3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof

1. A compound of Formula (1):

or a pharmaceutically acceptable salt thereof,

wherein

X is an oxygen atom or a sulfur atom;

Y is —CO—, —CS—, —SO—, or —SO 2 —;

R 1 is, a halogen atom, a cyano group, a nitro group, a substituted C 1-6 alkyl group, an optionally-substituted C 1-6 alkoxy group, an optionally-substituted C 1-6 alkylcarbonyl group, an optionally substituted C 3-10 cycloalkyl group, an optionally-substituted C 3-10 cycloalkylcarbonyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally substituted 3- to 8-membered saturated heterocyclic carbonyl group, an optionally-substituted C 6-10 arylcarbonyl group, or an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroarylcarbonyl group;

R 2 is, an optionally-substituted C 1-6 alkyl group, an optionally-substituted C 1-6 alkoxy group, an optionally-substituted amino group, an optionally-substituted C 3-10 cycloalkyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally-substituted C 6-10 aryl group, or an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group;

R 3 , R 4 , R 5 , and R 6 are independently a hydrogen atom, a halogen atom, a cyano group, a nitro group, a hydroxy group, an optionally-substituted C 1-6 alkyl group, an optionally substituted C 2-6 alkenyl group, an optionally-substituted C 2-6 alkynyl group, an optionally substituted C 1-6 alkoxy group, an optionally-substituted C 1-6 alkylthio group, an optionally substituted C 6-10 arylthio group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroarylthio group, an optionally-substituted C 1-6 alkylsulfinyl group, an optionally-substituted C 6-10 arylsulfinyl group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroarylsulfinyl group, an optionally-substituted C 1-6 alkylsulfonyl group, an optionally-substituted C 6-10 arylsulfonyl group, an optionally substituted 5- to 12-membered monocyclic or polycyclic heteroarylsulfonyl group, an optionally-substituted amino group, an optionally-substituted C 1-6 alkylcarbonyl group, an optionally-substituted C 3-10 cycloalkyl group, an optionally-substituted C 3-10 cycloalkenyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally-substituted C 6-10 aryl group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group, a C 1-6 alkylsulfinyl group, an optionally substituted C 3-10 cycloalkylsulfinyl group, an optionally-substituted C 1-6 alkylsulfonyl group, or an optionally-substituted C 3-10 cycloalkylsulfonyl group; and

R 7 is a hydrogen atom, an optionally-substituted C 1-6 alkyl group, an optionally substituted C 1-6 alkylcarbonyl group, an optionally-substituted C 3-10 cycloalkyl group, an optionally-substituted 3- to 8-membered saturated heterocyclic group, an optionally substituted C 6-10 aryl group, or an optionally-substituted 5- to 12-membered monocyclic or polycyclic heteroaryl group;

provided that the following compounds are excluded:

the compounds wherein Y is —CO— and R 1 is a methyl group,

3-(furan-2-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

3-(2-naphthoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

ethyl 4,9-dioxo-2-(trifluoromethyl)-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate,

3-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

3-isonicotinoyl-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

3-(benzo[d][1,3]dioxole-5-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

3-(4-methoxybenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

3-(3,4-dimethoxybenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

3-benzoyl-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

3-(4-bromobenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

2-(trifluoromethyl)-3-(3,4,5-trimethoxybenzoyl)naphtho[2,3-b]furan-4,9-dione,

3-(4-fluorobenzoyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione, and

3-(thiophene-2-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione.

2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein X is an oxygen atom.

3. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein Y is —CO— or —SO 2 —.

4. The compound of claim 3 or a pharmaceutically acceptable salt thereof, wherein Y is —CO—.

5. The compound of claim 3 or a pharmaceutically acceptable salt thereof, wherein Y is —SO 2 —.

6. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is a substituted C 1-6 alkyl group or an optionally-substituted C 1-6 alkylcarbonyl group.

7. The compound of claim 6 or a pharmaceutically acceptable salt thereof, wherein R 1 is:

(1) a C 1-6 alkyl group substituted with (a) 1 to 3 halogen atoms, (b) a hydroxy group, (c) 1 to 2 C 1-4 alkoxy groups, or (d) a 4- to 7-membered cyclic amino group, or

(2) a C 1-6 alkylcarbonyl group optionally substituted with (a) 1 to 3 halogen atoms, (b) a hydroxy group, (c) 1 to 2 C 1-4 alkoxy groups, or (d) a 4- to 7-membered cyclic amino group.

8. The compound of claim 7 or a pharmaceutically acceptable salt thereof, wherein R 1 is:

(1) a C 1-6 alkyl group substituted with (a) 1 to 3 halogen atoms, or (b) a hydroxy group, or

(2) a C 1-6 alkylcarbonyl group.

9. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 2 is an optionally-substituted C 1-6 alkyl group, an optionally-substituted C 1-6 alkoxy group, an optionally-substituted amino group, an optionally-substituted C 6-10 aryl group, or an optionally-substituted 3- to 8-membered saturated heterocyclic group.

10. The compound of claim 9 or a pharmaceutically acceptable salt thereof, wherein R 2 is:

(1) an optionally-substituted C 1-6 alkyl group,

(2) a C 1-6 alkoxy group,

(3) an amino group optionally substituted with 1 to 2 C 1-6 alkyl groups,

(4) a 4- to 7-membered cyclic amino group optionally substituted with (a) 1 to 3 halogen atoms, (b) a hydroxy group, (c) a C 1-4 alkylsulfonyl group, (d) a C 1-4 alkyl group optionally substituted with a carboxy group or a 4- to 7-membered cyclic amino group, (e) 1 to 3 C 1-4 alkoxy groups, or (f) a 4- to 7-membered cyclic amino group,

(5) a C 6-10 aryl group optionally substituted with (a) 1 to 3 halogen atoms, (b) a hydroxy group, (c) a carboxy group, (d) a cyano group, (e) a C 1-4 alkylsulfonyl group, (f) a C 1-4 alkyl group optionally substituted with a carboxy group or a 4- to 7-membered cyclic amino group, (g) 1 to 3 C 1-4 alkoxy groups, or (h) a 4- to 7-membered cyclic amino group, or

(6) a 3- to 8-membered saturated heterocyclic group optionally substituted with (a) 1 to 3 halogen atoms, (b) a hydroxy group, (c) a carboxy group, (d) a C 1-4 alkylsulfonyl group, (e) a C 1-4 alkyl group optionally substituted with a carboxy group or a 4- to 7-membered cyclic amino group, (f) 1 to 3 C 1-4 alkoxy groups, or (g) a 4- to 7-membered cyclic amino group.

11. The compound of claim 10 or a pharmaceutically acceptable salt thereof, wherein R 2 is:

(1) a C 1-6 alkyl group optionally substituted with an optionally-substituted 4- to 7-membered cyclic amino group, or a mono- or di-substituted amino group,

(2) an amino group optionally substituted with a C 1-6 alkyl group, or

(3) a 4- to 7-membered cyclic amino group optionally substituted with 1 to 2 C 1-6 alkyl groups.

12. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 3 , R 4 , R 5 , and R 6 are independently a hydrogen atom, a halogen atom, a hydroxy group, or a C 1-6 alkoxy group.

13. The compound of claim 12 or a pharmaceutically acceptable salt thereof, wherein R 3 , R 4 , R 5 , and R 6 are a hydrogen atom.

14. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the compound is chosen from:

methyl 2-(1,1-dimethoxyethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate,

methyl 2-acetyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate,

2-acetyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylic acid,

2-acetyl-N,N-dimethyl-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide,

2-acetyl-3-(4-methylpiperazine-1-carbonyl)naphtho[2,3-b]furan-4,9-dione hydrochloride,

methyl 4,9-dioxo-2-(trifluoromethyl)-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate,

4,9-dioxo-2-(trifluoromethyl)-4,9-dihydronaphtho[2,3-b]furan-3-carboxylic acid,

3-(4-methylpiperazine-1-carbonyl)-2-(trifluoromethyl)naphtho[2,3-b]furan-4,9-dione,

2-(1,1-dimethoxyethyl)-3-(morpholine-4-carbonyl)naphtho[2,3-b]furan-4,9-dione,

2-acetyl-3-(morpholine-4-carbonyl)naphtho[2,3-b]furan-4,9-dione,

methyl 2-(chloromethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate,

methyl 2-(morpholinomethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxylate,

2-(1,1-dimethoxyethyl)-3-((4-methylpiperazine-1-yl)sulfonyl)naphtho[2,3-b]furan-4,9-dione,

2-acetyl-3-((4-methylpiperazine-1-yl)sulfonyl)naphtho[2,3-b]furan-4,9-dione,

2-(1,1-dimethoxyethyl)-3-(phenylsulfonyl)naphtho[2,3-b]furan-4,9-dione,

2-acetyl-3-(phenylsulfonyl)naphtho[2,3-b]furan-4,9-dione, and

N,N-dimethyl-4,9-dioxo-2-(trifluoromethyl)-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide.

15. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof.

16. A method for treating cancer comprising administering an effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the cancer is chosen from hematological cancer, myeloma, liver cancer, ovarian cancer, prostate cancer, lung cancer, osteosarcoma, colon cancer, breast cancer, skin cancer, and epithelial cell cancer.

17. The compound of claim 1 or a pharmaceutically acceptable salt thereof for use in preventing or treating cancer, wherein the cancer is chosen from hematological cancer, myeloma, liver cancer, ovarian cancer, prostate cancer, lung cancer, osteosarcoma, colon cancer, breast cancer, skin cancer, and epithelial cell cancer.