Compounds α
A compound of formula (I): wherein R is H or F; or a salt thereof.
1. A compound of formula (I):
wherein R is H or F;
or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 which is 4-(3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(3-morpholinophenyl)butanoic acid
or a pharmaceutically acceptable salt thereof.
3. The compound according to claim 2 which is (S)-4-((S)-3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(3-morpholinophenyl)butanoic acid
or a pharmaceutically acceptable salt thereof.
4. The compound according to claim 1 which is 4-(3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(2-fluoro-5-morpholinophenyl)butanoic acid
or a pharmaceutically acceptable salt thereof.
5. The compound according to claim 4 which is (S)-4-((S)-3-fluoro-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-3-(2-fluoro-5-morpholinophenyl)butanoic acid
or a pharmaceutically acceptable salt thereof.
6. A method of treating a disorder in a human, wherein the disorder is responsive to antagonism of an α v β 6 receptor and is a fibrotic disease or condition, the method comprising administering to the human in need thereof a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 1 .
7. A method of treating a disorder in a human, wherein the disorder is responsive to antagonism of an α v β 6 receptor and is a fibrotic disease or condition, the method comprising administering to the human in need thereof a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 3 .
8. A method of treating a disorder in a human, wherein the disorder is responsive to antagonism of an α v β 6 receptor and is a fibrotic disease or condition, the method comprising administering to the human in need thereof a therapeutically effective amount of the compound or pharmaceutically acceptable salt according to claim 5 .
9. The method according to claim 6 , wherein the disorder is idiopathic pulmonary fibrosis.
10. The method according to claim 7 , wherein the disorder is idiopathic pulmonary fibrosis.
11. The method according to claim 8 , wherein the disorder is idiopathic pulmonary fibrosis.
12. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 1 , and a pharmaceutically acceptable excipient.
13. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 3 , and a pharmaceutically acceptable excipient.
14. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 5 , and a pharmaceutically acceptable excipient.
15. The pharmaceutical composition according to claim 12 , wherein the pharmaceutical composition is for oral administration.
16. The pharmaceutical composition according to claim 13 , wherein the pharmaceutical composition is for oral administration.
17. The pharmaceutical composition according to claim 14 , wherein the pharmaceutical composition is for oral administration.