Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

Inventors: Brian Metcalf (South San Francisco, CA); Chihyuan Chuang (South San Francisco, CA)

Assignee: Global Blood Therapeutics, Inc.

A61K31/4985 A61K31/192 A61K31/235 A61K31/41 A61K31/416 A61K31/437 A61K31/445 A61K31/4406 A61K31/4439 A61K31/47 C07C65/30 C07C69/76 C07D211/62 C07D213/30 C07D213/80 C07D215/14 C07D231/56 C07D257/04 C07D401/04 C07D471/04 C07D487/04

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Quick Facts

Patent No.: US 10,034,879
App. No.: 15/852,406
Granted: Jul 31, 2018
Kind: B2

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Abstract

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

Claims (3)

1. A compound having the structure:

2. A solid dosage form comprising a compound having the structure:

and a pharmaceutically acceptable excipient.

Assignments (8)

RELEASE OF SECURITY INTEREST Recorded Oct 6, 2022

From: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT

To: GLOBAL BLOOD THERAPEUTICS, INC.

Reel/Frame 061620/0186 →

SECOND AMENDED AND RESTATED PATENT SECURITY AGREEMENT Recorded Dec 22, 2021

From: GLOBAL BLOOD THERAPEUTICS, INC.

To: BIOPHARMA CREDIT PLC