IP Library › Granted Patent US 10,000,489
Granted Patent B2
US 10,000,489 · App. 15/514,407 · Granted Jun 19, 2018

Compounds α

Inventors: Niall Andrew Anderson (Stevenage, GB); Matthew Howard James Campbell-Crawford (Stevenage, GB); Ashley Paul Hancock (Stevenage, GB); John Martin Pritchard (Stevenage, GB); Joanna Mary Redmond (Stevenage, GB)
Assignee: GlaxoSmithKline Intellectual Property Development Limited
C07D471/04
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Quick Facts
Patent No.
US 10,000,489
App. No.
15/514,407
Granted
Jun 19, 2018
Kind
B2
Abstract

A compound of formula (I): wherein R is H or F; or a salt thereof.

Claims (23)

1. A compound of formula (I):

wherein R is H or F;

or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 which is 4-(3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(3-morpholinophenyl)butanoic acid

or a pharmaceutically acceptable salt thereof.

3. The compound according to claim 2 which is (S)-4-((S)-3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(3-morpholinophenyl)butanoic acid

or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 1 which is 4-(3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(2-fluoro-5-morpholinophenyl)butanoic acid

or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 4 which is (S)-4-((S)-3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(2-fluoro-5-morpholinophenyl)butanoic acid

or a pharmaceutically acceptable salt thereof.

6. A method of treating a disorder in a human, wherein the disorder is responsive to antagonism of an α v β 6 receptor and is a fibrotic disease or condition, the method comprising administering to the human in need thereof a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 1 .

7. A method of treating a disorder in a human, wherein the disorder is responsive to antagonism of an α v β 6 receptor and is a fibrotic disease or condition, the method comprising administering to the human in need thereof a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 3 .

8. A method of treating a disorder in a human, wherein the disorder is responsive to antagonism of an α v β 6 receptor and is a fibrotic disease or condition, the method comprising administering to the human in need thereof a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 5 .

9. The method according to claim 6 , wherein the disorder is idiopathic pulmonary fibrosis.

10. The method according to claim 7 , wherein the disorder is idiopathic pulmonary fibrosis.

11. The method according to claim 8 , wherein the disorder is idiopathic pulmonary fibrosis.

12. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 1 , and a pharmaceutically acceptable excipient.

13. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 3 , and a pharmaceutically acceptable excipient.

14. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 5 , and a pharmaceutically acceptable excipient.

15. The pharmaceutical composition according to claim 12 , wherein the pharmaceutical composition is for oral administration.

16. The pharmaceutical composition according to claim 13 , wherein the pharmaceutical composition is for oral administration.

17. The pharmaceutical composition according to claim 14 , wherein the pharmaceutical composition is for oral administration.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2017
From: ANDERSON, NIALL ANDREW; CAMPBELL-CRAWFORD, MATTHEW HOWARD JAMES; HANCOCK, ASHLEY PAUL; PRITCHARD, JOHN MARTIN; REDMOND, JOANNA MARY
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Reel/Frame 044432/0975 →
Priority Claims (1)
GB 1417011.2 · Sep 26, 2014 · national
Continuity (1)
Related Publication 20170298063A1 · Oct 19, 2017