IP Library › Granted Patent US 10,023,574
Granted Patent B2
US 10,023,574 · App. 15/801,442 · Granted Jul 17, 2018

8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions

Inventors: Frank Himmelsbach (Mittelbiberach, DE); Elke Langkopf (Biberach an der Riss, DE); Matthias Eckhardt (Biberach an der Riss, DE); Roland Maier (Biberach an der Riss, DE)
Assignee: Boehringer Ingelheim International GmbH
C07D473/04C07D473/06C07D473/08C07D519/00
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Quick Facts
Patent No.
US 10,023,574
App. No.
15/801,442
Granted
Jul 17, 2018
Kind
B2
Abstract

The present invention relates to substituted xanthines of general formula wherein R 1 to R 3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).

Claims (2)

1. 3-Methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine.

2. 3-Methyl-7-(2-butyn-1-yl)-8-bromo-xanthine.

Priority Claims (2)
DE 10238243 · Aug 21, 2002 · national
DE 10312353 · Mar 20, 2003 · national
Continuity (10)
Continuation 15366019 · Dec 1, 2016
Continuation 15070263 · Mar 15, 2016
Continuation 14748792 · Jun 24, 2015
Continuation 14154885 · Jan 14, 2014
Continuation 13448495 · Apr 17, 2012
Continuation 12143128 · Jun 20, 2008
Continuation 10639036 · Aug 12, 2003
Provisional Application 60461752 · Apr 10, 2003
Provisional Application 60409312 · Sep 9, 2002
Related Publication 20180057495A1 · Mar 1, 2018
Cited By (2)
US 12,312,352 US 12,364,700