IP Library Granted Patent US 9,987,261
Granted Patent B2
US 9,987,261 · App. 15/181,030 · Granted Jun 5, 2018

Substituted diazaspiroalkanes as androgen receptor modulators

Inventors: Michael E. Jung (Los Angeles, CA); Charles L. Sawyers (New York, NY); Samedy Ouk (Los Angeles, CA); Chris Tran (New York, NY); John Wongvipat (New York, NY)
Assignee: The Regents of the University of California
A61K31/4439A61K9/48C07D401/04
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Quick Facts
Patent No.
US 9,987,261
App. No.
15/181,030
Granted
Jun 5, 2018
Kind
B2
Abstract

Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.

Claims (33)

1. A capsule comprising a compound having a formula:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or adjuvant.

2. The capsule of claim 1 , wherein the capsule is coated with gelatin, wax, shellac, or sugar, or a combination thereof.

3. The capsule of claim 1 , wherein the capsule comprises the compound having a formula:

4. The capsule of claim 1 , wherein the capsule comprises the compound having a formula:

5. The capsule of claim 1 , wherein the capsule comprises the compound having a formula:

in a range of from 0.0005 to 500 mg.

6. The capsule of claim 1 , wherein the capsule comprises the compound having a formula:

in a range of from 0.01 to 50 mg.

7. The capsule of claim 1 , wherein the capsule comprises the compound having a formula:

in a range of from 0.05 to 10 mg.

8. A tablet comprising a compound having a formula:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or adjuvant.

9. The tablet of claim 8 , wherein the tablet is coated with gelatin, wax, shellac, or sugar, or a combination thereof.

10. The tablet of claim 8 , wherein the tablet comprises the compound having a formula:

11. The tablet of claim 8 , wherein the tablet comprises the compound having a formula:

12. The tablet of claim 8 , wherein the tablet comprises the compound having a formula:

in a range of from 0.0005 to 500 mg.

13. The tablet of claim 8 , wherein the tablet comprises the compound having a formula:

in a range of from 0.01 to 50 mg.

14. The tablet of claim 8 , wherein the tablet comprises the compound having a formula:

in a range of from 0.05 to 10 mg.

15. A pill comprising a compound having a formula:

or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or adjuvant.

16. The pill of claim 15 , wherein the pill is coated with gelatin, wax, shellac, or sugar, or a combination thereof.

17. The pill of claim 15 , wherein the pill comprises the compound having a formula:

18. The pill of claim 15 , wherein the pill comprises the compound having a formula:

19. The pill of claim 15 , wherein the pill comprises the compound having a formula:

in a range of from 0.0005 to 500 mg.

20. The pill of claim 15 , wherein the pill comprises the compound having a formula:

in a range of from 0.01 to 50 mg.

21. The pill of claim 15 , wherein the pill comprises the compound having a formula:

in a range of from 0.05 to 10 mg.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2018
From: THE HOWARD HUGHES MEDICAL INSTITUTE
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 045527/0069 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2018
From: OUK, SAMEDY; JUNG, MICHAEL E.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 045527/0084 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2018
From: SAWYERS, CHARLES L.; TRAN, CHRISTOPHER T.; WONGVIPAT, JOHN
To: THE HOWARD HUGHES MEDICAL INSTITUTE
Reel/Frame 045932/0815 →
CONFIRMATORY LICENSE Recorded Jan 31, 2017
From: UNIVERSITY OF CALIFORNIA LOS ANGELES
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 041565/0567 →
Continuity (6)
Continuation 14318234 · Jun 27, 2014
Continuation 13615085 · Sep 13, 2012
Continuation 12294881
Provisional Application 60833790 · Jul 28, 2006
Provisional Application 60785978 · Mar 27, 2006
Related Publication 20170014399A1 · Jan 19, 2017