the asthma comprises a TH2-type response.
8. The method of claim 6 , wherein the allergy comprises a TH2-type response.