IP Library Granted Patent US 10,015,980
Granted Patent B2
US 10,015,980 · App. 14/060,494 · Granted Jul 10, 2018

Methods and formulations promoting tissue/organ regeneration, longevity and healthspan

Inventors: Valter D. Longo (Playa del Rey, CA); Chia-Wei Cheng (Los Angeles, CA); Sebastian Brandhorst (Redondo Beach, CA); Min Wei (West Covina, CA)
Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
A23L33/40A23L29/37A23L33/115A23L33/15A23L33/155A23L33/16A23L33/17A23L33/175A23L33/30A61K45/00A23V2002/00
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Quick Facts
Patent No.
US 10,015,980
App. No.
14/060,494
Granted
Jul 10, 2018
Kind
B2
Abstract

A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. The first diet includes less than 30 g of sugar on the first day; less than 20 g of sugar on the second to fifth days; less than 28 g of proteins on the first day; less than 18 g of proteins on days the second to fifth days; 20 to 30 grams of monounsaturated fats on the first day; 10 to 15 grams of monounsaturated fats on the second to fifth days; and between 6 and 10 grams of polyunsaturated fats on the first day.

Claims (3)

1. A method for improving age-dependent working memory deficits and short term spatial memory, the method comprising:

administering an amino acid specific diet supplement for a time period of about 5 days to 14 days, the amino acid specific diet supplement comprising the following amino acids as a source of nitrogen: alanine, aspartic acid, cysteine, glutamic acid, glycine, histidine, proline, serine, and tyrosine while substantially excluding isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, and arginine such that isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, and arginine which in combination are administered in an amount that is less than 5% of a total weight of a subject's diet.

2. The method of claim 1 wherein isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, and arginine in combination are present in an amount that is less than 3% of a total weight of a subject's diet.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 23, 2015
From: UNIVERSITY OF SOUTHERN CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035258/0565 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2013
From: LONGO, VALTER D.; CHENG, CHIA-WEI; BRANDHORST, SEBASTIAN; WEI, MIN
To: UNIVERSITY OF SOUTHERN CALIFORNIA
Reel/Frame 031770/0138 →
Continuity (4)
Provisional Application 61746787 · Dec 28, 2012
Provisional Application 61736308 · Dec 12, 2012
Provisional Application 61716676 · Oct 22, 2012
Related Publication 20140112909A1 · Apr 24, 2014
Cited By (3)
US 12,185,747 US 12,186,352 US 12,616,232