X-ray imaging contrast media with low iodine concentration and X-ray imaging process
The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.
1. An X-ray composition comprising Ioforminol and a pharmaceutically acceptable carrier or excipient, wherein the composition comprises an iodine concentration of 40-170 mg I/ml, a sodium ion concentration of 70-120 mM, a calcium ion concentration of 0.5-1.3 mM, and a ratio between the sodium ion and the calcium ion in the range between 110 and 120.
2. A composition as claimed in claim 1 , wherein the iodine concentration is 80-130 mg I/ml, a sodium ion concentration of 88-100 mM, and a calcium ion concentration of 0.7-0.9 mM.
3. A composition as claimed in claim 1 , further comprising potassium and/or magnesium ions.
4. A composition as claimed in claim 1 , wherein the total volume of the composition for administration to a living subject is between 1 and 250 ml.
5. A composition as claimed in claim 1 , wherein the iodine concentration is about 160 mg I/ml, the sodium concentration is about 82 mM, and having a calcium concentration of 0.7 mM.
6. A method of x-ray examination, the method comprising administering the composition of claim 1 to a living subject,
applying an X-ray radiation dose to the living subject,
examining the living subject with a diagnostic device and compiling data from the examination.
7. A method as claimed in claim 6 , wherein said dose of radiation has an average energy spectrum substantially corresponding to the k-edge of iodine.
8. A method as claimed in claim 6 , wherein the X-ray radiation dose is provided by a tube voltage energy in the range of 70-140 kVp.
9. A method as claimed in claim 6 , wherein the X-ray radiation dose is provided by a tube current in the range of 5-1000 mA.
10. A method as claimed in claim 6 , further including a step of noise reduction through an advanced image reconstruction method.
11. A method as claimed in claim 6 , wherein the noise reduction is selected from the iterative image reconstruction methods ASiR and MBIR.
12. A method as claimed in claim 6 , including Dual Energy CT.
13. A method of x-ray examination, the method comprising administering an X-ray composition to a living subject,
wherein the composition comprising Ioforminol having an iodine concentration of 80-130 mg I/ml, a sodium ion concentration of 88-100 mM, and a calcium ion concentration of 0.7-0.9 mM, a ratio between the sodium ion and the calcium ion in the range between 110 and 120, and a pharmaceutically acceptable carrier or excipient, the method comprising,
applying an X-ray radiation dose to the living subject,
examining the living subject with a diagnostic device and compiling data from the examination,
wherein said dose of radiation has an average energy spectrum substantially corresponding to the k-edge of iodine.
14. A method as claimed in claim 13 , wherein the X-ray radiation dose is provided by a tube voltage energy in the range of 70-140 kVp.
15. A method as claimed in claim 13 , wherein the X-ray radiation dose is provided by a tube current in the range of 5-500 mA.
16. A method as claimed in claim 13 , further including a step of noise reduction through an advanced image reconstruction method.
17. A method as claimed in claim 13 , wherein the noise reduction is selected from the iterative image reconstruction methods ASiR and MBIR.
18. A method as claimed in claim 13 , including Dual Energy CT.
19. A method as claimed in claim 13 , wherein the X-ray radiation dose is provided by a tube voltage energy in the range of about 80 kVp and the volume of the composition is about 1.5 mL/kg of the living subject.