Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors

1. A compound of Formula (I):

or a salt thereof; wherein:

Q 1 is:

(i) Cl, I, —CN, —CH 3 , or —CF 3 ; or

(ii) pyrazolyl, triazolyl, or pyridinyl, each substituted with R 1 ;

R 1 is C 1-3 alkyl, C 1-3 fluoroalkyl, C 3-6 cycloalkyl, —NHC(O)(C 1-3 alkyl), or tetrahydropyranyl;

Q 2 is morpholinyl, piperidinyl, pyridinyl, indazolyl, isoquinolinyl, or benzo[d]imidazolyl, each substituted with R 2 and R 3 ;

R 2 is H, F, Cl, Br, C 1-3 alkyl, C 1-3 fluoroalkyl, —C(O)(pyrrolidinyl), —C(O)NR a R a , —CH 2 C(O)NR a R a , —C(O)NR a (C 4-6 cycloalkyl), —C(O)NR a (phenyl), C 1-3 hydroxy-fluoroalkyl, —CH 2 (C 3-6 cycloalkyl), —CH 2 (C 3-6 fluorocycloalkyl), ═O, R x , or —CH 2 R x ;

R x is isoxazolyl, pyrrolidinonyl, tetrahydropyranyl, thiopyran 1,1-dioxide, morpholinyl, morpholinonyl, thiomorpholine 1,1-dioxide, pyridinonyl, phenyl, piperazinyl, piperazinonyl, or piperidinyl, each substituted with zero to 5 substituents independently selected from C 1-3 alkyl, —C(O)NR a R a , —C(O)(C 1-3 alkyl), —C(O)(C 1-3 hydroxyalkyl), —C(O)(C 3-6 cycloalkyl), —C(O)CH 2 O(C 1-3 alkyl), —NHC(O)(C 1-3 alkyl), —S(O) 2 (C 1-3 alkyl), and oxetanyl;

R 3 is H, F, or —CH 3 ;

R 4 is H or F; and

each R a is independently H or C 1-3 alkyl.

2. The compound according to claim 1 or a salt thereof; wherein:

R 1 is —CH 3 , —CH(CH 3 ) 2 , —CH 2 CF 3 , —CH(CH 3 )CF 3 , cyclopropyl, cyclohexyl, —NHC(O)CH 3 , or tetrahydropyranyl; and

R 2 is H, Br, —CH 3 , —CH(CH 3 ) 2 , —CH 2 CH 2 F, —CH 2 C(O)N(CH 3 ) 2 , —CH 2 CH(OH)CH 2 F, —CH 2 (cyclopropyl), —CH 2 (difluorocyclopropyl), —CH 2 (methyl isoxazolyl), —CH 2 (pyrrolidinonyl), ═O, tetrahydropyranyl, dimethyl tetrahydropyranyl, thiopyran 1,1-dioxide, morpholinyl, thiomorpholine 1,1-dioxide, methyl pyridinonyl, phenyl substituted with —C(O)NH 2 , NHC(O)CH 3 , or —S(O) 2 CH 3 ; piperazinyl or piperazinonyl, each substituted with zero to 5 substituents independently selected from —CH 3 , —C(O)CH 3 , —C(O)(cyclopropyl), and oxetanyl; or piperidinyl or piperidinonyl, each substituted with —CH 3 , —C(O)CH 3 , —C(O)CH 2 OH, or —C(O)CH 2 OCH 3 .

3. The compound according to claim 1 or a salt thereof, wherein Q 2 is:

4. The compound according to claim 1 or a salt thereof, wherein:

Q 1 is Cl, I, —CN, or —CF 3 .

5. The compound according to claim 1 or a salt thereof, wherein:

Q 1 is pyrazolyl, triazolyl, or pyridinyl, each substituted with R 1 .

6. The compound according to claim 1 or a salt thereof, wherein Q 2 is:

7. The compound according to claim 1 or a salt thereof, wherein said compound is selected from 1-(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)piperazin-1-yl)ethanone, TFA (1); 5-(4-amino-5-(1-cyclohexyl-1H-pyrazol-5-yl)pyrrolo[2,1-J][1,2,4]triazin-7-yl)-1H-benzo[d]imidazol-2(3H)-one (2); 5-(1-cyclohexyl-1H-pyrazol-5-yl)-7-(1-methyl-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (3); 1-(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)piperazin-1-yl)ethanone, TFA (4); 1-(4-(5-(4-amino-5-(1-isopropyl-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)piperazin-1-yl)ethanone, TFA (5); 4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)thiomorpholine 1,1-dioxide (6); 4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)thiomorpholine 1,1-dioxide (7); 4-(5-(4-amino-5-(1-isopropyl-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)thiomorpholine 1,1-dioxide (8); 1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-2,6-dimethylpiperazin-1-yl)ethanone (9); 1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-2,6-dimethylpiperazin-1-yl)ethanone (10); 1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,5-dimethylpiperazin-1-yl)ethanone (11); 1-((cis)-4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,5-dimethylpiperazin-1-yl) ethanone (12); 1-((cis)-4-(5-(4-amino-5-(1-isopropyl-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,5-dimethylpiperazin-1-yl)ethanone (13); 1-(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl) pyridin-3-yl)-2,3,5,6-tetramethylpiperazin-1-yl)ethanone (14); 1-(4-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-2,3,5,6-tetramethylpiperazin-1-yl)ethanone (15); 7-(1-(tetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (16); 7-(1-(2-fluoroethyl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-4-amine (17); 5-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)-1-methylpyridin-2(1H)-one (18); 5-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)-1-methylpiperidin-2-one (19); 1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)piperidin-1-yl)ethanone (20); 1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl) piperidin-1-yl)ethanone (21); 1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methyl-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)-2-hydroxyethanone (22); 1-(4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methyl-1H-benzo[d]imidazol-1-yl) piperidin-1-yl)-2-methoxyethanone (23); 5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (24); 5-(1-isopropyl-1H-1,2,3-triazol-5-yl)-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (25); 5-(1-cyclohexyl-1H-1,2,3-triazol-5-yl)-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (26); 7-(1-(2,6-dimethyltetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (27); 7-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-4-amine (28); 7-(3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (29); 7-(1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (30); 5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (31); 5-(1-cyclohexyl-1H-1,2,3-triazol-5-yl)-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (32); 4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (33); 4-(6-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (34); 4-(6-(4-amino-5-(1-cyclohexyl-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl) tetrahydro-2H-thiopyran 1,1-dioxide (35); 4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-4-fluoro-1H-indazol-1-yl) tetrahydro-2H-thiopyran 1,1-dioxide (36); 4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-7-yl)-4-fluoro-1H-indazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (37); 4-(6-(4-amino-5-(1-cyclopropyl-1H-pyrazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-7-yl)-4-fluoro-1H-indazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (38); 4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-benzo[d]imidazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (39); 4-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-benzo[d]imidazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (40); 4-(6-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-benzo[d]imidazol-1-yl)tetrahydro-2H-thiopyran 1,1-dioxide (41); 7-(1-isopropyl-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (42); 7-(1-(cyclopropylmethyl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (43); 7-(1-(cyclopropylmethyl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (44); 7-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (45); 7-(1-(cyclopropylmethyl)-1H-benzo[d]imidazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (46); 7-(1-((2,2-difluorocyclopropyl) methyl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-4-amine (47); 7-(1-((2,2-difluorocyclopropyl) methyl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (48); 1-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)-3-fluoropropan-2-ol (49); 1-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)-3-fluoropropan-2-ol (50); 2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)-N,N-dimethylacetamide (51); (R)-5-((6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)methyl)pyrrolidin-2-one (52); 7-(1-((5-methylisoxazol-3-yl)methyl)-1H-indazol-6-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (54); 2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)benzamide (55); N-(2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)phenyl)acetamide (56); 3-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-indazol-1-yl)benzamide (57); 1-(4-(7-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl) isoquinolin-1-yl)piperazin-1-yl)ethanone (58); 7-(1-morpholinoisoquinolin-7-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (59); 4-(7-(4-amino-5-(1-isopropyl-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl) isoquinolin-1-yl)thiomorpholine 1,1-dioxide (60); 4-(7-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)isoquinolin-1-yl) thiomorpholine 1,1-dioxide (61); 7-(2-(piperazin-1-yl)pyridin-4-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (62); 7-(2-(4-(oxetan-3-yl)piperazin-1-yl)pyridin-4-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-4-amine (63); 7-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (64); 1-(4-(4-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)piperazin-1-yl)ethanone (65); 2-(4-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)benzamide (66); 2-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)benzamide (67); 7-(2-(2-(methylsulfonyl)phenyl)pyridin-4-yl)-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (68); 7-[1-(oxan-4-yl)-1H-indazol-6-yl]-5-[1-(propan-2-yl)-1H-pyrazol-4-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine (69); 4-(6-{4-amino-5-[1-(propan-2-yl)-1H-pyrazol-4-yl]pyrrolo[2,1-f]-9-[1,2,4]triazin-7-yl}-1H-indazol-1-yl)-1λ 6 -thiane-1,1-dione (70); 5-(1-methyl-1H-pyrazol-4-yl)-7-[1-(oxan-4-yl)-1H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine (71); 7-(1H-indazol-6-yl)-5-[1-(oxan-4-yl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine (72); 4-amino-7-[1-(oxan-4-yl)-1H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile (73); 4-{6-[4-amino-5-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-1H-indazol-1-yl}-1λ 6 -thiane-1,1-dione (74); 5-iodo-7-[1-(oxan-4-yl)-1H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine (75); 5-chloro-7-[1-(oxan-4-yl)-1H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine (76); N-(5-{4-amino-7-[1-(oxan-4-yl)-1H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}pyridin-2-yl)acetamide (78); N-(5-{4-amino-7-[1-(1,1-dioxo-1λ 6 -thian-4-yl)-1H-indazol-6-yl]pyrrolo[2,1-f][1,2,4]triazin-5-yl}pyridin-2-yl)acetamide (79); 2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-benzo[d]imidazol-1-yl)benzamide (80); 2-(6-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,3-triazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-1H-benzo[d]imidazol-1-yl)benzamide (81); 7-(5-bromopyridin-3-yl)-5-[1-(oxan-4-yl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine (82); 4-acetyl-1-(5-(4-amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,3-dimethylpiperazin-2-one (83); 4-acetyl-1-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,3-dimethylpiperazin-2-one (84); (R)-4-acetyl-1-(4-(4-amino-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3-dimethylpiperazin-2-one (85); 1-(5-(4-amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl) pyridin-3-yl)-4-(cyclopropanecarbonyl)-3,3-dimethylpiperazin-2-one (86); 1-(5-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-4-(cyclopropanecarbonyl)-3,3-dimethylpiperazin-2-one (87); 4-acetyl-1-(5-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,3-dimethylpiperazin-2-one (88); 1-(5-(4-amino-5-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-4-(cyclopropanecarbonyl)-3,3-dimethylpiperazin-2-one (89); (R)-1-(4-(4-amino-5-(1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-4-(cyclopropanecarbonyl)-3,3-dimethylpiperazin-2-one (90); (S)-4-acetyl-1-(5-(4-amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,3,6-trimethylpiperazin-2-one (91); (S)-4-acetyl-1-(5-(4-amino-5-(trifluoromethyl)pyrrolo [2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,3,6-trimethylpiperazin-2-one (92); (S)-4-acetyl-1-(4-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (93); (S)-4-acetyl-1-(4-(4-amino-5-(1-methyl-1H-pyrazol-4-yl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (94); (R)-4-(5-(4-amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,6-trimethylmorpholin-3-one (95); S)-4-acetyl-1-(4-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (96); (R)-4-(5-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,5-trimethylmorpholin-3-one (97); (S)-4-acetyl-1-(4-(4-amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (98); (S)-4-(5-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,5-trimethylmorpholin-3-one (99); (R)-4-(5-(4-amino-5-chloro-6-fluoropyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,5-trimethylmorpholin-3-one (100); (R)-4-(5-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,5-trimethylmorpholin-3-one (101); (S)-4-acetyl-1-(5-(4-amino-5-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-3-yl)-3,3,6-trimethylpiperazin-2-one (102); (S)-4-(5-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,6-trimethylmorpholin-3-one (103); ((S)-4-acetyl-1-(5-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl) pyridin-3-yl)-3,3,6-trimethylpiperazin-2-one (104); (S)-4-(5-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,5-trimethylmorpholin-3-one (105); (S)-4-acetyl-1-(6-(4-amino-5-chloropyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (106); (S)-4-(5-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-methylpyridin-3-yl)-2,2,6-trimethylmorpholin-3-one (107); (S)-4-acetyl-1-(6-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo [2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (108); (S)-7-(6-(4-acetyl-3,3,6-trimethyl-2-oxopiperazin-1-yl)pyridin-2-yl)-4-aminopyrrolo[2,1-f][1,2,4]triazine-5-carbonitrile (109); (S)-4-acetyl-1-(6-(4-amino-5-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (110); (S)-4-acetyl-1-(6-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)pyridin-2-yl)-3,3,6-trimethylpiperazin-2-one (111); (S)-4-(4-(4-amino-5-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl) pyridin-2-yl)-2,2,5-trimethylmorpholin-3-one (112); (4-(4-amino-5-(trifluoromethyl) pyrrolo[2,1-f][1,2,4]triazin-7-yl)morpholin-2-yl)(pyrrolidin-1-yl)methanone (113); 4-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-isopropylmorpholine-2-carboxamide (114); 4-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-cyclohexylmorpholine-2-carboxamide (115); 1-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-cyclopentylpiperidine-3-carboxamide (116); 1-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-N,N-dimethylpiperidine-3-carboxamide (117); 1-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-phenylpiperidine-3-carboxamide (118); and 1-(4-amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl)-N-isopropylpiperidine-3-carboxamide (119).

8. A pharmaceutical composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier or diluent.

9. A method of treating a disease, comprising administering to a patient a therapeutically-effective amount of a compound according to claim 1 , wherein the disease is inflammatory or autoimmune disease.

10. The method according to claim 9 , wherein said autoimmune disease or chronic inflammatory disease is systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, multiple vasculitides, idiopathic thrombocytopenic purpura, myasthenia gravis, allergic rhinitis, or multiple sclerosis.