Biochip including side emitting-type light-emitting device and fabrication method thereof
The present disclosure a biochip including a side emitting-type light-emitting device, in which the bio-chip includes: a light-emitting device for emitting light from a fluorescent material; reflective layers provided over and under the light-emitting device so as to emit light from the sides of the light-emitting device; and reaction regions formed by etching of flanking regions of the light-emitting device. In the biochip, light emitted from the sides of the light-emitting device causes a biochemical reaction in the reaction regions. According to the present disclosure, light emitted from the light-emitting device moves only laterally without being transferred to the top or bottom of the bio-layer, and is transferred to the reaction regions formed by etching of flanking regions of the light-emitting device, so that a biochemical reaction in the reaction regions can be more efficiently performed.
1. A biochip comprising:
a bio-layer comprising therein:
a plurality of reaction regions in which a biochemical reaction between a reference sample and a target sample occurs, and
a plurality of light-emitting devices, wherein the plurality of light-emitting devices each comprises a light-emitting region, a first reflective layer below the light-emitting region, and a second reflective layer above the light-emitting region, wherein the first reflective layer and the second reflective layer function as blocking layers to prevent light from the light-emitting region from being emitted from a top surface of the bio-layer or a bottom surface of the bio-layer such that light from the light-emitting region may only be transmitted laterally within the bio-layer, wherein each of the plurality of light-emitting devices is adjacent to at least one of the plurality of reaction regions such that the light transmitted from the plurality of light-emitting devices is received by the at least one of the plurality of reaction regions; and
an image sensor layer formed under the bio-layer and having formed therein a plurality of photodetectors for detecting light from at least one of the plurality of reaction regions,
wherein each of the plurality of reaction regions receives light transmitted from at least two light-emitting devices of the plurality of light-emitting devices through respective sides of the at least two light-emitting devices, and
wherein the reference sample is uniformly spread in each of the plurality of reaction regions between a top of the bio-layer, a bottom of the bio-layer, and the respective sides of the at least two light-emitting devices.
2. The biochip of claim 1 , wherein the plurality of reaction regions is formed by dry- or wet-etching so as to extend from top to bottom of the bio-layer.
3. The biochip of claim 1 , wherein the plurality of reaction regions is formed by a multi-step etching process so as to have a stepped portion.
4. The biochip of claim 1 , wherein the plurality of reaction regions is formed by slope etching so as to have a slanted shape.
5. The biochip of claim 1 , wherein the plurality of reaction regions is formed by etching so as to have a rectangular or round shape.
6. The biochip of claim 1 , further comprising a filter layer between the bio-layer and the image sensor layer.