Dental implant and method for producing same
The object of the present invention is to provide an implant that enables functional periodontium formation around the implant after transplantation of a dental implant. In some aspects of the present invention, a tooth germ tissue-derived or a periodontal membrane tissue-derived cell mass is placed on the surface of the implant, and the surface of the implant on which the cell mass is placed is the whole or a part of the surface which is surrounded by the alveolar bone of the recipient at the time of implant transplantation.
1. A dental implant that enables functional periodontium formation,
comprising a physically cut tissue resected from a dental follicle placed on a surface of the dental implant,
wherein the physically cut tissue resected from the dental follicle is a cell mass that at least partially maintains the functional binding between cells that form the tissue and retains a form that allows discrimination between the exterior and the interior of the tissue and only the interior of the tissue is placed in contact with the surface of the dental implant; and
at the time of transplantation the dental implant retains the physically cut tissue on its surface and the surface of said implant on which said resected tissue is placed is the whole or a part of the surface which is surrounded by alveolar bone of a recipient.
2. The implant according to claim 1 , wherein the dental implant is correctable after implant transplantation.
3. The implant according to claim 1 , wherein said periodontium formed has at least one characteristic among:
(i) having functional cementum and functional periodontal membrane, and
(ii) having functional nerve fiber.
4. The implant according to claim 1 , wherein said implant further comprises a coating layer of a surface coating agent on the entire surface of the implant or a part thereof, and said physically cut tissue resected from the dental follicle is placed on the surface of said coating layer.
5. The implant according to claim 4 , wherein said surface coating agent is selected from the group consisting of hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate, and collagen.
6. The dental implant of claim 1 , wherein the physically cut tissue is resected in a form of strips that are placed on the dental implant surface without overlapping.
7. A method for manufacturing a dental implant that enables the formation of functional periodontium, the method comprising:
placing a physically cut tissue resected from a dental follicle on an entire surface of a dental implant or a part thereof,
wherein the physically cut tissue resected from the dental follicle is a cell mass that at least partially maintains the functional binding between cells that form the tissue and retains a form that allows discrimination between the exterior and the interior of the physically cut tissue such that the interior of the tissue is placed in contact with the surface of the dental implant, the implant surface or a part thereof is surrounded by alveolar bone of a recipient at the time of transplantation of said implant, and the dental implant with the physically cut tissue retains the physically cut tissue at the time of transplantation.
8. The method for manufacturing an implant according to claim 7 , wherein said implant is correctable after transplantation of said implant.
9. The method for manufacturing an implant according to claim 7 , wherein said periodontium formed has at least one characteristic among:
(i) having functional cementum and functional periodontal membrane, and
(ii) having functional nerve fiber.
10. The method for manufacturing an implant according to claim 7 , wherein the method further comprises, before the step of placing said physically cut tissue resected from the dental follicle, forming a coating layer comprising a surface coating agent on the entire surface of the implant or a part thereof, and
wherein said physically cut tissue is placed on the surface of said coating layer.
11. The method for manufacturing an implant according to claim 10 , wherein said surface coating agent is selected from the group consisting of hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate, and collagen.
12. The method of claim 7 , wherein the physically cut tissue is resected in a form of strips that are placed on the dental implant surface without overlapping.
13. A method for transplanting a dental implant in an animal that has lost a tooth, comprising:
transplanting at a site of tooth loss a dental implant that enables functional periodontium formation, the dental implant comprising:
a physically cut tissue resected from a dental follicle placed on a surface of the dental implant, wherein the physically cut tissue resected from the dental follicle is a cell mass that at least partially maintains the functional binding between cells that form the tissue and retains a form that allows discrimination between the exterior and the interior of the tissue such that the interior of the tissue is placed in contact with the surface of the dental implant;
the surface of said implant on which said resected tissue is placed is the whole or a part of the surface which is surrounded by alveolar bone of a recipient at the time of transplantation of said implant; and
the dental implant is transplanted with the physically cut tissue on its surface.
14. The method for transplanting an implant according to claim 13 , wherein said animal is a non-human mammal.
15. The method for transplanting an implant according to claim 13 , wherein said animal is a human.
16. The method of claim 13 , wherein the physically cut tissue is resected in a form of strips that are placed on the dental implant surface without overlapping.