IP Library Granted Patent US 10,034,633
Granted Patent B2
US 10,034,633 · App. 14/632,982 · Granted Jul 31, 2018

Neuroparticle with a spin-torque device

Inventors: Irving N. Weinberg (Bethesda, MD); Edo Waks (Washington, DC); Benjamin Shapiro (Washington, DC)
Assignees: WEINBERG MEDICAL PHYSICS INC.; UNIVERSITY OF MARYLAND COLLEGE PARK
A61B5/4041A61B5/0515H02J7/025H02J50/00H02J50/10A61B5/065A61B5/6877A61B18/1206A61B2018/00613A61B2560/0219A61B2562/0285A61N1/36014A61N2005/1098
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Quick Facts
Patent No.
US 10,034,633
App. No.
14/632,982
Granted
Jul 31, 2018
Kind
B2
Abstract

Disclosed embodiments enable determining and monitoring the location of at least one particle in a subject's body, as well as the status of a local environment within the body where the at least one particle is located.

Claims (49)

1. An apparatus for monitoring an environment in a subject's body, the apparatus comprising:

at least one particle, introduced into the subject's body, the at least one particle including at least one spin torque nano-oscillator; and

at least one receiver located outside the subject's body,

wherein the receiver is sensitive to radiation emitted by the at least one spin torque nano-oscillator of the at least one particle.

2. The apparatus of claim 1 , further comprising at least one generator located outside the subject's body, the at least one generator generating a spatially-variant magnetic field.

3. The apparatus of claim 2 , where the radiation emission depends at least in part on a local environment within the subject's body in which the at least one particle is located.

4. The apparatus of claim 2 , wherein a local environment within the subject's body in which the at least one particle is located is affected at least in part by the at least one generator.

5. The apparatus of claim 1 , further comprising at least one generator that affects a local electromagnetic environment of the subject's body.

6. The apparatus of claim 5 , wherein the at least one particle is powered by the at least one generator.

7. The apparatus of claim 5 , wherein the at least one generator is a fuel cell.

8. The apparatus of claim 5 , wherein the at least one generator is a tribological generator.

9. The apparatus of claim 5 , wherein the at least one generator is a piezoelectric generator.

10. The apparatus of claim 5 , wherein the at least one generator is a variable capacitance generator.

11. The apparatus of claim 5 , where the local environment affected at least in part due to neuronal activity.

12. The apparatus of claim 1 , wherein the at least one particle contains magnetizable material.

13. The apparatus of claim 1 , further comprising at least one generator located outside of the subject's body, the at least one generator creating electromagnetic fields that are controlled to transport the at least one particle in the subject's body.

14. The apparatus of claim 1 , wherein a spatial distribution of the at least one particle is indicated by a response of the at least one particle to electromagnetic gradients created by at least one generator located outside the subject's body.

15. The apparatus of claim 1 , wherein a spatial distribution and state of the at least one particle is indicated by a response of the at least one particle to electromagnetic gradients created by at least one generator located outside the subject's body and by a response of the at least one particle to the local environment.

16. The apparatus of claim 1 , wherein the at least one particle influences a local environment in which the at least one particle is located as a result of a change in the local environment.

17. The apparatus of claim 1 , wherein the at least one particle is oriented preferentially as a result of coatings.

18. The apparatus of claim 1 , wherein current from a one or more nerves in electrical contact with the at least one particle is compressed to apply a shorter and stronger current to the spin torque nano-oscillator.

19. The apparatus of claim 1 , wherein assemblies of spin torque nano-oscillators fire synchronously to boost a signal received by the at least one receiver outside the body.

20. The apparatus of claim 1 , wherein a frequency of the signal emitted by the spin torque nano-oscillator is influenced by an electromagnetic field applied with an external generator, and a threshold for signal emission is influenced by local milieu of the spin torque nano-oscillator.

21. The apparatus of claim 20 , wherein the threshold for emission by the spin torque nano-oscillator is influenced by both the electromagnetic field applied with the external generator, and a local milieu of the spin torque nano-oscillator.

22. A method for imaging neural activity in a subject's body using at least one particle with a spin torque nano-oscillator that emits electromagnetic radiation, the method comprising:

transporting at least one particle into or within the subject's body;

applying electromagnetic gradients to the at least one particle by at least one generator located outside the subject's body,

wherein the electromagnetic radiation emitted by the spin torque nano-oscillator is sensitive to electromagnetic aspects of a local environment associated with neural activity and is sensitive to electromagnetic gradients applied by the one or more generators external to the body, and

detecting the electromagnetic radiation emitted and generating an image based on the detected radiation,

wherein a spatial distribution of the at least one particle is indicated by a response of the at least one particle to electromagnetic gradients created by at the least one generator located outside the subject's body.

23. The method of claim 22 , further comprising generating, using at least one generator located outside the subject's body, a spatially-variant magnetic field.

24. The method of claim 23 , where the radiation emission depends at least in part on a local environment within the subject's body in which the at least one particle is located.

25. The method of claim 23 , wherein a local environment within the subject's body in which the at least one particle is located is affected at least in part by the at least one generator.

26. The method of claim 22 , further comprising at least one generator that affects a local electromagnetic environment of the subject's body.

27. The method of claim 26 , wherein the at least one particle is powered by the at least one generator.

28. The method of claim 26 , wherein the at least one generator is a fuel cell.

29. The method of claim 26 , wherein the at least one generator is a tribological generator.

30. The method of claim 26 , wherein the at least one generator is a piezoelectric generator.

31. The method of claim 26 , wherein the at least one generator is a variable capacitance generator.

32. The method of claim 26 , where the local environment affected at least in part due to neuronal activity.

33. The method of claim 22 , wherein the at least one particle contains magnetizable material.

34. The method of claim 22 , further comprising creating electromagnetic fields using at least one generator located outside of the subject's body, the at least one generator creating electromagnetic fields that are controlled to transport the at least one particle in the subject's body.

35. The method of claim 22 , wherein a state of the at least one particle is indicated by a response of the at least one particle to electromagnetic gradients created by at least one generator located outside the subject's body and by a response of the at least one particle to the local environment.

36. The method of claim 22 , wherein the at least one particle influences a local environment in which the at least one particle is located as a result of a change in the local environment.

37. The method of claim 22 , wherein the at least one particle is oriented preferentially as a result of coatings.

38. The method of claim 22 , wherein current from a milieu in which the at least one particle is located is compressed to apply a shorter and stronger current to the spin torque nano-oscillator.

39. The method of claim 22 , wherein assemblies of spin torque nano-oscillators fire synchronously to boost a signal received by the at least one receiver outside the body.

40. The method of claim 22 , wherein a frequency of the signal emitted by the spin torque nano-oscillator is influenced by an electromagnetic field applied with the external generator, and a threshold for signal emission is influenced by a local milieu of the spin torque nano-oscillator.

41. The method of claim 40 , wherein the threshold for emission by the spin torque nano-oscillator is influenced by both the electromagnetic field applied with the external generator, and a local environment of the spin torque nano-oscillator.

Assignments (3)
CHANGE OF NAME Recorded Jun 21, 2018
From: WEINBERG, IRVING N.
To: WEINBERG MEDICAL PHYSICS INC.
Reel/Frame 046408/0786 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 7, 2015
From: WAKS, EDO; SHAPIRO, BENJAMIN
To: UNIVERSITY OF MARYLAND, COLLEGE PARK
Reel/Frame 035583/0152 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 11, 2015
From: WEINBERG, IRVING N.
To: WEINBERG MEDICAL PHYSICS LLC
Reel/Frame 035136/0829 →
Continuity (3)
Continuation In Part 14221777 · Mar 21, 2014
Provisional Application 61945615 · Feb 27, 2014
Related Publication 20150238110A1 · Aug 27, 2015