Solid forms of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-YL)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one as tor kinase inhibitors

1. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 7.78°, 13.02° and 25.02°±0.2° 2θ.

2. The crystal form of claim 1 , which has an X-ray powder diffraction pattern further comprising peaks at 13.54°, 24.26° and 26.10°±0.2° 2θ.

3. The crystal form of claim 1 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 5%±1% of the total mass of the crystal form when heated from 25° C.±5% °C. to 300° C.±5% °C.

4. The crystal form of claim 1 , which has a single differential thermal analysis thermogram comprising an endotherm between 35° C.±5% °C. and 105° C.±5% °C. with a maximum at 89° C.±5% °C. when heated from 25° C.±5% °C. to 300° C.±5% °C.

5. The crystal form of claim 1 , which is no less than 95% pure.

6. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 7.66°, 10.42° and 27.02°±0.2° 2θ.

7. The crystal form of claim 6 , which has an X-ray powder diffraction pattern further comprising peaks at 14.02°, 17.46° and 24.06°±0.2° 2θ.

8. The crystal form of claim 6 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 5.1%±1% of the total mass of the crystal form when heated from 25° C.±5% °C. to 300° C.±5% °C.

9. The crystal form of claim 1 , which has a single differential thermal analysis thermogram comprising an endotherm between 35° C.±5% °C. and 135° C.±5% °C. with a maximum at 115° C.±5% °C. when heated from 25° C.±5% °C. to 300° C. ±5% °C.

10. The crystal form of claim 9 , wherein the single differential thermal analysis thermogram further comprises an endotherm with a maximum at 177° C.±5% °C.

11. The crystal form of claim 6 , which is no less than 95% pure.

12. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 9.06°, 26.06° and 28.70°±0.2° 2θ.

13. The crystal form of claim 12 , which has an X-ray powder diffraction pattern further comprising peaks at 22.74°, 24.58° and 26.90°±0.2° 2θ.

14. The crystal form of claim 12 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 4.2%±1% of the total mass of the crystal form when heated from 25° C.±5% ° C. to 300° C.±5% °C.

15. The crystal form of claim 12 , which has a single differential thermal analysis thermogram comprising an endotherm between 35° C.±5% °C. and 105° C.±5% °C. with a maximum at 93° C.±5% °C. when heated from 25° C.±5% °C. to 300° C.±5% °C.

16. The crystal form of claim 15 , wherein the single differential thermal analysis thermogram further comprises an endotherm with a maximum at 178.1° C.±5% °C.

17. The crystal form of claim 12 , which is no less than 95% pure.

18. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 13.34°, 22.90° and 25.18°±0.2° 2θ.

19. The crystal form of claim 18 , which has an X-ray powder diffraction pattern further comprising peaks at 7.58°, 12.22° and 24.22°±0.2° 2θ.

20. The crystal form of claim 18 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 1.7%±1% of the total mass of the crystal form when heated from 25° C.±5% ° C. to 300° C.±5% °C.

21. The crystal form of claim 18 , which has a single differential thermal analysis thermogram comprising an endotherm between 110° C.±5% ° C. and 150° C.±5% °C. with a maximum at 101.3° C.±5% °C. when heated from 25° C.±5% °C. to 300° C.±5% °C.

22. The crystal form of claim 21 , wherein the single differential thermal analysis thermogram further comprises an endotherm with a maximum at 141.6° C.±5% °C.

23. The crystal form of claim 18 , which is no less than 95% pure.

24. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 17.42°, 24.70° and 28.34°±0.2° 2θ.

25. The crystal form of claim 24 , which has an X-ray powder diffraction pattern further comprising peaks at 10.82°, 19.30° and 30.86°±0.2° 2θ.

26. The crystal form of claim 24 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 1.6%±1% of the total mass of the crystal form when heated from 25° C.±5% ° C. to 300° C.±5% °C.

27. The crystal form of claim 24 , which has a single differential thermal analysis thermogram comprising an endotherm between 35° C.±5% ° C. and 155° C.±5% °C. with a maximum at 180° C.±5% °C. when heated from 25° C.±5% °C. to 300° C.±5% °C.

28. The crystal form of claim 27 , wherein the single differential thermal analysis thermogram further comprises an endotherm with a maximum at 236° C.±5% °C.

29. The crystal form of claim 24 , which is no less than 95% pure.

30. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 11.50°, 23.42° and 25.06°±0.2° 2θ.

31. The crystal form of claim 30 , which has an X-ray powder diffraction pattern further comprising peaks at 14.90°, 24.18° and 26.10°±0.2° 2θ.

32. The crystal form of claim 30 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 3.8%±1% of the total mass of the crystal form when heated from 25° C.±5% ° C. to 300° C.±5% °C.

33. The crystal form of claim 30 , which has a single differential thermal analysis thermogram comprising an endotherm between 35° C.±5% °C. and 145° C.±5% °C. with a maximum at 89° C.±5% °C. when heated from 25° C. ±5% °C. to 300° C. ±5% °C.

34. The crystal form of claim 33 , wherein the single differential thermal analysis thermogram further comprises an endotherm with a maximum at 200° C.±5% °C.

35. The crystal form of claim 30 , which is no less than 95% pure.

36. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 7.62°, 10.54° and 26.70°±0.2° 2θ.

37. The crystal form of claim 36 , which has an X-ray powder diffraction pattern further comprising peaks at 13.82°, 19.34° and 24.26°±0.2° 2θ.

38. The crystal form of claim 36 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 3.8%±1% of the total mass of the crystal form when heated from 25° C.±5% °C. to 300° C.±5% °C.

39. The crystal form of claim 36 , which has a single differential thermal analysis thermogram comprising an endotherm between 35° C.±5% °C. and 145° C.±5% °C. with a maximum at 108.8° C.±5% °C. when heated from 25° C.±5% °C. to 300° C.±5% °C.

40. The crystal form of claim 39 , wherein the single differential thermal analysis thermogram further comprises an endotherm with a maximum at 164.3° C.±5% °C.

41. The crystal form of claim 36 , which is no less than 95% pure.

42. A crystal form of the compound of formula (I):

which has an X-ray powder diffraction pattern comprising peaks at 6.94°, 13.82° and 27.66°±0.2° 2θ.

43. The crystal form of claim 42 , which has an X-ray powder diffraction pattern further comprising peaks at 22.18°, 26.22° and 26.98°±0.2° 2θ.

44. The crystal form of claim 42 , which has a thermogravimetric analysis thermogram comprising a total mass loss of 4.2%±1% of the total mass of the crystal form when heated from 25° C.±5% °C. to 300° C.±5% °C.

45. The crystal form of claim 42 , which has a single differential thermal analysis thermogram comprising an endotherm between 35° C.±5% °C. and 145° C.±5% °C. with a maximum at 118.7° C.±5% °C. when heated from 25° C.±5% ° C. to 300° C.±5% ° C.

46. The crystal form of claim 42 , which is no less than 95% pure.